Structural review of SARS-CoV-2 antiviral targets.
Structure
; 32(9): 1301-1321, 2024 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-39241763
ABSTRACT
The coronavirus disease 2019 (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents the most disastrous infectious disease pandemic of the past century. As a member of the Betacoronavirus genus, the SARS-CoV-2 genome encodes a total of 29 proteins. The spike protein, RNA-dependent RNA polymerase, and proteases play crucial roles in the virus replication process and are promising targets for drug development. In recent years, structural studies of these viral proteins and of their complexes with antibodies and inhibitors have provided valuable insights into their functions and laid a solid foundation for drug development. In this review, we summarize the structural features of these proteins and discuss recent progress in research regarding therapeutic development, highlighting mechanistically representative molecules and those that have already been approved or are under clinical investigation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
SARS-CoV-2
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article