الملخص
This study aimed to investigate the serum levels of the cytokine TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in patients with toxoplasmosis retinochoroidits (TR) and controls. 37 patients with TR and 30 subjects with positive serology for toxoplasmosis but without history and signs of uveitis were included in this study. Serum concentrations of TNF-α, sTNFR1, and sTNFR2 were determined by ELISA. Serum concentrations of TNF-α and sTNFR1 were similar in controls (mean ± SD median values; 56.57 ± 141.96 and 504.37 ± 163.87, respectively) and TR patients (mean ± SD values, 121.62 ± 217.56 and 511.15 ± 189.30, respectively). Serum concentrations of sTNFR2 were higher in the uveitis group when compared to the control group (respectively, mean ± SD values, 1734.84 ± 379.32 and 1442.75 ± 309.47; p=0.002). There was no association between the serum levels of the molecules and the time of first symptoms, severity of vitreous haze, size or localization of active lesions, levels of visual acuity, and presence of vasculitis. These results suggest that TR is associated with changes in the circulating levels of inflammatory biomarkers, but they are not correlated with local/ocular signs.
الموضوعات
Adult , Female , Humans , Male , Chorioretinitis/blood , Receptors, Tumor Necrosis Factor, Type I/blood , Receptors, Tumor Necrosis Factor, Type II/blood , Toxoplasmosis, Ocular/blood , Tumor Necrosis Factor-alpha/blood , Biomarkers/blood , Case-Control Studies , Chorioretinitis/parasitologyالملخص
Os autores relatam um caso de vasculite retiniana aguda bilateral em uma paciente de 31 anos de idade, que apresentou, em um dos olhos acometidos, um aspecto fundoscópico semelhante ao quadro descrito na literatura como "periflebite retiniana aguda congelada" ou "angelite de ramos congelados".
الموضوعات
Humans , Female , Adult , Cytomegalovirus Retinitis/complications , Cytomegalovirus Retinitis/diagnosis , Cytomegalovirus Retinitis/therapy , Retinal Diseases/complications , Retinal Diseases/etiology , Retinal Diseases/therapy , Fluorescein Angiographyالملخص
Foram examinados 997 pacientes hansenianos de controle ambulatorial, sendo que 528 (53%) eram da forma Virchowiana, 199 (20%) da forma Dimorfa, 167 (16,8%) da forma Tuberculoide e 103 (10,3%) da forma Indeterminada. 314 pacientes (31,5%) apresentavam alteraçöes do bulbo ocular, e essas manifestaçöes foram mais frequentes na forma Virchowiana e aumentaram de acordo com a idade do paciente e duraçäo da doença. Lesöes oculares severas foram achados raros e essa baixa incidência foi atribuída, em parte, ao tratamento sistêmico precoce
الموضوعات
Humans , Male , Female , Adult , Middle Aged , Blindness/prevention & control , Eye/injuries , Leprosy/etiology , Brazilالملخص
Os AAs realizaram Punçäo de Câmara Anterior em uma paciente portadora de Hanseníase, com quadro de iridociclite bilateral. A Punçäo foi realizada sob anestesia tópica, em regime ambulatorial, e o humor aquoso foi submetido à coloraçäo pelo método de Ziehl-Nielsen, tendo sido isolado o M. Leprae na Câmara Anterior. O trabaho mostra que o M.Leprae é uma das causas de uveítes na Hanseníase, merecendo ser procurado em casos de uveítes em pacientes portadores de Hanseníase