Pharmacokinetics and tissue distribution of iomeprol in animals.
Eur J Radiol
; 18 Suppl 1: S13-20, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-8020515
ABSTRACT
The pharmacokinetics of iomeprol, a new triiodinated nonionic radiographic contrast agent, has been studied in rats, rabbits and dogs. Following intravenous administration, iomeprol did not bind measurably to plasma proteins and was rapidly excreted in unchanged form, mostly through the kidneys. The compound was rapidly distributed to the plasma and thence to the extracellular spaces. Iomeprol did not accumulate in specific organs or tissues except for those involved in its elimination, i.e. the kidneys and the liver. However, 24 h after administration, less than 1% of the injected dose remained in the tissues. The overall profile was very similar to the published profiles of other radiographic contrast agents used in uroangiography.
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Base de dados:
MEDLINE
Assunto principal:
Iopamidol
/
Meios de Contraste
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article