Digitonin effects on photoreceptor adenylate cyclase.
Science
; 175(4028): 1363-4, 1972 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-5059564
ABSTRACT
Adenylate cyclase is described in a number of photoreceptor membranes. Vertebrate rod outer segments contain light-regulated cyclase, and light regulation is abolished by digitonin. Disruption of microvilli in cone and rhabdomphotoreceptors is also associated with loss of light regulation and retention of full enzymic activity. The data suggest that inhibitory constraint provides regulation in cyclase systems and that disruption of membrane structure uncouples catalytic and regulatory elements.
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Base de dados:
MEDLINE
Assunto principal:
Células Fotorreceptoras
/
Adenilil Ciclases
/
Glicosídeos Digitálicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1972
Tipo de documento:
Article