Lectin-mediated bioadhesion: binding characteristics of plant lectins on the enterocyte-like cell lines Caco-2, HT-29 and HCT-8.
J Control Release
; 55(2-3): 131-42, 1998 Nov 13.
Article
em En
| MEDLINE
| ID: mdl-9795030
ABSTRACT
In order to take advantage of the biorecognition between lectins and specific carbohydrates for targeted drug delivery, fluorescein-labelled lectins of different carbohydrate specificities were screened for binding to human colorectal carcinoma cell lines by flow cytometry and confocal microscopy. The lectin-binding rate increased as follows Dolichos biflorus agglutinin, DBA<peanut agglutinin, PNA<Lens culinaris agglutinin, LCA<Solanum tuberosum lectin, STL<Ulex europaeus isoagglutinin I, UEA-I<wheat germ agglutinin, WGA (Caco-2); PNA
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Base de dados:
MEDLINE
Assunto principal:
Adesão Celular
/
Mucosa Intestinal
/
Lectinas
Limite:
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article