Pentose phosphate pathway inhibition in blood cells during anticonceptive hormone therapy.
Pharmacology
; 11(2): 108-16, 1974.
Article
em En
| MEDLINE
| ID: mdl-4829290
ABSTRACT
PIP The transketolase activity (TKA) of the white and red blood cells of oral contraceptive users was studied in an unselected sample population. Compared with healthy controls of corresponding age, the white cell TKA in the oral contraceptive groups was lowered in about 30%. The red cell TKA was lowered in about 15% of the subjects studied. The most pronounced TKA inactivation was observed in the group taking pills that contained mestranol and megestrol acetate. The glucose tolerance tests were normal. Discontinuing the hormones normalized the white cell TKA.^ieng
Palavras-chave
Biology; Carbohydrate Metabolic Effects; Chlormadinone Acetate; Clinical Research; Comparative Studies; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Contraceptive Methods--side effects; Enzymatic Effects; Enzymes And Enzyme Inhibitors; Ethinyl Estradiol; Family Planning; Glucose Metabolism Effects; Hematological Effects; Hemic System; Levonorgestrel; Lynestrenol; Megestrol Acetate; Mestranol; Metabolic Effects; Norethindrone; Norethindrone Acetate; Norgestrel; Oral Contraceptives, Combined--side effects; Oral Contraceptives--side effects; Physiology; Progestins, Low-dose--side effects; Research Methodology; Studies
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Base de dados:
MEDLINE
Assunto principal:
Pentoses
/
Transcetolase
/
Anticoncepcionais Orais
/
Eritrócitos
/
Leucócitos
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article