T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.
Science
; 261(5123): 918-21, 1993 Aug 13.
Article
em En
| MEDLINE
| ID: mdl-7688481
ABSTRACT
The zeta subunit of the T cell antigen receptor complex is required for targeting nascent receptor complexes to the cell surface and for receptor-mediated signal transduction. To examine the significance of the zeta subunit in T cell development, mice deficient for zeta expression were generated by gene targeting. These zeta-/- mice had few CD4+CD8+ thymocytes, and the generation of CD4+ and CD8+ single positive T cells was impaired but not completely abrogated. Peripheral T cells were present but were unusual in that they expressed small amounts of CD5 and few T cell receptors. Thus, zeta chain expression influences thymocyte differentiation but is not absolutely required for the generation of single positive T cells.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Subpopulações de Linfócitos T
/
Proteínas de Membrana
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article