Transplantation of a hepatitis B surface antigen-positive donor liver into a hepatitis B virus-negative recipient.
Transplantation
; 58(1): 114-6, 1994 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-8036699
ABSTRACT
A critically ill, HBV seronegative girl who received a liver from a HBsAg+ donor is described. Despite HBV Ig prophylaxis, she was seropositive for HBsAg shortly after transplantation. Although the postoperative period was complicated, HBV-related problems were not encountered. Liver dysfunction was noted 7 months after transplantation. At that time, she became anti-HBc IgM-positive, with liver histologic findings suggestive of chronic active hepatitis B. The liver function normalized after a reduction of immunosuppressive therapy and introduction of ciprofloxacin. The patient had low level HBV replication during the entire follow-up period (HBV DNA-positive by PCR only) and sequencing of the virus on 4 occasions revealed only wild-type HBV. She subsequently lost serum HBsAg and HBV DNA (even by PCR) and has remained well 2 years after transplantation.
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Base de dados:
MEDLINE
Assunto principal:
Doadores de Tecidos
/
Transplante de Fígado
/
Hepatite B
/
Antígenos de Superfície da Hepatite B
Limite:
Child
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article