Protective effect of passive immunization against TNF-alpha in mice infected with Sendai virus.
Exp Anim
; 47(1): 49-54, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9498113
ABSTRACT
TNF-alpha has been reported to be induced in mice infected with Sendai virus. We evaluated the role of TNF-alpha in the virus infection. TNF-alpha was induced locally in proportion to virus titers in the lung. The activity was correlated with suppression of body weight gain. Passive immunization against TNF-alpha improved body weight gain and ameliorated pneumonic lesions in infected mice, and prevented them from lethal infection, but lung virus induced emaciation, pneumonic lesions and death were mediated by TNF-alpha.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Respirovirus
/
Imunização Passiva
/
Fator de Necrose Tumoral alfa
/
Respirovirus
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article