PBDX is the XG blood group gene.
Nat Genet
; 8(3): 285-90, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-7533029
ABSTRACT
We have identified the Xga antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as PBDX. In indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a-) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xga. Therefore, by its identity with PBDX, Xga is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of MIC2 which is tightly linked to XG. PBDX is renamed here XG.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Grupos Sanguíneos
/
Antígenos CD
/
Moléculas de Adesão Celular
/
Genes
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article