Utilization by the isolated perfused rat liver of N-acetyl-D-[1-14C]galactosamine and N-[3H]acetyl-D-galactosamine for the biosynthesis of glycoproteins.
Biochem J
; 174(2): 421-6, 1978 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-708394
ABSTRACT
The isolated perfused rat liver system has been used to monitor the utilization of N-[3H]acetyl-D-galactosamine and N-acetyl-D-[1-14C]galactosamine for the biosynthesis of radiolabelled glycoproteins, which are subsequently secreted into the plasma. Both radiolabels appear in a number of different glycoproteins, predominantly as sialic acid and N-acetylglucosamine. The ratio of labelled sialic acid to labelled N-acetylglucosamine varies for different glycoproteins, but the bulk of N-acetyl-D-galactosamine is incorporated without deacetylation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilgalactosamina
/
Glicoproteínas
/
Galactosamina
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article