A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells.
Proc Natl Acad Sci U S A
; 93(5): 1820-4, 1996 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-8700842
ABSTRACT
Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Linfócitos T
/
Complexo Principal de Histocompatibilidade
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article