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BACKGROUND@#Heatstroke is one of the most serious heat-related illnesses. However, establishing public policies to prevent heatstroke remains a challenge. This study aimed to investigate the most relevant climate elements and their warning criteria to prevent outdoor heatstroke (OHS).@*METHODS@#We investigated heatstroke patients from five major hospitals in Daegu metropolitan city, Korea, from June 1 to August 31, 2011 to 2016. We also collected the corresponding regional climate data from Korea Meteorological Administration. We analyzed the relationship between the climate elements and OHS occurrence by logistic regression.@*RESULTS@#Of 70 patients who had heatstroke, 45 (64.3%) experienced it while outdoors. Considering all climate elements, only mean heat index (MHI) was related with OHS occurrence (p=0.019). Therefore, the higher the MHI, the higher the risk for OHS (adjusted odds ratio, 1.824; 95% confidence interval, 1.102–3.017). The most suitable cutoff point for MHI by Youden’s index was 30.0°C (sensitivity, 77.4%; specificity, 73.7%).@*CONCLUSION@#Among the climate elements, MHI was significantly associated with OHS occurrence. The optimal MHI cutoff point for OHS prevention was 30.0°C.
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BACKGROUND: Heatstroke is one of the most serious heat-related illnesses. However, establishing public policies to prevent heatstroke remains a challenge. This study aimed to investigate the most relevant climate elements and their warning criteria to prevent outdoor heatstroke (OHS).METHODS: We investigated heatstroke patients from five major hospitals in Daegu metropolitan city, Korea, from June 1 to August 31, 2011 to 2016. We also collected the corresponding regional climate data from Korea Meteorological Administration. We analyzed the relationship between the climate elements and OHS occurrence by logistic regression.RESULTS: Of 70 patients who had heatstroke, 45 (64.3%) experienced it while outdoors. Considering all climate elements, only mean heat index (MHI) was related with OHS occurrence (p=0.019). Therefore, the higher the MHI, the higher the risk for OHS (adjusted odds ratio, 1.824; 95% confidence interval, 1.102–3.017). The most suitable cutoff point for MHI by Youden’s index was 30.0°C (sensitivity, 77.4%; specificity, 73.7%).CONCLUSION: Among the climate elements, MHI was significantly associated with OHS occurrence. The optimal MHI cutoff point for OHS prevention was 30.0°C.
الموضوعات
Humans , Climate , Heat Stroke , Hot Temperature , Incidence , Korea , Logistic Models , Meteorology , Odds Ratio , Public Policy , Sensitivity and Specificityالملخص
OBJECTIVE: Heat stroke is a serious heat-related illness characterized by elevated core body temperature and an impaired central nervous system. Heat stroke can also cause various complications and lead to irremediable results. However, early prediction of its outcome remains difficult. In this study, we analyzed clinical features and laboratory findings according to the outcome of heat stroke patients and tried to identify factors that predict their prognosis in the acute stage. METHODS: In this retrospective observational study, we enrolled 40 heat stroke patients who arrived at five emergency departments in Daegu within three hours from the time at which heat stroke occurred every June 1 to August 31 from 2011 to 2016. In addition, we compared the clinical features and laboratory findings according to the outcome. RESULTS: The mean ages were 72.0 (53.0–76.0) in the good outcome group (GOG) and 57.0 (39.5–84.8) in the poor outcome group (POG). In addition, there were 23 (71.9%) and five (62.5%) men in the GOG and the POG, respectively. Among clinical characteristics, initial neurological status and endotracheal intubation differed significantly by prognosis (P=0.019 and P=0.001, respectively). Among laboratory findings, arterial bicarbonate ion level, platelet count, and aspartate aminotransferase level were differed significantly by prognosis (P=0.003, P=0.005, and P=0.009, respectively). CONCLUSION: An initial decline in consciousness, conducting endotracheal intubation, decreased arterial bicarbonate ion level or platelet count, as well as increased aspartate aminotransferase levels were poor prognosis factors of heat stroke patients in the acute stage. Emergency physicians should be careful when managing these patients.
الموضوعات
Humans , Male , Aspartate Aminotransferases , Bicarbonates , Body Temperature , Central Nervous System , Climate Change , Consciousness , Emergencies , Emergency Service, Hospital , Heat Stroke , Hot Temperature , Intubation, Intratracheal , Observational Study , Platelet Count , Prognosis , Retrospective Studiesالملخص
Splenic artery aneurysm is the third most common type of intra-abdominal aneurysm, with a prevalence rate of 0.01% to 10.4% in the general population. Splenic artery aneurysm is usually asymptomatic and is typically detected by chance and does not require surgical management; however, if rupture occurs, although rare, the patient's situation can become critical. We report our experience with a man who presented with left flank and left shoulder pain. His symptoms were caused by multiple hematomas confined to the spleen, but 2 days after admission, he developed delayed hemoperitoneum and required surgical management. We believe that his condition was due to delayed intraperitoneal bleeding called the double-rupture phenomenon; emergency physicians must consider this phenomenon when taking care of splenic artery aneurysm patients.
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Humans , Aneurysm , Emergencies , Hematoma , Hemoperitoneum , Hemorrhage , Prevalence , Rupture , Shoulder Pain , Spleen , Splenic Arteryالملخص
PURPOSE: This study was performed to investigate the preventable death rate (PDR) in Daegu, South Korea, and to assess both its affecting- and preventable-factors to improve the treatment of regional trauma patients. METHODS: All cases of traumatic death that occurred between January 2012 and December 2012 in five hospitals in Daegu were analyzed retrospectively by a panel review. Cases were classified into preventable (P) and non-preventable deaths (NP). We determined the affecting factors of trauma deaths and preventable factors during trauma care. RESULTS: The PDR was 25.2%. Significant differences by mode of arrival, day of injury, cause of death, and time of emergency department (ED) arrival were observed between P and NP groups. According to the logistic regression analysis, preventability was associated with patients transferred from other hospitals, ED arrival at night and dawn, and non-head injuries. A total of 145 preventable factors were discovered in 59 preventable trauma deaths. When we categorized by location, the ED was the most common, with 71 cases, followed by 57 prehospital preventable factors. When we classified the preventable factors by process, 76.8% were process-related and 23.4% were structure-related. CONCLUSION: Our study is valuable to build an adequate trauma system in Daegu as it provides the baseline quality control data. Efforts to mediate the preventable factors were revealed in this study, and continuous reviews to calculate and track the PDR are needed to evaluate the local trauma system and establish a system specific to Daegu.
الموضوعات
Humans , Cause of Death , Emergency Service, Hospital , Korea , Logistic Models , Mortality , Outcome and Process Assessment, Health Care , Quality Control , Retrospective Studiesالملخص
Subcutaneous emphysema and pneumomediastinum are commonly derived from trauma or injury of respiratory or gastrointestinal tracts, but occasionally the origin of air was not determined at evaluation. We report on a case of severe subcutaneous emphysema detected using simple X-ray films in the emergency department, which extended to almost all of the bodies, with a review of the literature.
الموضوعات
Edema , Emergency Service, Hospital , Gastrointestinal Tract , Mediastinal Emphysema , Subcutaneous Emphysema , X-Ray Filmالملخص
PURPOSE: Daegu, Korea was severely affected by pandemic and post-pandemic H1N1 infection during August 2009 to March 2012. The aim of this study was to analyze various clinical characteristics of patients who visited the emergency department with H1N1 infection during the first three years, and to compare the results for each year. We then performed an evaluation of the differences. METHODS: The medical records of patients who visited our emergency department and conformed to H1N1 virus infection by conventional rRT-PCR during the pandemic wave from August 2009 to March 2010(wave 1) and post-pandemic waves from August 2010 to March 2011(wave 2) and from August 2011 to March 2012(wave 3) were reviewed. A total of 986 patients (wave 1; 840, wave 2; 144, wave 3; 2) were included in this study. We analyzed the clinical characteristics, proportions of pneumonia, admission rate, relationships with underlying medical conditions, and requirement for mechanical ventilation of the infected patients, and then performed a statistical evaluation of the differences between wave 1 and wave 2 that was severely affected. RESULTS: During wave 1,840 patients, during wave 2, 144 patients, and during wave 3, two patients were diagnosed as novel influenza. Age 18-39 showed a significantly higher rate(78.7%) in the wave 1 patients group. Main clinical symptoms were cough and febrile sense in both waves. Patients with underlying medical conditions in wave 2(97 cases, 67.4%) showed a higher rate than those of wave 1(101 cases, 12.0%). Chronic obstructive pulmonary disorder was the most closely related underlying disorder in wave 2(18.8%). Patients requiring admission(37.5%) and ventilatory care(6.9%) due to severe pneumonic symptoms showed a significantly higher rate in wave 2. Only two young patients were diagnosed as novel influenza. Both complained of mild fever and cough, which recovered spontaneously. CONCLUSION: Most cases of influenza A (H1N1) infection were uncomplicated, characterized by influenza-like symptoms and spontaneous recovery. The number of patients showed a marked decreased year by year, however, the severity of clinical presentations increased in wave 2. Young adults who did not have cross-reactive antibodies to novel influenza A (H1N1) from previous infection or immunization were dominant in wave 1. Older patients with underlying medical conditions were more likely to admitted and present fatal progress in wave 1 and wave 2. Because influenza viruses are unpredictable, continued national preparedness, flexible response, and careful monitoring are essential.
الموضوعات
Humans , Young Adult , Antibodies , Cough , Emergencies , Emergency Service, Hospital , Epidemiology , Fever , Immunization , Influenza A Virus, H1N1 Subtype , Influenza, Human , Korea , Medical Records , Observational Study , Orthomyxoviridae , Pandemics , Pneumonia , Respiration, Artificialالملخص
PURPOSE: Daegu, Korea was severely affected by pandemic and post-pandemic H1N1 infection during August 2009 to March 2012. The aim of this study was to analyze various clinical characteristics of patients who visited the emergency department with H1N1 infection during the first three years, and to compare the results for each year. We then performed an evaluation of the differences. METHODS: The medical records of patients who visited our emergency department and conformed to H1N1 virus infection by conventional rRT-PCR during the pandemic wave from August 2009 to March 2010(wave 1) and post-pandemic waves from August 2010 to March 2011(wave 2) and from August 2011 to March 2012(wave 3) were reviewed. A total of 986 patients (wave 1; 840, wave 2; 144, wave 3; 2) were included in this study. We analyzed the clinical characteristics, proportions of pneumonia, admission rate, relationships with underlying medical conditions, and requirement for mechanical ventilation of the infected patients, and then performed a statistical evaluation of the differences between wave 1 and wave 2 that was severely affected. RESULTS: During wave 1,840 patients, during wave 2, 144 patients, and during wave 3, two patients were diagnosed as novel influenza. Age 18-39 showed a significantly higher rate(78.7%) in the wave 1 patients group. Main clinical symptoms were cough and febrile sense in both waves. Patients with underlying medical conditions in wave 2(97 cases, 67.4%) showed a higher rate than those of wave 1(101 cases, 12.0%). Chronic obstructive pulmonary disorder was the most closely related underlying disorder in wave 2(18.8%). Patients requiring admission(37.5%) and ventilatory care(6.9%) due to severe pneumonic symptoms showed a significantly higher rate in wave 2. Only two young patients were diagnosed as novel influenza. Both complained of mild fever and cough, which recovered spontaneously. CONCLUSION: Most cases of influenza A (H1N1) infection were uncomplicated, characterized by influenza-like symptoms and spontaneous recovery. The number of patients showed a marked decreased year by year, however, the severity of clinical presentations increased in wave 2. Young adults who did not have cross-reactive antibodies to novel influenza A (H1N1) from previous infection or immunization were dominant in wave 1. Older patients with underlying medical conditions were more likely to admitted and present fatal progress in wave 1 and wave 2. Because influenza viruses are unpredictable, continued national preparedness, flexible response, and careful monitoring are essential.
الموضوعات
Humans , Young Adult , Antibodies , Cough , Emergencies , Emergency Service, Hospital , Epidemiology , Fever , Immunization , Influenza A Virus, H1N1 Subtype , Influenza, Human , Korea , Medical Records , Observational Study , Orthomyxoviridae , Pandemics , Pneumonia , Respiration, Artificialالملخص
PURPOSE: Delirium is a common and worrisome problem among elder hospitalized patients. Many studies have sought to evaluate the risk factors of delirium. Most of these studies have dealt with the intensive care unit, with virtually nothing known about the emergency room. Our study was designated to evaluate the risk factors in an emergency department. METHODS: We retrospectively reviewed 414 cases of elder patients admitted to the general ward of internal medicine via the emergency room between January 2009 and December 2009. We divided these patients into a delirium group and non-delirium group. We statistically evaluated 31 known risk factors of delirium in these two groups. RESULTS: Using chi-square test, 14 of 31 known risk factors of delirium were proven as risk factors of delirium in an emergency room. Using logistic regression, three of the 14 proven risk factors were revealed as prior factors. CONCLUSION: A variety of factors of delirium are risk factors of delirium in an emergency room. A few important known risk factors are failed to pass statistically evaluation. These results are influenced by cultural pecularities of South Korea. Also, the small sample size limited conclusive evaluation. Nonetheless, the importance of patients' past medical history, laboratory results, and choice of medication when treating elder hospitalized patients to prevent delirium is likely important in reducing mortality and morbidity.
الموضوعات
Aged , Humans , Delirium , Emergencies , Intensive Care Units , Internal Medicine , Logistic Models , Patients' Rooms , Republic of Korea , Retrospective Studies , Risk Factors , Sample Sizeالملخص
Carbon dioxide (CO2) poisoning is rare, but its clinical features of acute exposure include cardiovascular, respiratory, neurologic and metabolic aspects. CO2 can also have a direct toxicological effect. At very high concentrations (>9%), CO2 induces respiratory depression and narcotic-like effects on the central nervous system. Especially, acute poisoning from dry ice is caused by CO2 gas inhalation and asphyxiation, and may impose excess load on the myocardium. This case was an acute CO2 poisoning from dry ice gas inhalation. In spite of an initial severe status, the male patient rapidly improved with no complications following the application of highly concentrated oxygen and fluid therapy.
الموضوعات
Humans , Male , Carbon , Carbon Dioxide , Central Nervous System , Dry Ice , Fluid Therapy , Inhalation , Myocardium , Oxygen , Respiratory Insufficiencyالملخص
PURPOSE: Pneumonia is the most common cause of death among infectious diseases. Community-acquired pneumonia is the sixth leading cause of death in Korea. This study was designed to analyze the relationship of risk factors and mortality, especially the pneumonia severity index (PSI) in patients with community-acquired pneumonia diagnosed in the emergency department of a referral hospital. METHODS: The medical records of patients admitted to the Yeungnam University Hospital between March 2006 and March 2008 for community-acquired pneumonia were reviewed retrospectively. The demographic data, comorbidity, laboratory results, PSI score and class of PSI, all of which might influence the prognosis of pneumonia, were analyzed. RESULTS: Among 123 patients admitted for community-acquired pneumonia, 18 died (mortality rate of 15%). Laboratory data showed that sodium, glucose, blood urea nitrogen, albumin, platelets, hematocrit and arterial pH were related to the prognosis. For the pneumonia severity index, the mortality rate increased in a step-wise manner from class I through class V. Comorbidities such as neoplasms (p=0.000), cerebrovascular accidents (p=0.005) and liver disease (p=0.003), as well as systolic blood pressure (p=0.003), respiratory rate (p=0.024), sodium (p=0.000), glucose (p=0.000), blood urea nitrogen (p=0.000), albumin (p=0.003), hematocrit (p=0.000) and arterial pH (p=0.042) were the important risk factors for mortality in patients with community-acquired pneumonia. CONCLUSION: The pneumonia severity index could be used as a valuable index for predicting mortality of patients and the prognosis of community-acquired pneumonia in the emergency department.
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Humans , Blood Glucose , Blood Platelets , Blood Pressure , Blood Urea Nitrogen , Cause of Death , Communicable Diseases , Comorbidity , Emergencies , Glucose , Hematocrit , Hydrogen-Ion Concentration , Korea , Liver Diseases , Medical Records , Nitrogen , Pneumonia , Prognosis , Referral and Consultation , Respiratory Rate , Retrospective Studies , Risk Factors , Sodium , Stroke , Ureaالملخص
PURPOSE: Inappropriate use or misuse of emergency medical services (EMS) is a potential waste of resources and a possible diversion of needed service from another patient in need. One of the most serious consequences of inappropriate use of EMS is emergency department crowding. The purpose of this study was to evaluate the appropriateness of EMS use and the propensity of local residents in Daegu to choose particular hospitals. METHODS: We obtained study data from Jan. to Feb. 2009 using a prospective survey of patients or their companies that had used EMS. The survey was done by a senior emergency physician who rode in an ambulance with 119 crew members during on-scene assessments and en route to the hospital. The severity of illness/injury was evaluated using the START system/CRAMS scale. We analyzed the appropriateness of EMS use and hospital transport in relation to the severity of the patients problem. We also identified factors that directly influence choice of hospitals. RESULTS: Forty-six cases (36.8%) chose an inappropriate hospital. In 89 cases (71.2%), choice of hospital was done by the patient or his guardian. The most common factor that directly influenced hospital choice was the hospital the patients identified with (50%). Appropriateness of transport to the hospital correlated with problem severity evaluated by the EMS team and by trauma patients (p<0.05). Transport to a higher level hospital (39%) was selected about ten fold more often than transport to a lower level hospital (4%). CONCLUSION: The appropriateness of local EMS use should be improved with respect to many factors. Local residents have a propensity to choose a large or university hospital for a variety of reasons. Local residents should be continuously educated for appropriative EMS use.
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Humans , Ambulances , Crowding , Emergencies , Emergency Medical Services , Prospective Studies , Transportation of Patientsالملخص
PURPOSE: Many of the febrile diseases developing in Korea during the autumn are tsutsugamushi disease. The pathogen of the disease is rickettsia of oriental tsutsugamushi. The aim of this research was to help in the early diagnosis and treatment by analyzing the clinical features of patients with tsutsugamushi disease and the factors affecting the duration of antibiotic use and admission. METHODS: A total of 177 patients diagnosed with tsutsugamushi disease who visited the emergency department between 2004 and 2008 were included. We retrospectively reviewed the medical records on OCS by comparing the relationship between clinical features and the duration of antibiotic use or admission. RESULTS: In the outbreaks occurring in 2005 and 2007 no significant clinical differences were seen. Tsutsugamushi disease occurred in females(61.0%), the elderly (over 60 years old, 66.1%), and urban areas(56.5%). Common clinical findings were eschar(80.8%) and skin rash(96.6%). Complications(58.8%) included pneumonia, meningitis, DIC, and acute renal failure. The duration of antibiotic use was increased with increasing age over 60 years old and with increasing body temperature. The duration of admission was significantly correlated with the absence of eschar, age over 40 years old, and abnormal findings of BUN/Cr, PT/PTT, albumin. CONCLUSION: In conclusion, several factors such as age, hemoglobin, eschar, BUN/Cr, albumin and PT/PTT were correlated with the duration of antibiotic use and admission. Therefore, efforts to reduce them are required
الموضوعات
Aged , Humans , Acute Kidney Injury , Body Temperature , Dacarbazine , Disease Outbreaks , Early Diagnosis , Emergencies , Hemoglobins , Korea , Length of Stay , Medical Records , Meningitis , Pneumonia , Retrospective Studies , Rickettsia , Scrub Typhus , Skinالملخص
PURPOSE: To compare the usefulness of Macintosh laryngoscope with GlideScope(R) video laryngoscope in five airway scenarios on Simman(R) manikin. METHODS: Forty medical students, 20 males and 20 females, were enrolled and performed endotracheal intubation with Macintosh laryngoscope and GlideScope(R) video laryngoscope in five airway scenarios: normal airway, cervical rigidity, tongue edema, pharyngeal obstruction and combined tongue edema with pharyngeal obstruction. We studied the laryngeal view, ease of intubation, time for intubation, success rate and number of attempts in the five airway scenarios. RESULTS: VAS for the ease of intubation showed that intubation with GlideScope(R) video laryngoscope was easier than intubation with Macintosh laryngoscope in each scenario except the cervical rigidity scenario (p<0.05). The laryngeal view with GlideScope(R) video laryngoscope was better than that with Macintosh laryngoscope in each scenario except the pharyngeal obstruction scenario (p<0.05). The time for visualizing epiglottis with Macintosh laryngoscope was shorter than with GlideScope(R) video laryngoscope except the tongue edema and pharyngeal obstruction scenario (p<0.05). The time from visualizing epiglottis to insertion of endotracheal tube with Macintosh laryngoscope was shorter than with GlideScope(R) video laryngoscope except the tongue edema and combined scenario (p<0.05). The total time for endotracheal intubation with Macintosh laryngoscope was shorter than with GlideScope(R) video laryngoscope except the tongue edema scenario (p<0.05). The success rate with GlideScope(R) video laryngoscope was higher than with Macintosh laryngoscope in the tongue edema and combined scenario (p<0.05). There was no statistical significance for the number of attempts between GlideScope(R) video laryngoscope and Macintosh laryngoscope. CONCLUSION: Endotracheal intubation with GlideScope(R) video laryngoscope had better results than with Macintosh laryngoscope in most scenarios. Endotracheal intubation with GlideScope(R) video laryngoscope promises to be a useful device for non-skilled personnel.
الموضوعات
Female , Humans , Male , Edema , Epiglottis , Intubation , Intubation, Intratracheal , Laryngoscopes , Manikins , Students, Medical , Tongueالملخص
Inappropriate use or misuse of EMS (Emergency Medical Service) is a potential waste of resources and diversion of needed service from another in need. One of the most serious consequences of an inappropriate use of EMS is emergency department (ED) overcrowding. ED overcrowding in large hospitals, especially university hospitals, has been a persistent and unsolvable problem worldwide. The issues have drawn the attention of media and have been discussed in many conferences. Currently, various studies have identified the causes and suggested the solutions for these problems. The inappropriate use of EMS are mainly caused by the misguidance of EMS providers and misuse of the public user. In order to solve this problem, the EMS system provider should make an effort to improve and develop the system. The government will also need to step up publicity activity on the awareness for an appropriate use of EMS system through mass media. ED overcrowding are caused by misuse of both EMS and medical transfer system. And inefficiency of hospital operating system is another cause. The hospital and its ED have to respond more rapidly to eliminate the unnecessary wait time of ED patients. Relocation of boarding ED patient to other inpatients area, such as hallways, conference rooms, is the first thing to do. To improve the flow of ED patients, the persons in charge of every department will have to come together to coordinate the early discharge of hospital patients and the scheduling of elective and surgical patients. The suggested solutions must be put in practice immediately.
الموضوعات
Humans , Congresses as Topic , Emergencies , Emergency Medical Services , Fees and Charges , Hospitals, University , Inpatients , Korea , Mass Mediaالملخص
BACKGROUND: The causes of chest pain vary but the leading cause of chest pain is ischemic heart disease. Mortality from ischemic chest pain has increased more than two fold over the last ten years. The purpose of this study was to determine the data necessary for rapid treatment of patients with signs and symptoms of ischemic chest pain in the emergency department (ED). MATERIALS AND METHODS: We interviewed 170 patients who had ischemic chest pain in the emergency department of Yeungnam University Hospital over 6 months with a protocol developed for the evaluation. The protocol used included gender, age, arriving time, prior hospital visits, methods of transportation to the hospital, past medical history, final diagnosis, and outcome information from follow up. RESULTS: Among 170 patients, there were 118 men (69.4%) and the mean age was 63 years. The patients diagnosed with acute myocardial infarction (AMI) were 106 (62.4%) and with angina pectoris (AP) were 64 (37.6%). The patients who had visited another hospital were 68.8%, twice the number that came directly to this hospital (p0.05). The patients who had a total time delay of over 6 hours was similar 54.8% in the AMI group and 57.9% in the AP group (p>0.05). As a result, only 12.2% of the patients with an AMI received thrombolytics, and 48.8% of them had a simultaneous percutaneous coronary intervention (PCI). In the emergency department 8.5% of the patients with an AMI died. CONCLUSION: Timing is an extremely important factor for the treatment of ischemic heart disease. Most patients arrive at the hospital after a long time lapse from the onset of chest pain. In addition, most patients present to a different hospital before they arrive at the final hospital for treatment. Therefore, important time is lost and opportunities for treatment with thrombolytics and/or PCI are diminished leading to poor outcomes for many patients in the ED. The emergency room treatment must improve for the identification and treatment of ischemic heart disease so that patients can present earlier and treatment can be started as soon as they present to an emergency room.
الموضوعات
Humans , Male , Angina Pectoris , Chest Pain , Diagnosis , Emergencies , Emergency Service, Hospital , Follow-Up Studies , Mortality , Myocardial Infarction , Myocardial Ischemia , Percutaneous Coronary Intervention , Thorax , Transportationالملخص
PURPOSE: Cytokines and chemokines are essential in neuronal development and play important roles in both acute and chronic inflammatory reactions in the central nerve system and peripheral tissues. Thus, they may perform key functions in the pathophysiology of acute ischemic and hemorrhagic brain injury. The aim of this study was to evaluate the production of chemokines following acute brain injury (ABI) in humans. The correlations between the three main types of ABI(traumatic, ischemic and spontaneous hemorrhagic brain injury) and the plasma levels of three chemokines-CXCL8 (IL-8), CCL4 (MIP-1beta) and CCL5 (MIP-1beta)-were analyzed. METHODS: Enrolled in this study were 25 patients with isolated severe head trauma, 31 patients with spontaneous intracranial hemorrhage (SIH), and 34 patients with cerebral infarction. The AIS(abbreviated injury scale) was used to identify the isolated severe head trauma patients. The severities of several types of injury were assessed by ISS (injury severity score) in trauma, GCS (Glasgow coma scale) in SIH, and NIHSS(national institute of health stroke scale) in cerebral infarction. Blood samples from 9 healthy blood donors were analyzed as controls. Protein concentrations of CXCL8, CCL4, and CCL5 were measured by ELISA(enzyme-linked immunosorbent assay), and mRMA levels of XCL1(lymphotactin, Ltn), CCL5, CXCL10 (IP-10), CCL4, CCL3(MIP-alpha), CCL2 (MCP-1), CXCL8, and CCL1 (I-309) were evaluated using the RPA(multi-probe RNase protection assay) system in plasma and in peripheral blood mononuclear cells (PBMCs) from patients' venous blood obtained with 24 hours after injury. RESULTS: The expression patterns of XCL1, CCL5, CXCL8, CCL4, and CCL5 mRNA were similar in the three groups of ABI, without differences related to patterns of ABI or trauma severity. Concentrations of the three proteins CXCL8, CCL4, and CCL5 in plasma from all three ABI groups were higher than in the control group. The level of CXCL8 was significantly elevated in the TBI(traumatic brain injury) group (3.57+/-5.93 pg/ml, p<0.05), and this high level of IL-8 was significantly correlated with increased injury severity (high ISS and low GCS score) (p<0.05). The concentration of CCL4 was highest (29.82+/-17.94 pg/ml) in the ischemic brain injury group and was significantly higher than in the SIH group (p<0.05). The protein level of CCL4 was also elevated significantly with high ISS (p<0.05). The level of CCL5 was highest (7692+/-3603 pg/ml) in the SIH group and was significantly higher than in the TBI group (p<0.05). CONCLUSION: ABI resulted in a modest activation of CXCL8, CCL4 and CCL5, and the statistically significant correlations were found between the plasma levels of these chemokines and ABI. In addition, significant correlations were found between the plasma protein levels of CXCL8 and CCL4 and trauma severity in TBI group. Therefore, the continuous monitoring of various chemokine concentrations may provide a useful adjunct to assigning grouping and to gauging severity or prognosis in ABI.
الموضوعات
Humans , Blood Donors , Brain , Brain Injuries , Cerebral Infarction , Chemokines , Coma , Craniocerebral Trauma , Cytokines , Interleukin-8 , Intracranial Hemorrhages , Neurons , Plasma , Prognosis , Ribonucleases , RNA, Messenger , Strokeالملخص
Iatrogenic pneumothorax is occasionally caused by invasive medical or surgical procedures in the chest that include fine needle aspiration biopsy, placing a central venous catheter, or insertion of a pleural drain. A 19-year-old male was admitted due to persistent pleuritic right-side chest pain after operation on a fractured clavicle by K-wire. He did not complain of dyspnea or coughing but had experienced chest pain for several days. On physical examination, the patient's breathing sound was slightly decreased in the right lung field. A Chest X-ray was taken, revealing a small degree of pneumothorax at the right apex and an approximately 9 cm-sized linear metallic foreign body at the diaphragm level. A chest CT was then taken, and on lung setting view the object was seen to extend from the right retrocrural space, penetrating the diaphragm and right lung parenchyme, to the IVC and a minimal hemopneumothorax at right. The patient was operated on in the thoracic surgery department for the purpose of simple removal of the foreign body (K-wire). Afterward, he was discharged without specific complaints on the 8th day from admission. In summary, we report a case of uncommon iatrogenic pneumothorax caused by migration of a K-wire into the pleural cavity.
الموضوعات
Humans , Male , Young Adult , Biopsy , Biopsy, Fine-Needle , Bone Wires , Central Venous Catheters , Chest Pain , Clavicle , Cough , Diaphragm , Dyspnea , Foreign Bodies , Hemopneumothorax , Iatrogenic Disease , Lung , Physical Examination , Pleural Cavity , Pneumothorax , Respiratory Sounds , Thoracic Surgery , Thorax , Tomography, X-Ray Computedالملخص
Chylothorax after blunt chest trauma is very rare and is generally caused by injuries to the thoracic duct or its major tributaries. Such an injury can cause a fistula, a localized collection of chyle known as a chyloma, or an intrapleural collection referred to as a chylothorax. We report a case of chylothorax attributed to thoracic duct injury after an in-car traffic accident, accompanied by nephrotic syndrome diagnosed after admission. An 11-year-old male was admitted because of dyspnea developed three days previously after an in-car traffic accident. He also complained of nausea, vomiting, and abdominal discomfort after meals. We took chest X-ray films and a chest CT scan in the emergency department, which showed pleural effusion on both sides and massive ascites. Diagnostic thoracentesis was then done, the aspirated fluid showed a milky-white appearance and fluid analysis showed chyle. Tube thoracostomy with fluid and nutritional support was administered but a week later the patient was more edematous and laboratory results revealed nephrotic features. After a further ten days, the patient was discharged with some symptomatic improvement, not confirmed by pathologic diagnosis.
الموضوعات
Child , Humans , Male , Accidents, Traffic , Ascites , Chyle , Chylothorax , Diagnosis , Dyspnea , Emergency Service, Hospital , Fistula , Meals , Nausea , Nephrotic Syndrome , Nutritional Support , Pleural Effusion , Thoracic Duct , Thoracostomy , Thorax , Tomography, X-Ray Computed , Vomiting , Wounds, Nonpenetrating , X-Ray Filmالملخص
PURPOSE: The development of a social system or a national economic state is accompanied by a proportional increase in the number of the aged. As the social activity of geriatric people increase, the frequency of traumatic injury also increases. In this study, to prevent geriatric trauma and to reduce medical expenses, we analyzed the factors that influence the incidence and the severity of geriatric trauma and the correlation between the factors. METHOD: The subjects of our investigation ware trauma patients over sixty-five years old who visited the Emergency Department of Yeungnam University Hospital during a period from January 1, 2003, to December 31, 2003. We retrospectively reviewed the medical charts of 436 geriatric trauma patients, and we analyzed the data by using SPSS 12.0 for Window(R). RESULT: The average age was 72.8 years, and the ratio of males to females was 1:1.1. The mean Injury Severity Score(ISS) was 10.8, and no difference was found between male and female. The mean hospitalization days were higher in patients who had a past medical history or who had a complications. Slips were the most common cause of trauma(199, 44.3%). Bicycle accidents and cultivator accidents were more common for males, but slips were more common for females. Bicycle accidents and in-car traffic accidents tended to cause longer hospitalization days. The largest number of aged trauma patients, 46, occurred during May and the smallest number, 24, during December. In addition, summer had the largest number of aged trauma patients, 93. The types of trauma, ISS, and numbers of patients did not correlate with season. The number of patients was increased on partly cloudy days, and the incidence of complication was increased in cultivator accident patients. CONCLUSION: Aged trauma patients who visit the ED for trauma must not overlook on the basis of their normal vital signs. For males, safety education is required when riding bicycles, motorcycles and cultivators. For females, encouragement to use walking aids that can prevent slips will reduce the occurrence of injury. Patients who visit by in-car TA, cultivator accidents, or bicycle accidents or who have a past medical history need to be give more care to reduce complications after hospitalization. Additionally, many side efforts must be initiated in order to reduce trauma in aged people.