Familial primary hyperparathyroidism complicated with Wilms' tumor.
Intern Med
; 33(2): 123-6, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-7912571
ABSTRACT
We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-year-old woman who had a parathyroid adenoma. Her older sister had a parathyroid adenoma with cementifying jaw fibroma and her younger sister died of parathyroid adenocarcinoma with pulmonary metastasis at the age of 38. We have not yet obtained evidence for other endocrine disorders suggesting multiple endocrine neoplasia (MEN) in this pedigree. The proband is complicated with Wilms' tumor. It is now widely accepted that respective predisposed genes of MEN type 1 and Wilms' tumor, and PTH gene are located on chromosome 11. The manifestation observed in this case may be related to mutational abnormalities on chromosome 11.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias das Paratireoides
/
Síndromes Neoplásicas Hereditárias
/
Adenocarcinoma
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Adenoma
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Segunda Neoplasia Primária
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Tumor de Wilms
/
Hiperparatireoidismo
/
Neoplasias Renais
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article