Androgenic control of 1-alkyl-2,3-diacylglycerol in the harderian gland of the golden hamster, Mesocricetus auratus.
J Biochem
; 119(4): 799-804, 1996 Apr.
Article
em En
| MEDLINE
| ID: mdl-8743584
ABSTRACT
Harderian glands of golden hamsters produce a copious lipid secretion, most of which is in the form of 1-alkyl-2,3-diacylglycerol (ADG). Sexual differences are seen in the composition of golden hamster ADG and in the morphology of secretory lipid droplet. ADGs from females contained abundant iso- and anteiso-branched chain alkyl groups and fatty acids [Seyama, Y., Otsuka, H., Ohashi, K., Vivien-Roels, B., and Pevet, P. (1995) J. Biochem. 117, 661-670]. Female hamsters were either untreated or given subcutaneous testosterone pellets. Treatment of females with testosterone led to the disappearance of such branched chain alkyl groups and fatty acids. Intact males had ADGs with entirely saturated straight chain alkyl groups and fatty acids. Castration led to the appearance of iso- and anteiso-branched chain alkyl groups and fatty acids. These observations suggested that the production of branched chain fatty acids in the Harderian gland of golden hamster is inhibited by testosterone at the step of isovaleryl-CoA dehydrogenase and 2-methyl branched-chain acyl-CoA dehydrogenase
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Éteres de Glicerila
/
Diglicerídeos
/
Glândula de Harder
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article