Coincidence of down-regulation and desensitization in pituitary gonadotrophs stimulated by gonadotropin releasing hormone.
Life Sci
; 32(6): 663-9, 1983 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-6300603
ABSTRACT
The dynamics of gonadotropin releasing hormone (GnRH) induced luteinizing hormone (LH) release was studied in vitro by superfusion of cultured pituitary cells. Continuous exposure of the cells to GnRH resulted in desensitization of the gonadotroph responsiveness to further stimulation by the hormone. The refractory state was achieved within 4 hr of hormone introduction (10(-7) M) and was accompanied by down-regulation of GnRH receptors (50%) assayed by equilibration with [125I]iodo-[D-Ala6]des-Gly10-GnRH N-ethylamide. The data indicate that GnRH can regulate the number of its own receptors, and that desensitization is accompanied by down-regulation.
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Base de dados:
MEDLINE
Assunto principal:
Hipófise
/
Hormônio Luteinizante
/
Hormônios Liberadores de Hormônios Hipofisários
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article