Distinct mechanism for antidepressant activity by blockade of central substance P receptors.
Science
; 281(5383): 1640-5, 1998 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-9733503
ABSTRACT
The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P antagonists might have psychotherapeutic properties. Like clinically used antidepressant and anxiolytic drugs, substance P antagonists suppressed isolation-induced vocalizations in guinea pigs. In a placebo-controlled trial in patients with moderate to severe major depression, robust antidepressant effects of the substance P antagonist MK-869 were consistently observed. In preclinical studies, substance P antagonists did not interact with monoamine systems in the manner seen with established antidepressant drugs. These findings suggest that substance P may play an important role in psychiatric disorders.
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Base de dados:
MEDLINE
Assunto principal:
Substância P
/
Morfolinas
/
Antidepressivos de Segunda Geração
/
Transtorno Depressivo
/
Antagonistas dos Receptores de Neurocinina-1
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article