الملخص
Abstract Periodontal diseases are infectious inflammatory chronic diseases of a multifactorial nature. They are primarily caused by dysbiotic ecological changes in dental biofilm, which may be influenced by risk factors. The prevention of periodontal diseases may involve different strategies focused on reducing distal, intermediate, and proximal risk factors at both the population and individual levels. Effective prevention depends on interdisciplinary and common risk factor approaches. Also, patient-centered preventive models are more effective than professional-centered models in the management of periodontal diseases. Regular and periodic control of dental biofilm is an essential measure for the different levels of prevention of periodontal diseases. The effectiveness of periodontal disease prevention largely depends on positive modifications of behavior, knowledge, health literacy, patient empowerment, motivation, and compliance.
الملخص
Abstract Objective Obesity is a chronic disease that negatively affects an individual's general and oral health. The present study aimed to compare the clinical and microbiological effects of non-surgical periodontal therapy with the full mouth disinfection (FMD) protocol on obese and non-obese individuals at 9 months post-therapy. Methodology This clinical study was first submitted and approved by the Ethics Committee. Fifty-five obese patients and 39 non-obese patients with periodontitis were evaluated. The full-mouth periodontal clinical parameters, clinical attachment level (CAL), probing depth (PD), gingival index (GI), and plaque index (PI), were monitored at baseline, 3, 6, and 9 months after periodontal treatment with full mouth disinfection (FMD) protocol. The mean count of Tannerella forsythia , Porphyromonas gingivalis , Treponema Denticola , and Aggregatibacter actinomycetemcomitans was determined by quantitative polymerase chain reaction on subgingival biofilm samples. Demographic data were assessed by Chi-square test. For clinical and microbiological parameters, two-factor repeated-measures ANOVA was used. Results In both groups, periodontal therapy using the one-stage full-mouth disinfection protocol significantly improved CAL, PD, GI, and PI (p<0.05). Obese and non-obese patients equally responded to non-surgical periodontal therapy (p>0.05). Microbial count found no major differences (p>0.05) between obese and non-obese individuals who had undergone non-surgical periodontal therapy. Conclusions Obesity did not affect the clinical and microbiological outcomes of non-surgical periodontal therapy.
الموضوعات
Humans , Male , Female , Adult , Periodontitis/microbiology , Periodontitis/therapy , Obesity/microbiology , Time Factors , Periodontal Index , Anthropometry , Dental Plaque Index , Prospective Studies , Risk Factors , Analysis of Variance , Longitudinal Studies , Treatment Outcome , Aggregatibacter actinomycetemcomitans/isolation & purification , Porphyromonas gingivalis/isolation & purification , Statistics, Nonparametric , Treponema denticola/isolation & purification , Tannerella forsythia/isolation & purification , Middle Aged , Obesity/physiopathologyالملخص
Abstract The present manuscript discussed some relevant aspects related to private sponsored clinical trials in dentistry. For decades, the academy has been the major responsible for research in Brazil. Distant from the trade sector, academic research has not always provided clear benefits to society. A key aspect of making benefits clearer is the process of scientific knowledge transference to decision-makers, which is, in fact, the ground of evidence-based dentistry. Although private sponsoring of clinical research seems to be part of the research progress of the business rates, investment in Brazil is lower than those observed in other countries. It is particularly important to understand that instead of creating its own rules, dentistry imported the high-quality standards originally designed for pharmaceutical studies. Therefore, it is critical to understand the original rules and how dental items are classified by regulatory agencies. In fact, knowledge about international and local regulation is a basic assumption in industry-sponsored research. Despite globalization, the identification of industry-sponsored studies through open access databases is still very hard and time-demanding. A common concern when conducting industry-sponsored trials is study biases. Fortunately, many relevant organizations, academic and industry groups, have been working seriously against that. Finally, for less experienced researchers, many aspects related to industry-sponsored studies - such as confidentiality, authorship, budget - are deeply discussed until a final version of the trial agreement can be written and signed, protecting all sides. In short, the scenario should be improved, but it already represents a nice opportunity for dental research.
الموضوعات
Clinical Trials as Topic , Brazil , Industryالملخص
Abstract The aim of the present study was to compare periodontal conditions between intensive care unit (ICU) in-patients and non-ICU patients through clinical and microbiological periodontal parameters. This case-control study included 88 individuals hospitalized in ICU and 176 non-hospitalized controls. All individuals underwent a complete periodontal examination and microbiological sampling. The total bacterial load and counts of Porphyromonas gingivalis, Treponema denticola and Aggregatibacter actinomycetemcomitans were evaluated using qPCR. Data were analyzed through the Chi-square, Fisher exact, and t-Student tests, and the Spearman correlation, as appropriate. The prevalence of periodontitis was 39.7% among controls and 59.0% among ICU in-patients (OR=2.18; p=0.002). ICU in-patients had a significantly higher occurrence of cardiovascular disease (p=0.002; OR=2.20) and history of periodontal disease (p=0.031; OR=1.92) than controls. Bacterial counts of A. actinomycetemcomitans, T. denticola and P. gingivalis were significantly higher in ICU in-patients with periodontitis than in controls. The correlation between periodontal parameters and microbiological findings among cases and controls showed a significant and positive correlation between: total bacteria load and % of sites with probing depth (PD) ≥ 4 mm (cases: r=0.22 and controls: r=0.13) and P. gingivalis and % sites with bleeding on probing (BOP) (cases: r=0.22 and controls: r=0.23). Thus, ICU in-patients presented a higher prevalence of periodontitis and worse periodontal condition (higher mean plaque index, BOP, clinical attachment level ≥3 mm, and sites with PD 4 to 6 mm).
Resumo O objetivo deste estudo foi comparar as condição periodontais entre pacientes internados em Unidade de terapia intensiva (UTI) e indivíduos não hospitalizados através de parâmetros periodontais clínicos e microbiológicos. Este estudo caso-controle incluiu 88 indivíduos hospitalizados em UTI e 176 controles não hospitalizados. Todos os indivíduos foram submetidos a um exame periodontal completo e amostragem microbiológica. A carga bacteriana total e as contagens de Porphyromonas gingivalis, Treponema denticola e Aggregatibacter actinomycetemcomitans foram avaliadas utilizando qPCR. Os dados foram analisados, conforme apropriado, por meio dos testes de Qui-quadrado, Fisher exato, t-Student, Mann-Whitney e correlação de Spearman. A prevalência de periodontite foi de 39,7% entre os controles e de 59,0% entre pacientes internados em UTI (OR=2,18, IC 95%: 1,29-3,68; p=0,002). Pacientes admitidos na UTI apresentram significativamente uma maior ocorrência de doença cardiovascular (p=0,002, OR=2,20) e história de doença periodontal (p=0,031; OR=1,92) do que os controles. As contagens bacterianas de A. actinomycetemcomitans, T. denticola e P. gingivalis foram significativamente maiores nos pacientes em UTI com periodontite do que nos controles. A correlação entre os parâmetros clínicos periodontais e os achados microbiológicos entre casos e controles mostrou correlação significativa e positiva entre: carga bacteriana total e % de sítios com profundidade de sondagem (PS) ≥4 mm (casos: r=0,22 e controles: r=0,13) e P. gingivalis e % de sítios com sangramento à sondagem (SS) (casos: r=0,22 e controles: r=0,23). Pacientes internados na UTI apresentaram maior prevalência de periodontite e pior condição periodontal (maior média de índice de placa, SS, de sítios com nível de inserção clínica ≥ 3mm e PS de 4 a 6 mm) do que os controles.
الموضوعات
Humans , Periodontitis , Periodontal Pocket , Case-Control Studies , Periodontal Index , Aggregatibacter actinomycetemcomitans , Periodontal Attachment Loss , Porphyromonas gingivalis , Intensive Care Unitsالملخص
O Diabetes Mellitus é uma desordem sistêmica que afeta a produção de insulina excretada pelo pâncreas e desencadeia uma série de eventos de resposta imunológica do hospedeiro fazendo com que ocorra uma alteração nos tecidos periodontais. A doença periodontal é uma desordem inflamatória que atinge os tecidos de suporte dos dentes e pode ser desencadeada pelas desordens sistêmicas previamente já instaladas. Uma ligação bidirecional entre Diabetes Mellitus e doença periodontal tem sido evidenciada nos últimos anos. Cicatrização após tratamento odontológico é prejudicada em pacientes diabéticos. Diabéticos possuem difícil cicatrização em decorrência da resposta imune deficiente, devido ao comprometimento da resposta de neutrófilos, migração e proliferação de fibroblastos e angiogênese na condição diabética,entretanto, poucos são os estudos que mostram a previsibilidade da cicatrização em cirurgias periodontais em pacientes com diabetes mellitus. O objetivo do estudo foi avaliar os mecanismos fisiopatológicos da cicatrização de feridas nos tecidos periodontais em diabéticos (AU)
Diabetes Mellitus is a systemic disorder that affects the production of insulin excreted by the pancreas and triggers to a host of events in the host's immune response, causing a change in the periodontal tissues. Periodontal disease is an inflammatory disorder that reaches the supporting tissues of the teeth and can be triggered by previously installed systemic disorders. A bidirectional link between Diabetes Mellitus and periodontal disease has been evidenced over the last years. Healing after dental treatment is impaired in diabetic patients. Diabetics have difficulty in healing, due to impaired immune response, due to compromised neutrophil response, fibroblast migration and proliferation, and angiogenesis in the diabetic condition. However, a few studies show the predictability of healing in periodontal surgeries in patients with diabetes mellitus. The aim of this study was to evaluate the pathophysiological mechanisms of the wound healing in periodontal tissues in diabetics (AU)
الموضوعات
Periodontal Diseases , Oxidative Stress , Diabetes Mellitusالملخص
A terapia periodontal de suporte (TPS) tem como objetivo principal a manutenção dos resultados obtidos durante o tratamento periodontal ativo, sendo a forma mais previsível de controlar a doença periodontal. Essa extensão do tratamento periodontal, pode ocorrer em intervalos de tempo que variam de acordo com a severidade da doença, condição sistêmica do indivíduo, idade, fatores de risco, entre outros. A TPS contribui para a redução da perda dentária e recorrência da doença periodontal, além de possibilitar o diagnóstico de outras doenças bucais. Durante essa etapa, é possível traçar o perfil do paciente, identificar suas dificuldades e estabelecer condutas educativas, preventivas e terapêuticas necessárias para o controle do biofilme e da doença periodontal. Assim, o periodontista deve conscientizar o paciente sobre a importância da TPS, sendo que, a adesão ao tratamento é fundamental para a manutenção da saúde dos tecidos periodontais a longo prazo. O presente relato de caso clínico, demonstra o sucesso da TPS em paciente jovem acometida por periodontite agressiva generalizada. Após a realização da terapia periodontal não cirúrgica, a paciente foi inserida em um programa de manutenção periodontal, há 13 anos atrás, no qual participa ativamente até o presente momento. (AU)
The main objective of the periodontal maintenance therapy (PMT) is to maintain the results achieved during the active periodontal therapy, being the most predictable way of controlling the periodontal disease. This extension of the periodontal treatment may occur at different times, varying according to the aggressiveness of the disease, general health condition of the subject, age and risk factors, among others. The PMT contributes to the reduction of dental loss and prevents the reoccurrence of the periodontal disease, while also allowing the diagnose of other diseases of the mouth. During this phase it is possible to trace the patient's profile, identifying the difficulties and stablishing educational, preventive and therapeutic practices to control oral biofilm and periodontal disease. Thus, the periodontist must raise the patient's awareness to the importance of the PMT, as the patient compliance to the treatment is essential for the long term preservation of the periodontal tissue health. The clinical case here described demonstrates the success of the PMT performed on a young female patient afflicted with generalized aggressive periodontitis. After having performed the non-surgical periodontal therapy, the patient entered a periodontal maintenance program 13 years ago, in which she has been actively participating until the present time.(AU)
الموضوعات
Humans , Female , Adult , Periodontal Diseases , Aggressive Periodontitis , Dental Scaling , Biofilmsالملخص
A saliva é um fluido biológico bucal secretado por glândulas salivares e tem grande participação na regulação da microbiota bucal. Atualmente diversas áreas da pesquisa científica adotam o uso da saliva na elaboração de diagnósticos e previsibilidade de terapias afins. Esta tendência se deve ao fato de que o uso da saliva é uma fonte rica de informações moleculares e sua aquisição é relativamente simples por ser uma técnica não invasiva, de fácil coleta, baixo custo, indolor e segura. A saliva pode ser usada no diagnóstico precoce de doenças sistêmicas (câncer, doenças infecciosas e cardiovasculares) e diversas substâncias orgânicas e inorgânicas podem ser detectadas, assim como drogas e seus metabólitos e marcadores biológicos. Particularmente em periodontia, o uso da saliva pode ser importante no diagnóstico, na quantificação de bactérias, na avaliação de interleucinas, nitrato e nitrito entre outros. Assim, o objetivo desta revisão de literatura é atualizar clínicos e periodontistas em relação a importância da saliva como uma ferramenta valiosa no diagnóstico e no monitoramento da condição do hospedeiro em relação às patologias periodontais.(AU)
Saliva is a buccal biological fluid secreted by salivary glands and has great participation in the regulation of the oral microbiota. Currently several areas of scientific research adopt the use of saliva in the elaboration of diagnoses and predictability of related therapies. This trend is due to the fact that the use of saliva is a rich source of molecular information and its acquisition is relatively simple because it is a noninvasive technique, easy to collect, low cost, painless and safe. Saliva can be used for the early diagnosis of systemic diseases (cancer, infectious and cardiovascular diseases) and various organic and inorganic substances can be detected, as well as drugs and their metabolites and biological markers. Particularly in periodontics, the use of saliva may be important in the diagnosis, in the quantification of bacteria, in the evaluation of interleukins, nitrate and nitrite among others. Thus, the objective of this literature review is to update clinicians and periodontists regarding the importance of saliva as a valuable tool in the diagnosis and monitoring of the host condition in relation to periodontal pathologies.(AU)
الموضوعات
Periodontal Diseases , Saliva , DNA , Diagnosisالملخص
Introduction: Adults with sequelae of periodontal disease tend to have bone loss, with consequent flaring of the maxillary incisors. Objective: The influence of bone loss and the inclination of the maxillary incisor in the distribution of stresses due to simulated bite forces was studied. Material and method: Models in epoxy resin were made in three conditions (without bone loss and with bone loss of 5mm and 8mm). Increases in the labial inclination of the maxillary incisor of 10° and 20° were obtained with a beveled metallic block. Loads of 100N were applied five times in each condition using a universal test machine. The models were observed and filmed with a circular polariscope. Orders of isochromatic fringes (stresses) on the labial, lingual, and apex surfaces were recorded. The agreement of the data was evaluated using the weighted kappa test, and the results were 0.89 and 0.82 for intra- and inter-examiners, respectively. Result: The results of the Kruskal-Wallis and SNK tests indicated higher stresses (2.0) with increased labial inclination in the labial surface; higher stresses (2.67) with increased bone loss; higher greater stresses with the association of bone loss and labial-inclination (3.6); and the highest stresses tended to concentrate on the labial surfaces, except in cases of normal inclination and without bone loss (0.45). Conclusion: It was concluded that increases in both the labial inclination of the maxillary incisors and bone loss increase periradicular stresses, and the combination of these factors further increases the stresses due to bite forces, with the highest concentration on the labial side.
Introdução: Adultos com sequelas de doenças periodontais tendem a apresentar perda óssea, com consequente vestibularização dos incisivos superiores. Objetivo: A influência da perda óssea e da inclinação do incisivo superior na distribuição de tensões devido a forças mastigatórias simuladas foram avaliadas nesse estudo. Material e método: Modelos em resina epóxi foram confeccionados em três condições (sem perda óssea e com perda óssea de 5mm e 8mm). Aumentos na inclinação vestibular do incisivo superior de 10° e 20° foram obtidos com um bloco metálico chanfrado. Cargas de 100N foram aplicadas cinco vezes em cada condição usando uma máquina de ensaio universal. Os modelos foram observados e filmados com um polariscópio circular. Ordens de franjas isocromáticas (tensões) nas faces vestibular, lingual e apical foram registradas. A concordância dos dados foi avaliada pelo teste kappa ponderado e os resultados foram 0,89 e 0,82 para intra e interexaminadores, respectivamente. Resultado: Os resultados dos testes de Kruskal-Wallis e SNK indicaram maiores tensões (2,0) com aumento da inclinação vestibular na face vestibular; maiores tensões (2,67) com aumento da perda óssea; maior tensão com a associação de perda óssea e inclinação vestibular (3,6); e as maiores tensões tenderam a concentrar-se na face vestibular, exceto em casos de inclinação normal e sem perda óssea (0,45). Conclusão: Concluiu-se que aumentos tanto da inclinação vestibular dos incisivos superiores quanto da perda óssea aumentam as tensões perirradiculares, e a combinação desses fatores aumenta ainda mais as tensões devido às forças mastigatórias, com a maior concentração na face vestibular.
الموضوعات
Periodontal Diseases , Bite Force , Alveolar Bone Loss , Statistics, Nonparametric , Dental Stress Analysis , Incisor , Bone Resorption , Epoxy Resinsالملخص
Introduction: Salivary components can be used as biomarkers for diagnosing and monitoring oral diseases. There is evidence that one potential biomarker, arginase, is associated with the inflammatory processes of periodontal disease, and its enzymatic activity is reduced according to the improvement in the clinical parameters after treatment. Objective: The present study aimed to evaluate the salivary arginase activity in gingivitis and periodontitis patients treated with full-mouth mechanical procedures combined with the adjunctive use of essential oils or chlorhexidine mouthwash, respectively. Material and method: Twenty-six gingivitis and 16 periodontitis patients received complete periodontal examinations at the baseline and 3 months after therapy, in which the periodontal probing depth, clinical attachment loss, plaque index, and gingival index measurements were taken. At these same appointments, the salivary total protein level and salivary arginase activity were also established via spectrophotometry. Result: There were improvements in all of the clinical parameters (p < 0.05) evaluated from the baseline to 3 months in both groups. In addition, the salivary arginase activity and total protein levels were reduced after the gingivitis treatment. Conclusion: Similar to the clinical results, both therapeutic protocols positively affected the salivary arginase activity; however, further studies are necessary to clarify its potential as a salivary biomarker for periodontal monitoring.
Introdução: Componentes salivares podem ser usados como biomarcadores para diagnóstico e monitoramento de doenças orais. Há evidências de que um potencial biomarcador, arginase, está associado com os processos inflamatórios da doença periodontal, e após o tratamento sua atividade enzimática é reduzida em concordância com a melhora nos parâmetros clínicos. Objetivo: O presente estudo objetivou avaliar a atividade da arginase salivar em pacientes com gengivite e periodontite tratados com procedimentos mecânicos em estágio único combinados ao uso coadjuvante de enxaguatórios com óleos essenciais ou clorexidina, respectivamente. Material e método: Vinte e seis pacientes com gengivite e 16 pacientes com periodontite receberam exame periodontal completo antes e 3 meses após a terapia, em que mensurações de profundidade de sondagem, perda de inserção clínica, índice de placa e índice gengival foram realizadas. Nestas mesmas consultas os níveis de proteína total e a atividade de arginase salivar foram estabelecidos via espectrofotometria. Resultado: Todos os parâmetros clínicos melhoraram, em ambos os grupos, do exame inicial para o de 3 meses (p < 0,05). Adicionalmente, após tratamento para gengivite houve redução da atividade de arginase salivar e do nível de proteína total. Conclusão: Semelhante aos resultados clínicos, ambos os protocolos terapêuticos afetaram positivamente a atividade da arginase salivar; entretanto, estudos futuros são necessários para clarificar seu potencial como biomarcador salivar para o monitoramento periodontal.
الموضوعات
Humans , Periodontitis , Arginase , Saliva , Oils, Volatile , Chlorhexidine , Diagnosis , Gingivitis , Periodontal Diseases , Biomarkers , Mouth Diseasesالملخص
Abstract In the search for the ideal treatment of periodontal disease various non-surgical techniques should be considered. The objective of this study was to evaluate the efficacy of full-mouth scaling (FMS) by clinical and microbiological parameters. 670 individuals were evaluated with 230 subjects meeting the selection criteria and were divided into two groups; 115 subjects treated with FMS and 115 treated with weekly sessions of scaling and root planning (SRP). The patient population had a mean age of 51.67 years, with moderate chronic periodontitis. Subjects were evaluated prior to treatment (T1) and 90 days after execution of therapy (T2), with regards to: probing depth (PD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and microbial detection for the presence of Porphyromonas gingivalis (P.g.) and Prevotella intermedia (P.i.) by culture method and confirmed by biochemical tests. Subjects treated in the FMS group also rinsed with 0.12% chlorhexidine mouthwash for seven days following treatment. The results were analyzed using statistical Student's t-test and chi-square test. No statistically significant differences were observed for PD and CAL between T1 and T2 in both groups. For GI and PI significant difference was observed between the groups. For the evaluated microbial parameters was observed reduction of P.g. and P.i., but only for P.g. with a significant reduction in both groups. The full mouth scaling technique with the methodology used in this study provided improved clinical conditions and reduction of P.g. in subjects with moderate periodontitis, optimizing the time spent in the therapeutic execution.
Resumo Na busca do tratamento ideal da doença periodontal varias são técnicas não-cirúrgicas que podem ser consideradas. O objetivo deste estudo foi avaliar a eficácia da técnica de desinfecção total de boca (FMD, na sigla em Inglês) por parâmetros clínicos e microbiológicos. Foram avaliados 670 indivíduos com 230 indivíduos atendendo aos critérios de seleção e divididos em dois grupos; 115 indivíduos tratados com FMD e 115 tratados com sessões semanais de raspagem e alisamento corono radicular (SRP, na sigla em Inglês). A população avaliada tinha idade média de 51,67 anos, com periodontite crônica moderada. Os sujeitos foram avaliados antes do tratamento (T1) e 90 dias após a execução da terapia (T2), quanto à profundidade de sondagem (PS), nível de inserção clínica (NIC), índice de placa (IP), índice gengival (IG) e detecção microbiana da presença de Porphyromonas gingivalis (P.g.) e Prevotella intermedia (P.i.) por método de cultura e confirmada por testes bioquímicos. Os indivíduos tratados no grupo FMD também realizaram bochechos com clorexidina 0,12% durante sete dias após o tratamento. Os resultados foram analisados utilizando o teste estatístico t de Student e o teste de qui-quadrado. Não foram observadas diferenças estatisticamente significativas para PS e NIC entre T1 e T2 em ambos os grupos. Para IG e IP observou-se diferença significativa entre os grupos. Para os parâmetros microbianos avaliados foi observada redução de P.g. e P.i., mas apenas para P.g. com uma redução significativa em ambos os grupos. A técnica FMD com a metodologia utilizada neste estudo proporcionou condições clínicas melhoradas e redução da P.g. Em indivíduos com periodontite moderada, otimizando o tempo gasto na execução terapêutica.
الموضوعات
Humans , Male , Female , Adult , Middle Aged , Dental Scaling/methods , Chronic Periodontitis/therapy , Periodontal Pocket/therapy , Chlorhexidine/therapeutic use , Periodontal Index , Dental Plaque Index , Longitudinal Studies , Root Planing/methods , Periodontal Attachment Loss/therapy , Porphyromonas gingivalis/isolation & purification , Prevotella intermedia/isolation & purification , Dental Plaque/microbiology , Disinfectants/therapeutic use , Chronic Periodontitis/microbiology , Mouthwashes/therapeutic useالملخص
A proposta desta revisão da literatura foi avaliar as técnicas empregadas no afastamento gengival para prótese dental incluindo métodos mecânicos, químicos-mecânicos e cirúrgicos. A técnica de afastamento gengival deve ser previamente avaliada pelo profissional e a sua indicação, dependerá de cada situação clínica. Nesta revisão foram apresentadas as vantagens e desvantagens das técnicas de afastamento gengival incluindo fio afastador embebido ou não em soluções químicas, técnicas cirúrgicas, procedimentos a base de laser, curetagem gengival e eletro cirurgia. Após a realização desta revisão verificamos que o método químico-mecânico é o mais utilizado pelos profissionais. Atualmente podemos considerar que mesmo com a utilização de tecnologias mais elaboradas, como por exemplo scanners intraorais, quando o término do preparo dental estiver ao nível gengival ou subgengival se faz necessário o afastamento gengival. Para atingir o sucesso de uma prótese dental e importante coexistir uma harmonia entre a prótese e os tecidos periodontais circunvizinhos. (AU)
The aim of this review was to assess the use of gingival retraction methods in the fixed tooth supported prosthesis including mechanical, chemicals-mechanical and surgical methods. The choice of the best gingival retraction technique should be considered previously by the professional and it depends of each individual clinical conditions. In this review were discussed the advantages and the disadvantages of each gingival retraction technique including mechanical, chemical and surgical methods. In this review, we could understand that chemicals-mechanical technical is the most indicate by dentists. Nowadays, we can consider that even with the hightech use in dental area, such as intraoral scanners, when the margin of the restoration is placed sub-gingivally the gingival retraction should be considered. For the successful in dental prosthesis, a healthy coexistence between the restoration and their surrounding periodontal structure should be the goal of a prosthodontist. (AU)
الموضوعات
Subgingival Curettage , Oral Health , Crown Lengthening , Dental Prosthesis , Gingivaالملخص
O aspecto retentivo dos braquetes promove alterações na microbiota bucal podendo causar danos, às vezes irreversíveis, ao periodonto de sustentação. Há uma controvérsia quanto à associação do desenho dos braquetes com o aumento quantitativo e as alterações qualitativas no microbioma periodontal. Braquetes autoligados supostamente acumulariam menor quantidade de biofilme que os braquetes convencionais devido à ausência das ligaduras elásticas. Mas, existem outras variáveis que intercedem na retenção do biofilme. Assim, o presente estudo teve como objetivo revisar a literatura sobre as alterações microbiológicas que se associam ao uso de braquetes convencionais ou autoligados. A literatura analisada mostrou que para entender o perfil microbiológico e suas alterações deve-se além de comparar o desenho dos braquetes, considerar o tipo de material, a retentividade dos sítios onde os braquetes estão instalados e o padrão de higiene bucal. Ainda não está claro se as alterações microbiológicas observadas se restringem ao período de tratamento ortodôntico ativo ou se elas permanecem mesmo após a remoção dos braquetes. É possivel concluir que a presença de braquetes ortodônticos aumenta a quantidade de biofilme e induz alterações da microbiota, que podem, em alguns casos, serem apenas transitórias. Porém ainda não está claro quais são as reais diferenças entre braquetes convecionais e autoligados no que se refere à colonização microbiana. (AU)
The retentive bracket design promotes changes in the oral microbiome and it can cause damage, sometimes irreversible, to periodontal supportive tissues. The association between bracket design with qualitative changes and quantitative bacterial increase in periodontal microbiome is controversial. Self-ligating brackets would supposedly accumulate less biofilm then conventional brackets due to the absence of elastic ligature. However, other variables could influence biofilm retention. Thus, the present study aimed at reviewing the literature on microbiological changes associated with the use of conventional or self - ligating brackets. The analyzed literature showed that the understandingregarding microbiological profile and related changesrequires evaluation of material type, retentive nature of sites where the brackets are installed, oral hygiene pattern in adittion to bracket design. It is not clear if observed microbiological changes are restricted to the period of active orthodontic treatment or if they remain even after bracketsremoval. It is possible to conclude that the presence of orthodontic brackets increases the amount of biofilm and promotes changes in microbiome, which may in some cases be only transitory. However, it is still not clear what are the real differences between conventional and selfligating brackets regarding microbial colonization. (AU)
الموضوعات
Orthodontic Appliances , Periodontal Diseases , Bacteria , Orthodontic Bracketsالملخص
Abstract Objective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. Material and Methods: Systemically healthy individuals with gingivitis (n=27) or periodontitis (n = 27) were randomly allocated through a sealed envelope system to: 0.12% chlorhexidine pre-procedural rinse (13 gingivitis and 13 periodontitis patients) or no rinse before dental scaling (14 gingivitis and 15 periodontitis patients). Periodontal probing depth, clinical attachment level, plaque, and gingival indices were measured and subgingival samples were collected. Blood samples were collected before dental scaling, 2 and 6 minutes after scaling. Total bacterial load and levels of P. gingivalis were determined in oral and blood samples by real-time polymerase chain reaction, while aerobic and anaerobic counts were determined by culture in blood samples. The primary outcome was the antimicrobial effect of the pre-procedural rinse. Data was compared by Mann-Whitney and Signal tests (p<0.05). Results: In all sampling times, polymerase chain reaction revealed higher blood bacterial levels than culture (p<0.0001), while gingivitis patients presented lower bacterial levels in blood than periodontitis patients (p<0.0001). Individuals who experienced bacteremia showed worse mean clinical attachment level (3.4 mm vs. 1.1 mm) and more subgingival bacteria (p<0.005). The pre-procedural rinse did not reduce induced bacteremia. Conclusions: Bacteremia was influenced by periodontal parameters. In periodontally diseased patients, pre-procedural rinsing showed a discrete effect on bacteremia control.
الموضوعات
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Periodontitis/drug therapy , Chlorhexidine/administration & dosage , Dental Scaling , Bacteremia/prevention & control , Gingivitis/drug therapy , Mouthwashes/administration & dosage , Periodontitis/microbiology , Severity of Illness Index , Bacteremia/drug therapy , Real-Time Polymerase Chain Reactionالملخص
A determinação ou pressuposição da vitalidade pulpar assume no dia-a-dia papel de capital importância no diagnóstico clínico com vistas à indicação ou não da terapia endodôntica. O objetivo do presente estudo foi avaliar a eficiência clínica de dois recursos térmicos, a saber: o bastão de gelo e o gás refrigerante, na deter¬minação da vitalidade pulpar em dentes humanos antes e após a realização de terapia periodontal, incluindo raspagem e aplainamento radicular e/ou procedimentos cirúrgicos periodontais. Para tanto, foram incluídos 60 pacientes de ambos os sexos e faixa etária entre 21 a 64 anos de idade num total de 411 dentes indica¬dos à terapia periodontal e analisados em dois tempos, a saber, na condição pré e pós-terapia periodontal. Realizaram-se o exame do paciente e o exame radiográfico periapical. Foi feita a aplicação dos dois agentes térmicos, o bastão de gelo e gás refrigerante, para obtenção da resposta dolorosa pulpar antes dos procedimen¬tos periodontais. Após uma semana os pacientes retornaram para nova aplicação dos testes de sensibilidade pulpar, valendo-se dos mesmos procedimentos de testes que foram executados na primeira sessão de exame do paciente. Para saber se houve diferença significativa entre as proporções, utilizou-se o teste não paramétrico Qui-quadrado (c2) em nível de 95% de confiança. Concluiu-se que ocorreu um número maior de respostas positivas após os procedimentos periodontais para os dois testes, exceção notada no dente pré-molar (p>0,05), indicando que não existe diferença na frequência de respostas positivas e negativas tanto antes como após a terapia periodontal
The determination or presumption of pulp vitality assumes a central role in clinical diagnosis for the indica¬tion of endodontic therapy or not. The aim of this study was to evaluate the clinical efficiency of two thermal resources: the ice stick and the refrigerant gas in determining pulp vitality in teeth before and after periodontal therapy including scaling and root planning and/or periodontal surgical procedures. For this, 60 patients of both genders and age between 21 and 64 years old were included. A total of 411 teeth indicated for periodontal therapy were analyzed in two times, namely in the pre and post periodontal therapy condition. The patient's examination and periapical radiographic examination were performed. The two thermal agents were applied to obtain the pulpal pain response before the periodontal procedures. After one week, the patients returned to a new application of the pulp sensitivity tests using the same test procedures that were performed in the first patient examination session. To determine if there was a significant difference among the proportions, the non-parametric Chi-square test was used at a 95% confidence level. It was concluded that there was a higher num¬ber of positive responses after the periodontal procedures for the two tests, exceptions noted in the premolar tooth (p> 0.05), indicating that there is no difference in the frequency of positive and negative responses both before and after periodontal therapy
الموضوعات
Humans , Male , Female , Adult , Middle Aged , Dental Pulp Test , Periodontics , Cold Temperatureالملخص
Abstract Periodontitis can contribute to the development of insulin resistance. Gestational diabetes is a risk factor for type 2 diabetes. Therefore, periodontitis, when associated with gestational diabetes, could increase the risk for the development of type 2 diabetes after pregnancy. Objective The aim of this study was to verify the incidence on the development of type 2 diabetes in women with previous gestational diabetes with and without periodontitis after a three-year time interval. Material and Methods Initial sample of this follow-up study consisted of 90 women diagnosed with gestational diabetes who underwent periodontal examination. After three years, 49 women were subjected to new periodontal examination and biological, behavioral, and social data of interest were collected. Additionally, the quantification of the C-reactive protein in blood samples was performed. Fasting glucose and glycated hemoglobin levels were requested. Saliva samples were collected for quantification of interleukin 6 and 10, tumor necrosis factor α, matrix metalloproteinase 2 and 9. Results The incidence of type 2 diabetes mellitus was 18.4% and of periodontitis was 10.2%. There was no significant difference in the incidence of type 2 diabetes mellitus among women with and without periodontitis. It was observed impact of C-reactive protein in the development of type 2 diabetes mellitus. However, it was not observed impact of periodontitis on the development of type 2 diabetes mellitus among women with previous gestational diabetes. Conclusions It was not observed impact of periodontitis on the development of type 2 diabetes among women with previous gestational diabetes. The impact of C-reactive protein in the development of type 2 diabetes mellitus highlights the importance of an inflammatory process in the diabetes pathogenesis.
الموضوعات
Humans , Female , Pregnancy , Adult , Periodontitis/epidemiology , Diabetes, Gestational/epidemiology , Diabetes Mellitus, Type 2/epidemiology , Periodontitis/complications , Periodontitis/metabolism , Reference Values , Saliva/chemistry , Time Factors , Blood Glucose/analysis , Brazil/epidemiology , C-Reactive Protein/analysis , Glycated Hemoglobin/analysis , Epidemiologic Methods , Risk Factors , Interleukin-6/analysis , Tumor Necrosis Factor-alpha/analysis , Interleukin-10/analysis , Diabetes, Gestational/metabolism , Matrix Metalloproteinase 2/analysis , Matrix Metalloproteinase 9/analysis , Diabetes Mellitus, Type 2/etiology , Diabetes Mellitus, Type 2/metabolismالملخص
ABSTRACT Objectives This cross-sectional study compared the frequency of oral periodontopathogens and H. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. Material and Methods One hundred and fifty-four men and women aged 18-65 were conveniently distributed into four groups. Two groups were composed of individuals who underwent bariatric surgery with (BP) (n=40) and without (BNP) (n=39) periodontitis and two obese control groups with (CP) (n=35) and without (CNP) (n=40) periodontitis. The oral pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Parvimonas micra, Treponema denticola, Tannerella forsythia, Campylobacter rectus, and Helicobacter pylori were detected by a polymerase chain reaction technique using saliva, tongue and stomach biopsy samples. Results Statistical analysis demonstrated that periodontopathogens were highly frequent in the mouth (up to 91.4%). In the bariatric surgically treated group, orally, P. gingivalis, T. denticola and T. forsythia were more frequent in periodontitis, while C. rectus was more frequent in non-periodontitis subjects. Stomach biopsies also revealed the high frequency of five oral species in both candidates for bariatric surgery (91.6%) and the bariatric (83.3%) groups. H. pylori was frequently detected in the mouth (50.0%) and stomach (83.3%). In the stomach, oral species and H. pylori appeared in lower frequency in the bariatric group. Conclusions Obese individuals showed high frequencies of periodontopathogens and H. pylori in their mouths and stomachs. Bariatric surgery showed an inverse microbial effect on oral and stomach environments by revealing higher oral and lower stomach bacterial frequencies.
الموضوعات
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Young Adult , Stomach/microbiology , Bacteria/isolation & purification , Helicobacter pylori/isolation & purification , Bariatric Surgery , Mouth/microbiology , Obesity/microbiology , Periodontitis/microbiology , Reference Values , Saliva/microbiology , Biopsy , Body Mass Index , Periodontal Index , Polymerase Chain Reaction , Cross-Sectional Studies , Analysis of Variance , Statistics, Nonparametric , Dental Plaque/microbiology , Obesity/surgeryالملخص
O objetivo deste estudo foi avaliar, por meio de ensaio clínico controlado randomizado, a efetividade da técnica one stage full mouth disinfection (FMD) e sua associação com clorexidina ou azitromicina em relação à raspagem e alisamento radicular por quadrante (RAR) associada à clorexidina e azitromicina sob uma perspectiva clínica (avaliação da profundidade de sondagem e nível clínico de inserção). Neste ensaio clínico controlado randomizado foram avaliados 77 indivíduos divididos em 6 grupos: FMD-CX (raspagem e alisamento radicular de todos os dentes em 24 h associada à clorexidina n= 15), FMD (raspagem e alisamento radicular de todos os dentes em 24 h n=10), FMD-AZ (raspagem e alisamento radicular de todos os dentes em 24 h + azitromicina n=15), RAR-AZ (raspagem e alisamento radicular por quadrante em intervalos semanais + azitromicina n=11), RAR-CX (raspagem e alisamento radicular por quadrante, em intervalos semanais + clorexidina n=13), RAR (raspagem e alisamento radicular, por quadrantes, em intervalos semanais n=13). Os parâmetros clínicos foram analisados estatisticamente pelo teste de análise de variância (ANOVA) baseado em um planejamento para medidas repetidas e teste de comparações múltiplas de médias. O grupo FMD-CX mostrou maior redução da profundidade de sondagem e ganho do nível clínico de inserção que os demais. Os grupos que utilizaram azitromicina não mostraram melhores resultados clínicos. Pode-se concluir que a utilização da clorexidina nos grupos FMD-CX e RAR-CX mostrou melhores resultados clínicos. Por outro lado, a utilização da azitromicina não apresentou melhorias nesses parâmetros.
The aim of this study was to evaluate, through randomized controlled clinical trial, the effectiveness of the technique one stage full mouth disinfection (FMD) and its association with chlorhexidine or azithromycin compared to scaling and root planing per quadrant (RAR) associated with chlorhexidine and azithromycin under a clinical perspective (assessment of probing depth and clinical attachment level). In this randomized controlled trial were evaluated 77 patients divided into 6 groups: FMD-CX (scaling and root planing of all teeth in 24 h associated with chlorhexidine n = 15), FMD (scaling and root planing of all teeth in 24 h - n = 10), FMD-AZ (scaling and root planing of all teeth in 24 h + azithromycin - n = 15), RAR-AZ (scaling and root planing per quadrant at weekly intervals azithromycin + - n = 11), RAR-CX (scaling and root planing per quadrant, at weekly intervals chlorhexidine + - n = 13), RAR (scaling and root planing, per quadrant, at weekly intervals - n = 13). The clinical parameters were statistically analyzed by analysis of variance (ANOVA) based on a planning for repeated measures and multiple comparisons of means test. The FMD-CX group showed greater reduction in probing depth and gain in clinical attachment level than the others. Groups using azithromycin did not show improved clinical outcomes. It can be conclude that the use of chlorhexidine groups FMD-CX and CX-RAR showed the best clinical results. On the other hand, the use of azithromycin in these parameters showed no improvement.
الموضوعات
Humans , Male , Female , Middle Aged , Young Adult , Azithromycin , Chlorhexidine , Periodontitis , Dental Scalingالملخص
Background: Several studies have investigated the differences in salivary parameters and microbial composition between diabetic and non-diabetic patients, however, specific differences are still not clear mainly due to the effects of confounder. Aim: The aim of this case-control study was to evaluate the salivary and microbial parameters of chronic periodontitis subjects with and without type 2 diabetes mellitus. Material and method: This case-control study included 60 chronic periodontitis subjects, 30 diabetics (case group) and 30 non-diabetics (control group), paired according to periodontitis severity, gender and age. Stimulated whole saliva was collected from all volunteers to measure the salivary pH and the salivary flow rate. Bacterial samples were collected with paper points from periodontal sites showing the deepest periodontal pocket depth associated with the highest clinical attachment loss. The frequency of A. actinomycetemcomitans, P. intermedia, P. gingivalis, T. forsythia and C. rectus was evaluated by PCR. Data was statistically analyzed by Student's t, Mann-Whitney and Chi-square (p<0.05). Result: Diabetic subjects showed higher salivary glucose levels and lower stimulated flow rates in comparison to non-diabetic controls. P. gingivalis and T. forsythia were the most frequent pathogens (p<0.05). Bacterial frequency did not differ between case and control groups. Conclusion: Diabetes status influenced salivary glucose levels and flow rate. Within the same severity of chronic periodontitis, diabetic subjects did not show higher frequency of periodontal pathogens in comparison to their paired controls. .
Introdução : Diversos estudos têm investigado as diferenças dos parâmetros salivares e microbianos entre pacientes diabéticos e não diabéticos, contudo, diferenças específicas ainda não estão claras, principalmente devido aos efeitos de variáveis de confusão. Objetivo: O objetivo deste estudo caso-controle foi avaliar os parâmetros salivares e microbianos de indivíduos com doença periodontal crônica com ou sem diagnóstico de diabetes melito tipo 2. Material e método: Este estudo caso-controle incluiu 60 indivíduos com periodontite crônica, 30 diabéticos (casos) e 30 não diabéticos (controles), pareados pela severidade da doença periodontal, gênero e idade. Saliva total estimulada foi coletada de todos os voluntários para mensuração do pH salivar e fluxo salivar. Amostras bacterianas foram coletadas com pontas de papel absorvente dos sítios periodontais com maior profundidade de sondagem e perda de inserção clínica. A frequência de A. actinomycetemcomitans, P. intermedia, P. gingivalis, T. forsythia e C. rectus foi avaliada por PCR. Os dados foram analisados estatisticamente pelo teste t de Student, Mann -Whitney e Qui-quadrado (p < 0,05). Resultado: Diabéticos apresentaram maior nível de glicose salivar e menor fluxo salivar em comparação aos não diabéticos. P. gingivalis e T. forsythia foram os patógenos mais frequentes (p < 0,05). Frequência bacteriana não diferiu entre os casos e controles. Conclusão: A condição diabetes influenciou o fluxo e os níveis de glicose salivar. Dentro da mesma severidade da periodontite crônica, indivíduos diabéticos não mostraram maior frequência de patógenos periodontais em comparação aos seus controles. .
الموضوعات
Saliva , Bacteria , Chi-Square Distribution , Statistics, Nonparametric , Diabetes Mellitus, Type 2 , Chronic Periodontitisالملخص
Apesar do efeito placebo já representar um fenômeno reconhecido em medicina e pesquisa seu mecanismo de ação até agora ainda não foram completamente entendidos. O efeito placebo é o resultado da administração de uma substância que não apresente efeito farmacológico sobre o problema a ser tratado, mas com uma aparência similar ao agente ativo que está sendo comparado. O efeito placebo é mais eficaz do que o não tratamento em estudos clínicos. Na medicina, diversos investigadores perceberam que seria importante obter uma maior compreensão do efeito placebo nos estudos clínicos. Apesar do maior interesse quando da incorporação de placebos nos estudo clínicos, o entendimento da resposta placebo parece ser fundamental. Esta revisão da literatura abordou alguns mecanismos do uso de placebo e suas implicações na prática clínica. Observamos que progressos estão sendo feitos principalmente em medicina, mas verificamos que em odontologia estes estudos ainda são raros.
Although placebo effect is a common phenomenon in medicine and research, its mechanism so far are not well understood. The placebo effect is the result of administration of a substance with no pharmacological effect on the problem to be treated, but with a similar appearance to the active product to which it is being compared, and is seen to be more efficacious than an untreated control group. In medicine many researchers have realized that much could be gained by a better understanding of placebo effects and, therefore, have taken a keen interest in this area. Despite improvements in the placebo groups are commonly observed in randomized clinical trial it seem important to identify the mechanism under lying these placebo responses. In this article, we review some theories on placebo mechanisms and their implications for clinical practice. We concluded that considerable progress has been made in understanding placebo effects in medicine, however, we noted that there has been relatively little studies of the scope of placebo phenomena in Dentistry then only scarce knowledge relate placebo is available in this field.
الموضوعات
Placebo Effect , Placebosالملخص
O objetivo deste ensaio clínico randomizado de 3 meses de duração foi avaliar os efeitos da combinação de procedimentos mecânicos e químicos sobre os níveis de sangramento gengival, Compostos Sulfurados Voláteis (CSV) e carga total bacteriana de pacientes com gengivite. Sessenta voluntários sistemicamente saudáveis com gengivite foram divididos em dois grupos: raspagem profissional associada ao uso diário de óleos essenciais (20ml/2x/dia) ou solução placebo (20ml/2x/dia). Todos os participantes receberam instruções de higiene bucal. Índice de sangramento gengival, carga bacteriana total subgengival (PCR em tempo real) e concentrações de CSV (dosador portátil Halimeter) foram mensurados antes e 90 dias após o tratamento gengival. Os dados foram comparados estatisticamente pelos teste t-Student e teste t-pareado (p < 0,05). Resultados: Finalizaram o estudo 27 indivíduos no grupo teste e 25 no grupo placebo. A carga bacteriana total e o IG reduziram mais evidentemente no grupo teste do que no grupo placebo. No grupo teste os valores médios de CSV reduziram de 94,62ppb (inicial) para 62,19ppb (3 meses) enquanto no grupo placebo eles se mantiveram estáveis entre as mensurações inicial (93,46ppb) e de 3 meses (95,00ppb). Conclusões: o tratamento gengival seguido de 90 dias de uso de solução de óleos essenciais acarretou melhora dos parâmetros monitorados, IG, carga total bacteriana e CSV.
The aim of this 3-month randomized clinical study was to evaluate the effects of the combination of mechanical and chemical procedures over the levels of gingival bleeding, VSC and total bacterial load in patients with gingivitis. Sixty systemically healthy individuals with gingivitis were randomized in two groups: professional debridement along with the daily use of essential oils (20ml/2x/day) or of a placebo solution (20ml/2x/day). All participants received oral hygiene instructions. Gingival Index, total bacterial load (real time PCR) and VSC concentration (portable Halimeter) were measured at baseline and at 90 days after gingival treatment. Data were statistically compared by Student-t test and paired-t test (p < 0.05). Results: Twenty-seven individuals finished the study in the test group and 25 in the placebo group. Total bacterial load and GI were greatest reduced in the test group than in the placebo group. Mean VSC values in the test group were reduced from 94,62ppb (at baseline) to 62,19ppb (3 months) while in the placebo group measures continued stable between baseline (93,46ppb) and (95,00ppb) 3-month examinations. Conclusions: Gingival treatment followed by the use of essential oils for 90 days lead to an improvement in the monitored parameters, GI, total bacterial load and VSC.