الملخص
Another additional peculiarity in Leishmania will be discussed about of the amino acid divergence rate of three structural proteins: acidic ribosomal P1 and P2b proteins, and histone H3 by using multiple sequence alignment and dendrograms. These structural proteins present a high rate of divergence regarding to their homologous protein in Trypanosoma cruzi. At this regard, L. (V.) peruviana P1 and T. cruzi P1 showed 57.4 per cent of divergence rate. Likewise, L. (V.) braziliensis histone H3 and acidic ribosomal P2 protein exhibited 31.8 per cent and 41.7 per cent respectively of rate of divergence in comparison with their homologous in T. cruzi.
الموضوعات
Animals , Histones/analysis , Leishmania/chemistry , Protozoan Proteins/analysis , Ribosomal Proteins/analysis , Amino Acid Sequence , Amino Acids/analysis , Leishmania/genetics , Phylogenyالملخص
El potencial diagnóstico de epitopes inmunodominantes seleccionados fue ensayado satisfactoriamente a fin de obtener una prueba serodiagnóstica alternativa para la Leishmaniasis Tegumentaria Americana. Dos proteínas recombinantes prometedoras de L. (v.) peruviana referidas como T-26-U2/T26-U4 fueron reconocidas por sueros individuales de pacientes con Leishmaniasis Tegumentaria Americana usuando Western Blot. La sensibilidad de la prueba fue de 86 con sueros permanetes con Leishmaniasis peruana