Antihypertensive action of bendroflumethiazide: increased prostacyclin production?
Clin Pharmacol Ther
; 28(6): 751-8, 1980 Dec.
Article
em En
| MEDLINE
| ID: mdl-7002430
ABSTRACT
A within-patient randomized, double-blind, crossover study was performed to investigate mechanisms of action of bendroflumethiazide in mild essential hypertension. Significant reductions in lying, standing, and postexercise blood pressure were seen after both 3 days and 10 wk treatment with bendroflumethiazide 10 mg daily. Plasma levels of 6-oxo-PGF1 alpha, the chemical hydrolysis product of prostacyclin, were increased by both 3 days and 10 wk therapy with bendroflumethiazide. This raises the possibility that thiazides may reduce peripheral resistance by increasing prostacyclin biosynthesis.
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Base de dados:
MEDLINE
Assunto principal:
Bendroflumetiazida
/
Prostaglandinas
/
Epoprostenol
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article