A solution NMR methodology enabling the elucidation of small molecule phospholipid membrane adhesion and passive permeation parameters.
Chem Commun (Camb)
; 60(79): 11160-11163, 2024 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-39291600
ABSTRACT
Quantifying small molecule uptake across a biological membrane of a target cell is crucial for the development of efficacious and selective drugs. However, current methods to obtaining such data are not trivial. Herein, we present an accessible, higher-throughput (20 minutes), 1H NMR spectroscopy assay, which enables the quantification of small molecule phospholipid passive membrane permeation and membrane adhesion parameters.
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MEDLINE
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Fosfolipídeos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article