Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster.
Science
; 266(5191): 1697-702, 1994 Dec 09.
Article
em En
| MEDLINE
| ID: mdl-7992053
ABSTRACT
The association between quantitative genetic variation in bristle number and molecular variation at a candidate neurogenic locus, scabrous, was examined in Drosophila melanogaster. Approximately 32 percent of the genetic variation in abdominal bristle number (21 percent for sternopleural bristle number) among 47 second chromosomes from a natural population was correlated with DNA sequence polymorphisms at this locus. Several polymorphic sites associated with large phenotypic effects occurred at intermediate frequency. Quantitative genetic variation in natural populations caused by alleles that have large effects at a few loci and that segregate at intermediate frequencies conflicts with the classical infinitesimal model of the genetic basis of quantitative variation.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Variação Genética
/
Glicoproteínas
/
Proteínas
/
Genes de Insetos
/
Proteínas de Drosophila
/
Drosophila melanogaster
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article