A Strategy for the Formal C-N Cross-Coupling of Tertiary Amines.
Angew Chem Int Ed Engl
; : e202411555, 2024 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-39219402
ABSTRACT
We report a strategy for the C-N cross-coupling of tertiary amines via the in situ generation and displacement of N-acyl ammonium species. Specifically, treatment of diverse tertiary amines with TFAA or choroformates in the presence of NaI leads to the efficient generation of alkyl iodides, which can be engaged directly in Ni-catalyzed cross-couplings. The protocol is applicable to acyclic and cyclic systems, including highly hindered variants. Applications to the late-stage modification of complex heterocycles are presented.
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article