T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis.
Science
; 263(5150): 1139-43, 1994 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-7509084
ABSTRACT
Encounters with antigen can stimulate T cells to become activated and proliferate, become nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to interleukin-2-stimulated cell cycling and T cell receptor reengagement at high antigen doses. This feedback regulatory mechanism attenuates the immune response by deleting a portion of newly dividing, antigen-reactive T cells. This mechanism deleted autoreactive T cells and abrogated the clinical and pathological signs of autoimmune encephalomyelitis in mice after repetitive administration of myelin basic protein.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Linfócitos T CD4-Positivos
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Encefalomielite Autoimune Experimental
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Tolerância Imunológica
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Antígenos
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article