The disordering effect of hyoscyamine drugs on phospholipid membranes.
Biochim Biophys Acta
; 736(2): 220-5, 1983 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-6317032
ABSTRACT
The effect of hyoscyamine drugs on the fluidity of dipalmitoylphosphatidylcholine liposomes has been studied by differential scanning calorimetry (DSC), electron spin resonance spectroscopy (ESR), fluorescence polarization and freeze-fracture electron microscopic techniques. DSC results indicate that anisodamine, anisodine, atropine and scopolamine all increase the fluidity of dipalmitoylphosphatidylcholine liposomes but with different degrees of efficiency. The increasing of fluidity of dipalmitoylphosphatidylcholine liposomes by hyoscyamine drugs is in a dose-dependent way. Increase of the fluidity of phosphatidylcholine liposomes by anisodamine was also shown by the other three methods. The possible mechanism of hyoscyamine-membrane interaction is discussed.
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Base de dados:
MEDLINE
Assunto principal:
Atropina
/
Derivados da Atropina
/
Surfactantes Pulmonares
/
Lipossomos
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article