Experimental antitumour activity of S 16020-2 in a panel of human tumours.
Eur J Cancer
; 33(11): 1881-7, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9470851
ABSTRACT
The antitumour activity of S 16020-2, a new topoisomerase II inhibitor, was evaluated in comparison with doxorubicin against 13 human tumours, including colon (HT-29, Colo320DM), breast (MCF7, MDAMB-231), ovary (SK-OV-3, A2780, NIHOVCAR-3), non-small cell lung (NCI-H460, A549, Calu-6, NCI-H125) and small-cell lung (NCI-H69, SCLC6) cancers. S 16020-2 was administered weekly intravenous within a dose range of 20-90 mg/kg for 3 weeks. Antitumour responses were obtained in all the tumour types tested except in the two colon cancers. S 16020-2 produced significant growth delays in nine tumour models and induced regressions of all A549 lung tumours. The antitumour activity of S 16020-2 was superior to that of doxorubicin against the NCI-H460, A549, NCI-H69, SCLC6 and NIHOVCAR-3 xenografts. These results demonstrate the broad spectrum of antitumour activity of S 16020-2 in a large panel of in vivo experimental models and confirm its interest as a potential agent in the treatment of malignant disease.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
/
Elipticinas
/
Antibióticos Antineoplásicos
/
Antineoplásicos Fitogênicos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article