Adenylate cyclase activation shifts the phase of a circadian pacemaker.
Science
; 220(4592): 82-4, 1983 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-6298939
ABSTRACT
Forskolin, a highly specific activator of adenylate cyclase, produced both delay and advance phase shifts of the circadian rhythm recorded from the isolated eye of the marine mollusk Aplysia. The phase dependence of the response to forskolin was identical to that with serotonin, which also stimulates adenylate cyclase in the eye. The ability of agents to activate adenylate cyclase in homogenates was correlated with their ability to shift the phase of the circadian oscillator. These results along with earlier findings show that adenosine 3',5'-monophosphate mediates the effect of serotonin on the rhythm and regulates the phase of the circadian pacemaker in the eye of Aplysia.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Adenilil Ciclases
/
Ritmo Circadiano
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article