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1.
Rev. méd. Chile ; 137(6): 807-810, jun. 2009. ilus
مقالة ي الأسبانية | LILACS | ID: lil-524961

الملخص

Primary central nervous system vaculitis is an uncommon and invalidating disease, which has a fatal course if left untreated. We report a 63 year-old woman presenting with a history of two months of cognitive impairment, dysarthria, gait instability and tremor. After four months of evolution a right hemianopsia and a flaccid paresis of upper right limb appeared. A brain biopsy was performed and the histological findings confirmed the suspicion of primary cerebral vasculitis. The patient was treated with cyclophosphamide and prednisone, observing a partial recovery of cognitive and motor function.


الموضوعات
Female , Humans , Middle Aged , Vasculitis, Central Nervous System/pathology , Brain/pathology
2.
Rev. méd. Chile ; 134(8): 1010-1018, ago. 2006. ilus, tab
مقالة ي الأسبانية, الانجليزية | LILACS | ID: lil-438372

الملخص

Background: The spastic paraparesis associated to HTLV-1 causes degenerative pyramidal tract lesions of the spinal cord and affects cortical-nuclear connections in the brain. Aim: To report the findings of magnetic resonance imaging in patients with spastic paraparesis. Material and methods: A magnetic resonance imaging of the brain and spinal cord was performed in 30 patients (24 females), mean age and evolution of 56 and 12 years respectively, with a clinical and virological diagnosis of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). Results: No patient had abnormal signals in the spinal cord parenchyma. However, an atrophy of the dorsal segment was observed in 87 percent of patients. Patients with the highest degree of atrophy showed a higher degree of functional impairment. Eleven patients had spinal cord conus atrophy, associated to neurogenic bladder or impotency. In 80 percent of patients, hyperintense subcortical white matter images in DP, T2 and Flair, mostly bi frontal, were detected. In half of them, small rounded and isolated images were observed. In the other half, eight or more images, generally larger and occasionally confluent, were found. Ten of 12 patients with confluent brain lesions showed different degrees of cognitive impairment. No patient had lesions in the corpus callosus, periventricular white matter, pons, medulla oblongata or cerebellum. Conclusions: Most patients with tropical spastic paraparesis have alterations in brain or spinal cord magnetic resonance imaging. The magnetic resonance lesions are concordant with functional impairment. The characteristics of the imaging in TSP/HAM patients can be helpful in the differential diagnosis of patients with paraparesis.


الموضوعات
Adult , Aged , Female , Humans , Male , Middle Aged , Brain/pathology , HTLV-I Infections/pathology , Human T-lymphotropic virus 1 , Magnetic Resonance Imaging , Paraparesis, Tropical Spastic/pathology , Spinal Cord/pathology , Atrophy , Brain/virology , Diagnosis, Differential , HTLV-I Infections/virology , Paraparesis, Tropical Spastic/virology , Spinal Cord/virology
3.
Rev. méd. Chile ; 126(8): 981-6, ago. 1998. ilus
مقالة ي الأسبانية | LILACS | ID: lil-232944

الملخص

Optic neuromyelitis is characterized by simultaneous or successive necrotizing lesions involving the optic nerves and the spinal cord. We report two females with the disease, aged 30 and 34 years old. In the latter, a neuropathological study was done. Both patients had clinical, neuroradiological and pathological features that differed from those of primary demyelinating syndromes such as multiple sclerosis. These patients illustrate the selectivity of optic nerve and spinal cord lesions. The latter involve mainly pyramidal and Goll tracts while, within the necrotizing lesions of the optic chiasma, the fibers of the unaffected optic nerve are spared. This pattern suggests a selective injury to some population of axons. Blood vessels were not affected in the necrotizing areas and the lesions did not follow a vascular territory, therefore a vascular mechanism causing the disease is unlikely. The clinical and neuropathological features of neuromyelitis optic suggest a selective involvement of some axons


الموضوعات
Humans , Female , Adult , Neuromyelitis Optica/physiopathology , Necrosis , Ependyma/pathology , Optic Nerve/pathology
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