Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis.
J Leukoc Biol
; 64(4): 441-50, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9766624
ABSTRACT
Malignant histiocytosis sarcoma virus (MHSV) arose as a recombinant of c-Harvey-ras murine sarcoma virus (Ha-MuSV) and Friend mink cell focus-forming virus (F-MCFV). It is a defective acute transforming retrovirus that, along with Friend murine leukemia helper virus (F-MuLV), induces malignant histiocytosis (MH) in susceptible adult mice. We have assessed the in vivo susceptibility to MHSV in inbred homozygous, F1 hybrid, congenic, and recombinant inbred (RI) mice. We have shown that (1) in vivo resistance to MHSV is multigenic, regulated by MHC and non-MHC genes in a different fashion than with F-MCFV, F-MuLV, or Ha-MuSV; (2) using BXD RI mice, the resistance phenotype is linked with 95.8% probability to two linked loci, Pmv-9 and Iapls3-14, on chromosome 13 (homologous to the area of human chromosome 5 for which a chromosomal break point at position 5q35 is associated with human MH); and (3) CD4+ T cells are critical for MHSV resistance.
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Base de dados:
MEDLINE
Assunto principal:
Mapeamento Cromossômico
/
Infecções por Retroviridae
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Sarcoma Histiocítico
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Complexo Principal de Histocompatibilidade
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article