Molecular cytogenetic characterization of marker chromosomes found at prenatal diagnosis.
Prenat Diagn
; 13(5): 385-94, 1993 May.
Article
em En
| MEDLINE
| ID: mdl-8341637
ABSTRACT
The nature and origin of two de novo small marker chromosomes found at prenatal diagnosis were determined by fluorescence in situ hybridization using chromosome centromere-specific probes and chromosome-specific plasmid libraries. One marker was found in a mosaic state and was shown to be an i(18p). The second marker was characterized as an inv dup(22). We conclude that molecular cytogenetic analysis contributes to the identification of marker chromosomes and therefore facilitates genetic counselling and decision-making for the parents.
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Base de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
/
Marcadores Genéticos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article