Secretory component as the receptor for polymeric IgA on rat hepatocytes.
J Exp Med
; 150(6): 1577-81, 1979 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-512591
ABSTRACT
Rat hepatocytes in short-term monolayer cultures bound radiolabeled polymeric rat IgA but not IgG. The binding of 125I-IgA was inhibited equally well by unlabeled polymeric IgA and by antiserum to rat secretory component (SC). The antibody to SC, after specific purification and radiolabeling, was bound to hepatocytes as effectively as the IgA. These results indicate that SC acts as the receptor for polymeric IgA on rat hepatocytes as it does on human gut epithelia, and that the transport of IgA from blood to bile in rats across the liver is analogous to that of IgA across human enterocytes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
/
Componente Secretório
/
Fragmentos de Imunoglobulinas
/
Receptores Imunológicos
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article