Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP).
Cancer Lett
; 88(1): 81-6, 1995 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-7850777
ABSTRACT
cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.
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Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Cisplatino
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article