Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition.
J Antibiot (Tokyo)
; 51(1): 41-9, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9531986
ABSTRACT
A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Policíclicos
/
Inibidores da Síntese de Proteínas
/
Fungos Mitospóricos
/
Antifúngicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article