الملخص
Objectives: Diabetic dyslipidaemia (DD) is characterised by hypertriglyceridaemia and elevated or normal levels of low-density lipoprotein cholesterol and decreased levels of high-density lipoprotein cholesterol with Type 2 diabetes mellitus. Statins and anti-diabetic medication are coprescribed for optimal control. Materials and Methods: The objective of the study was to compare the safety and efficacy of Saroglitazar 4-mg and Fenofibrate 200 mg in combination with low dose Atorvastatin (10 mg) in patients with DD. Run-in period of 4 weeks for life-style and diet modification followed by 12 weeks of treatment with saroglitazar or fenofibrate and low dose of atorvastatin was followed. Primary outcome of this study was an absolute change in serum triglyceride level at baseline and end of treatment period (12 weeks). Secondary outcome was changed from baseline lipid profile, fasting blood glucose and glycosylated haemoglobin (HbA1c) at the end of treatment period. Safety assessment was also done during the duration of study. Results: Forty patients of DD were randomly divided into two groups. One group received Saroglitazar 4 mg along with Atorvastatin 10 mg. Patients in second group received Fenofibrate 200 mg along with Atorvastatin 10 mg. Improvement in deranged lipid levels in both the groups was observed and this difference in improvement statistically was not found to be significant. We also observed that Saroglitazar significantly improves glycaemic profile by decreasing fasting blood sugar levels and HbA1c (P = 0.01, P < 0.01). Adverse events reported during this study were mild and none of the patients reported serious adverse events. Conclusion: Saroglitazar could be a potential drug to control both hyperglycaemia and dyslipidaemia in patients with DD.
الملخص
Introduction: Government of India launched an Aadhar-linked Direct Benefit Transfer (DBT) scheme from 1st April, 2018. Under this scheme, all notified TB patients would receive Rs 500 per month (~US$7) throughout the course of their treatment for nutritional support. Aim and Objectives: To determine the challenges faced by the health providers and patients in the implementation of Direct Benefit Transfer scheme. Methods: This was a mixed method cross-sectional study conducted on all public and private TB patients notified during the year 2019 under RNTCP (now NTEP) in district Amritsar, Punjab. Quantitative data about the availability and validation of bank accounts was obtained from the Nikshay portal after having permission from the District TB Officer. Qualitative data was obtained from the focus group discussion and in-depth interviews with the involved staff members (17) and patients (20) registered in Tuberculin units of Amritsar. Results: From the Nikshay reports, it was observed that there was significant difference between the public and private sector and between rural and urban areas. Focus group discussion was done with the TB Health Visitor (TBHV) and Senior TB supervisors (STS) and asked about the hurdles they faced. Items were identified and tabulated. In-depth interviews were conducted on 20 patients, 10 each from public and private sector respectively. Data collected was transcribed and arranged as per the themes or questions and then the information was recorded under those sub-headings. Conclusion: The major challenges observed by the providers were lack of support from the private sector, lack of awareness among people, technical issues and more work burden. Patients mostly mentioned about confidentiality issues, lack of awareness, social stigma of the disease, less amount and long and complex process.
الملخص
A 36-year-old male presented with history of injury in the left eye 3 years back with a copper wire. Examination revealed the presence of typical sunflower cataract with golden yellow deposits over the anterior lens capsule with dull glow and old vitreous hemorrhage. Non-contrast computerized tomography revealed retained intraocular foreign body in the pars plana region. The patient underwent phacoemulsification with intraocular lens implantation followed by pars plana vitrectomy and foreign body removal. Intraoperatively, fleck-like deposits were noted on the retinal surface in a circinate manner around the fovea and also over mid-peripheral retina. Postoperative swept source optical coherence tomography (SS-OCT) was performed to document the location of deposits and their characteristics. Limited literature exists regarding SS-OCT characteristics of ocular chalcosis.
الملخص
The aim of this study is to present the status of transfusion –transmitted infections among the apparently healthy donors so as to increase the awareness of complications of blood transfusion and make the clinicians more vigilant with regard to judicious use of blood. A total of 5008 units of donor’s blood was screened from January 2006 to December 2008 at blood bank of People’s Hospital, Bhopal. The result of screening showed total seropositive samples for hepatitis B (2.9%), hepatitis C (0.57%), human immunodeficiency virus (HIV; 0.51% ) and Venereal Disease Research Laboratory Test (VDRL; 0.23%) by using enzyme linked immunosorbent assay (ELISA ) methods, and rapid plasma regain (RPR) method for syphilis.
الموضوعات
Torque teno virus , Acquired Immunodeficiency Syndrome , Enzyme-Linked Immunosorbent Assay , Blood Transfusionالملخص
A case of primary lymphoma of the liver who presented with a rapidly increasing mass in the right upper abdomen is reported. Histological examination confirmed the diagnosis of diffuse, intermediate cell type of Non Hodgkins Lymphoma and was identified as "B" cell type by the use of specific monoclonal antibodies. The case is being reported for its rarity and the clinical importance of recognizing such cases because of excellent prognosis.
الموضوعات
Humans , Liver Neoplasms/pathology , Lymphoma, B-Cell/pathology , Lymphoma, Non-Hodgkin/pathology , Male , Middle Agedالملخص
The purpose of the present study was to test the efficacy of oral-transmucosal route of administration of midazolam in young potentially un-cooperative children. A sample of 40 children up to 4 years of age with ASA I status were randomly divided into experimental and control groups of 20 each. The children in experimental group received 0.5-mg/kg-body weight midazolam mixed in strawberry syrup via the oral-transmucosal route and those in control group were given the same syrup diluted with normal saline. A class II amalgam restoration was performed and routine behavior management techniques were employed in both groups. It was found that the number of procedures successfully completed and sedation produced 15 minutes after test solution administration was significantly greater in the experimental group compared to the control group. The total treatment time was also much lesser in the experimental group children. There was no significant difference in the acceptability of the test solutions in the children of the two groups.
الموضوعات
Administration, Oral , Anesthesia, Dental/methods , Child, Preschool , Conscious Sedation/methods , Dental Care for Children/methods , Dental Restoration, Permanent , Double-Blind Method , Female , Humans , Hypnotics and Sedatives/administration & dosage , Male , Midazolam/administration & dosage , Mouth Mucosaالملخص
Two rare cases of malignant melanoma, (one amelanotic) arising in the vagina in middle-aged group are being reported. Clinical, histopathological and immunohistochemical studies supported the diagnosis. The neoplasm is highly malignant & carries a poor prognosis.
الموضوعات
Female , Humans , Melanoma/pathology , Middle Aged , Vaginal Neoplasms/pathologyالملخص
Acute Erythroleukemia is a rare disorder of hematopoietic system, accounts for 1-3% of all acute leukemia and 15% of myeloid leukemia. Recently, the World Health Organisation & Society of Haematopathology proposed a change in the categorization, with M6a and M6b subgroups of the original FAB classification. Hereby we report a case of acute erythroleukemia--M6b subtype, presented with pain abdomen and vomiting. The patient died within two days. The case is being reported for its rarity and uncommon presentation.
الموضوعات
Fever , Hepatomegaly , Humans , Leukemia, Erythroblastic, Acute/classification , Male , Middle Aged , Splenomegalyالملخص
Cystic change in Schwannoma is uncommon with very few cases reported in literature till date. We present a case clinically mimicking a soft tissue sarcoma but diagnosed on histopathology as cystic schwannoma.
الموضوعات
Aged , Arm , Cysts/pathology , Female , Humans , Neurilemmoma/pathology , Soft Tissue Neoplasms/pathologyالملخص
Various hypofractionated radiotherapy schedules of radiotherapy have been tried in patients of advanced NSCLC with no conclusive superiority of either a more protracted low dose per fraction schedule or a rapid course of large fraction size. Present study evaluates the role of weekly high dose radiotherapy for the palliation of various intrathoracic symptoms like cough, chest pain, hemoptysis, dyspnoea. A total of 47 patients of advanced non-small cell lung cancer were treated with four weekly fraction of 5 Gy to a total dose of 20 Gy. Mean age at presentation was 53 years. Majority of patients had stage III disease. Pain relief was seen in 77% (23/30) patients with complete relief in 57%; haemoptysis was completely relieved in 77% patients (17/22); and cough was relieved in 68% (19/28) patients. Complete relief from dyspnoea was seen in only 5/12 (42%) patients whereas 2/12 (17%) patients had partial response. The present regime of 20 Gy in four weekly fractions was well tolerated by the patients without any identifiable acute toxicity and was simple and convenient to the patients, who traverse a long distance for radiotherapy in India. To conclude, weekly schedule af EBRT provide effective palliation of various intrathoracic symptoms in the patients with advanced NSCLC.
الموضوعات
Adult , Aged , Carcinoma, Non-Small-Cell Lung/mortality , Dose Fractionation, Radiation , Female , Humans , Lung Neoplasms/mortality , Male , Middle Aged , Palliative Care/methods , Prognosis , Survival Rate , Treatment Outcomeالملخص
We report a case of atypical lipomatous tumor-sclerosing type, a rare retroperitoneal soft tissue liposarcoma, presented with vague musculoskeletal symptoms. Patient was managed with complete resection of the tumor mass with adjuvant chemotherapy. The patient is doing well, with no evidence of recurrence 22 months after the treatment.
الموضوعات
Adult , Female , Humans , Liposarcoma/pathology , Retroperitoneal Neoplasms/pathologyالملخص
Malignant mesenchymal tumours of the breast are rare neoplasms. Their incidence varies from 1%-3% of all malignant breast tumours (1). Stromal sarcoma of the breast is an extremely uncommon tumour (2). We present a rare case of advanced stromal sarcoma of the breast successfully managed with radical surgery and radiotherapy.
الموضوعات
Adult , Breast/pathology , Breast Neoplasms/pathology , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Mesenchymoma/pathology , Sarcoma/pathologyالملخص
Leiomyosarcoma is an uncommon malignant tumour of the pancreas. Many retroperitoneal leiomyosarcomas grow silently and are extremely large when diagnosed. We report a 45 year old lady who presented with abdominal lump and haemoptysis. Ultrasound guided biopsy of the mass revealed a pancreatic leiomyosarcoma. The patient had lung metastasis and received chemotherapy. She is alive with disease at last followup.
الموضوعات
Diagnosis, Differential , Female , Humans , Leiomyosarcoma/diagnosis , Lung Neoplasms/secondary , Middle Aged , Pancreatic Neoplasms/diagnosisالملخص
From January 1993 to December 1995, complete records of patients with biliary neoplasms were analysed. A total of 124 patients were registered. Majority of patients were in the age range of 40-60 years (median 54 years). There were 38 males and 86 females. Histopathologically, adenocarcinoma was the commonest type (59%). Pain, jaundice and lump were noticed in 119, 54 and 77 patients respectively. Fifty six patients had associated gall stones. Ninety patients had metastatic disease at presentation. Majority of them (110/124) had advanced, inoperable disease and therefore were considered for palliative treatment. Only 14 patients (12%) were considered for curative treatment. Of these 14 patients, all the cases underwent surgery, 10 received radiotherapy and 10 received chemotherapy. Follow up was very poor. The survival of 14 patients, who received curative treatment, ranged from 2 months to 44 months with mean of 16 months.
الموضوعات
Adenocarcinoma/diagnosis , Biliary Tract Neoplasms/diagnosis , Female , Humans , India/epidemiology , Male , Middle Aged , Retrospective Studiesالملخص
Despite improvement in the diagnostic modalities, surgical technique, chemotherapy and radiotherapy, mortality and morbidity due to carcinoma esophagus continues to be dismal. Combination of external and intraluminal radio therapy (ILRT) has emerged as a powerful and promising palliative therapy in this disease. Thirty four patients with inoperable cancer esophagus treated with ILRT during June 1991 to December 1993 were evaluated to assess its palliative effects. Seventeen of these patients had received additional chemotherapy and external radiotherapy. Thirteen patients received only radiotherapy (both external radiotherapy + ILRT) and the remaining 4 received only ILRT. They were followed up for a mean period of 8.3 months (range 2 to 28 months) during which one patient was lost to follow up. Eight had a follow up of less than 6 months. Eight (33%) amongst the remaining 25 patients were considered disease free, 15 had recurrent and progressive disease, one developed metastasis and one patient died. In 21 (66%) dysphagia markedly improved. Nine (26%) patients survived beyond 1 year and the median survival for all patients was 8 months. Associated radiation morbidity was documented in 13 (38%) patients. We conclude that combination of external radiotherapy and ILRT is an effective and safe therapy for inoperable esophageal malignancies.
الموضوعات
Brachytherapy , Carcinoma/drug therapy , Cesium Radioisotopes/therapeutic use , Chemotherapy, Adjuvant , Cisplatin/therapeutic use , Esophageal Neoplasms/drug therapy , Female , Follow-Up Studies , Humans , Male , Methotrexate/therapeutic use , Middle Aged , Palliative Care , Radiotherapy, High-Energy , Time Factorsالملخص
Vecuronium, a monoquaternary analogue of pancuronium, the neuromuscular blocker, was compared with pancuronium in 50 patients undergoing elective closed mitral valvotomy. The patients were randomly divided into two groups of 25 each, and the muscle relaxants were administered in a dose of 0.1 mg/kg body weight. Both the agents produced identical intubating conditions at 3 min. Vecuronium showed a significantly shorter onset of action, as compared to pancuronium. The latter significantly increased the heart rate throughout the period of study whereas vecuronium significantly decreased the heart rate, 25 min after administration. There was significant increase in the mean arterial pressure (MAP) at tracheal intubation in both the groups, which persisted throughout the period of study in pancuronium group. There was a significant fall in MAP at 30 min after relaxant in vecuronium group. The incidence of arrythmias was similar and significant in both the groups. Vecuronium, thus showed a quicker onset of action with minimal haemodynamic effects, as compared to pancuronium in patients undergoing closed mitral valvotomy.
الموضوعات
Adolescent , Adult , Blood Pressure/drug effects , Female , Heart Rate/drug effects , Humans , Intubation, Intratracheal , Male , Middle Aged , Mitral Valve/surgery , Neuromuscular Junction/drug effects , Pancuronium/administration & dosage , Time Factors , Vecuronium Bromide/administration & dosageالملخص
With the application of endoscopic retrograde cholangio pancreatography (ERCP), the association of anomalous pancreatobiliary junction and choledochal cyst is being increasingly recognized. We describe here the ERCP findings in three patients who had this anomaly in association with fusiform (Type I) choledochal cyst. Two of our patients also had evidence of pancreatitis. The importance of ERCP in the preoperative assessment of such patients is highlighted.
الموضوعات
Adolescent , Adult , Cholangiopancreatography, Endoscopic Retrograde , Choledochal Cyst/etiology , Common Bile Duct/abnormalities , Female , Humans , Male , Pancreatic Ducts/abnormalitiesالملخص
Fifteen patients with malignant biliary obstruction were subjected to fine needle aspiration cytology (FNAC) under fluoroscopic guidance. Fourteen (93%) of them were correctly diagnosed to have a malignancy at FNAC. Simultaneous with FNAC or at a later date, all the patients underwent percutaneous biliary drainage with a drop in serum bilirubin from a mean of 23.2 mg/dl to 8.5 mg/dl. Ten patients were subjected to exploratory laparotomy and biopsy at which the diagnosis of FNAC was confirmed in nine of them. The tenth patient with a negative yield at FNAC had a 1.0 cm cholangiocarcinoma. The usefulness of FNAC combined with biliary drainage as an alternative to surgery is highlighted.