Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-beta gene families.
J Cell Biol
; 139(1): 145-56, 1997 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-9314535
ABSTRACT
We have examined whether the development of embryonic muscle fiber type is regulated by competing influences between Hedgehog and TGF-beta signals, as previously shown for development of neuronal cell identity in the neural tube. We found that ectopic expression of Hedgehogs or inhibition of protein kinase A in zebrafish embryos induces slow muscle precursors throughout the somite but muscle pioneer cells only in the middle of the somite. Ectopic expression in the notochord of Dorsalin-1, a member of the TGF-beta superfamily, inhibits the formation of muscle pioneer cells, demonstrating that TGF-beta signals can antagonize the induction of muscle pioneer cells by Hedgehog. We propose that a Hedgehog signal first induces the formation of slow muscle precursor cells, and subsequent Hedgehog and TGF-beta signals exert competing positive and negative influences on the development of muscle pioneer cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação para Baixo
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Regulação para Cima
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Fator de Crescimento Transformador beta
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Fibras Musculares Esqueléticas
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Regulação da Expressão Gênica no Desenvolvimento
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Proteínas de Insetos
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Proteínas de Peixe-Zebra
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Proteínas de Drosophila
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article