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Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutrophil alkaline phosphatase scores.
Fujimura, T; Ohyashiki, K; Ohyashiki, J H; Kawakubo, K; Iwabuchi, A; Kodama, A; Toyama, K.
Afiliação
  • Fujimura T; First Department of Internal Medicine, Tokyo Medical College, Japan.
Cancer Genet Cytogenet ; 68(2): 143-6, 1993 Jul 15.
Article em En | MEDLINE | ID: mdl-8353806
ABSTRACT
We report two additional patients with acute myeloid leukemia (AML) and a translocation between chromosomes 7 and 11 t(7;11)(p15;p15). One patient was diagnosed as having AML-M2 and the other as AML with myelofibrosis. Both patients had low-level neutrophil alkaline phosphatase (NAP) scores. In the literature, only 15 AML patients with t(7;11)(p15;p15) have been reported; nine of them had an AML-M2 morphology, and all had a decreased NAP score. Moreover, mean survival of the reported AML patients with t(7;11)(p15;p15) was 15 months, although 85% of them obtained complete remission, indicating that this type of leukemia frequently tends to relapse. These findings indicate a strong association between the chromosome abnormality and hematologic manifestations of this disease.
Assuntos
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Base de dados: MEDLINE Assunto principal: Translocação Genética / Cromossomos Humanos Par 7 / Cromossomos Humanos Par 11 / Leucemia Mieloide Aguda / Leucemia Mieloide Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1993 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Translocação Genética / Cromossomos Humanos Par 7 / Cromossomos Humanos Par 11 / Leucemia Mieloide Aguda / Leucemia Mieloide Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1993 Tipo de documento: Article