الملخص
Pithecellobium dulce, an evergreen medium-sized, spiny tree, each part of the plant has vast nutritional values; stuffedwith essential vitamins, amino acids, and minerals. The fruits of P. dulce were widely used in Ayurvedic medicinesand home remedies. The plant has also been a rich source of biologically active compounds such as tannin, olein,and glycosides. Totally 38 active phytocompounds like quercetin, kaempferol, and dulcitol were identified from thevarious parts of the plant. Notably, this plant has catechol type of tannins in the bark. There are polyphenol classesof phytocompounds which have found to hold potent antivenom activity. Their fruits are a rich source of phenols,flavonoids, and saponins reported for their efficacy to treat diabetes, oxidative stress, and gastrointestinal disorders.The plant leaf and seed have an antibacterial, antifungal, and adulticidal activities. Thus, the present review describeson exploiting the medicinal properties of P. dulce and its biomedicinal applications in therapeutic development.
الملخص
ABSTRACT Tuberculosis is leading cause of death among the global bacterial infections. The main causative for tuberculosis is Mycobacterium tuberculosis, which will survive in its host human being for decades in latent or chronic levels. In addition, the late multidrug resistance at a disturbing rate accompanies the appearance of tuberculosis. The quick spread of resistance to initial stage treatment medications has redirected the focus of the medical community in the creation of an array of new drug against Mycobacterium tuberculosis. The InhA protein is a component of Fatty acid synthetase (FAS) II and exhibits an NADH reliant enoyl-ACP reductase activity. InhA is a vital enzyme of M.tuberculosis in control of cell wall synthesis, which can turn out to be a great focus for the synthesis of anti-tubercular treatment. Inspired from the offering biological actions of phytoconstituents from Allium sativum, the current research concentrates on looking at novel lead compounds from the plant. Molecular docking studies were carried out employing specific phytoconstituents from A.sativum with the protein InhA target. Ajoene shows much more encouragingresults with a Mol Dock rating of 80.6047Kcal/mol, as opposed to the typical initial line drug isoniazid (Moldock score: -58.7028 Kcal/mol). Molecular docking prediction indicate that Ajoene could be formulated into a possible treatment drug for Mycobacterium tuberculosis.