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ObjectiveTo analyze the current status, hotspots and trends of researches related to non-invasive brain stimulation for Parkinson's disease in the last decade. MethodsLiterature related to non-invasive brain stimulation for Parkinson's disease in the Web of Science Core Collection was searched from January, 2014, to December, 2023, and CiteSpace 6.1.R3 was used to draw a knowledge map of authors, institutions, countries and keywords. ResultsA total of 1 351 papers were included, with a general upward trend in the number of publication, with the United States, Italy and China being the high-producing countries, and the University of London being the most prolific institution, with Alfredo Berardelli being the most prolific author. Hot keywords included deep brain stimulation, motor cortex and basal ganglia, and emergent words that have appeared in the last two years included therapy, non-invasive brain stimulation, supplementary motor areas and movement disorders. ConclusionThe research hotspots related to non-invasive brain stimulation for Parkinson's disease in the last decade mainly focus on the stimulation on motor cortical areas, the combined application of non-invasive brain stimulation and deep brain stimulation, and non-invasive brain stimulation and non-invasive neuroimaging techniques, such as electroencephalography and functional imaging. Non-invasive brain stimulation of supplementary motor areas can be further explored to improve movement disorders in Parkinson's disease patients in the future.
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Objective:To explore the factors influencing the pulmonary function of persons with mild to moderate adolescent idiopathic scoliosis (AIS).Methods:Forty-four persons with AIS were tested for their pulmonary ventilation functioning. The indicators were the percentage of forced vital capacity (FVC%), the percentage of forced expiratory volume in the first second (FEV1%) and the percentage of maximum chase volume (MVV%). Data including age, gender, course of disease, dancing habits, exercise habits, body mass index (BMI), Cobb angle, rotation angle, diaphragm thickness, and diaphragm excursion (DE) were also collected. Linear regressions were evaluated to analyze the factors best predicting pulmonary functioning. Spearman correlation coefficients were computed to quantify the correlation between respiratory muscle functioning and pulmonary functioning.Results:The univariate analysis showed that dancing and DE independently influence FVC%, FEV1%, and MVV%. DE was the only independent factor significantly predicting pulmonary functioning for mild to moderate AIS patients. DE was also significantly positively correlated with average FVC%, FEV1% and MVV%.Conclusions:Respiratory training aimed at enhancing DE is necessary to improve the pulmonary ventilation of persons with AIS.
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Objective:To explore the effect of combining inspiratory muscle training with diaphragm resistance training on the respiratory, motor and balance functioning of stroke survivors.Methods:Eighty-eight stroke survivors were randomly divided into a respiratory muscle training group and a control group, each of 44. Both groups received routine rehabilitation, but the respiratory muscle training group also received daily inspiratory muscle and diaphragm resistance training, five days a week for 4 weeks. The respiratory muscle strength, motor function and balance of the two groups were evaluated using the inspiratory muscle strength index, the Fugl-Meyer assessment scale and the Berg balance scale before and after the treatment.Results:After the treatment, the average inspiratory muscle strength index of the respiratory muscle training group was 61.80%, its average Fugl-Meyer score was 75 and its average Berg balance score was 38. All were significantly better than before the treatment and better than the control group′s averages at the same time point. Spearman correlation analysis found significant correlation among the three measurements.Conclusions:Combining inspiratory muscle training with diaphragm resistance training can significantly improve the inspiratory muscle strength of stroke survivors, and promote the recovery of their motor and balance functions.
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@#Objective To observe the effects of abdominal torsion movement on depression, constipation, motor symptoms and quality of life in patients with Parkinson's disease. Methods From March to October, 2021, 66 patients with Parkinson's disease hospitalized in Affiliated Hospital of Shandong University of Traditional Chinese Medicine were randomly divided into control group (n = 33) and experimental group (n = 33). Both groups were given conventional rehabilitation training and medication, and the experimental group was given abdominal torsion movement in addition, for eight weeks. They were assessed with Hamilton Depression Scale (HAMD), Chronic Constipation Severity Scale (CSS), Timed "Up and Go" Test (TUGT), Berg Balance Scale (BBS), and the Parkinson's Disease Questionnaire (PDQ-39), and the movement track length and ellipse area of pressure center within 30 seconds were compared before and after treatment. Results Before treatment, there was no significant difference in the scores of HAMD, CSS, BBS and PDQ-39, and the time of TUGT, the movement track length of pressure center and movement ellipse area between two groups (P > 0.05). All the indexes significantly improved after treatment in both groups (t > 9.674, P < 0.001), and were better in the experimental group than in the control group (t > 3.120, P < 0.01). Conclusion Abdominal torsion movement could improve the symptoms of depression, constipation and motor, and quality of life in Parkinson's patients.
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@#Objective To explore the effects of dynamic neuromuscular stabilization techniques on the exercise capacity,balance function and walking function of Parkinson’s patients.Methods A total of 46 Parkinson’s disease patients were selected and divided into control group (n=23) and study group (n=23) using a random number table method.The control group was given conventional drugs and rehabilitation training,30 min/time,1 d/time,5 d/week;the study group was treated with dynamic neuromuscular stabilization technology on the basis of the control group,30 min/time,1 d/time,5 d/week.Before treatment,4 weeks after treatment,and 8 weeks after treatment,the third part of the Unified Parkinson’s Comprehensive Rating Scale (UPDRS-Ⅲ),the peak torque of the back muscles (PT),and the forward and backward movement distance of the trunk pressure center (AP-SD),timed up-walking test (TUGT) were evaluated.Results Before treatment,there was no significant difference in UPDRS-Ⅲ,PT,AP-SD and TUGT between the two groups (P>0.05).The UPDRS-Ⅲ,PT,AP-SD,and TUGT groups of the two groups improved after 4 weeks of treatment and 8 weeks of treatment compared with those before treatment,and the experimental group had UPDRS-Ⅲ ［(18.76±3.59) points］ at 8 weeks of treatment,PT ［(128.09±23.74)N·m］,AP-SD［(60.68±18.63) mm］,TUGT［(22.71±3.43) S］ improved significantly (P<0.05).Conclusion DNS can effectively improve the motor dysfunction of Parkinson’s patients,improve the patient’s back muscle strength,balance function and walking ability.
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Objective:To analyze the respiratory muscle functioning of stroke survivors and explore factors influencing it so as to provide references for clinical rehabilitation intervention.Methods:A total of 139 stroke survivors were randomly divided into a respiratory muscle dysfunction group and a control group based on the actual strength of their inspiratory muscles divided by the predicted strength. Beyond typical clinical data, information was collected about the subjects′ exercise habits. Balance ability was evaluated using the Fugl-Meyer assessment scale (FMA) and the simplified Berg Balance Scale (BBS). Multivariate logistic regression was used to analyze the factors influencing respiratory muscle dysfunction.Results:Among the 139 patients, 81 (58.27%) had respiratory muscle dysfunction. Univariate analysis showed that patients with stroke in the brainstem and dysphagia and those with poor FMA and BBS scores were at significantly greater risk of respiratory muscle dysfunction. Logistic regression analysis showed that dysphagia, FMA and BBS scores were factors independently predicting respiratory muscle dysfunction among stroke survivors, with dysphagia as a risk factor, and high FMA and BBS scores as protective factors.Conclusion:Some stroke survivors may have respiratory muscle dysfunction, and dysphagia is a risk factor, while the high FMA and BBS scores are protective.
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Objective@#To have a profound understanding of anti-N-methyl-D-aspartic receptor (anti-NMDAR) encephalitis, through the clinical analysis of 5 cases of anti-NMDAR encephalitis, and literature review.@*Methods@#This is a retrospective analysis. Five cases of anti-NMDA receptor encephalitis treated from May 2010 to June 2015, in the Department of Neurology, Beijing Friendship Hospital affiliated to Capital Medical University, were included in this study. The clinical data, including clinical manifestation, past history, radiological features, serum and cerebral spinal fluid examinations, treatment and prognosis, were analyzed.@*Results@#Among the 5 cases, 3 young female and 2 middle-to old-aged male. The clinical features of the onset was mental and behavior disorder, as well as seizure and extrapyramidal features, like facial and limbic involuntary movements or tremor. Coma and hypopnea was severe in 3 young female cases, needing assistance of mechanical ventilator, while the manifestation of 2 male patients was much mild, need not assisted respiration. 1 case had teratoma of ovary, 1 case had Vogt-Koyanagi-Harada syndrome. The anti-NMDA receptor antibody was positive in cerebraospinal fluid of all 5 cases, but in serum of 3 cases, serum and CSF Epstein-Barr virus (EBV) IgM antibody was positive in 1 case, while herpes simplex I virus (HSV-1) IgM antibody positive in another case, and anti-myelin oligodendrocyte glycoprotein (MOG) antibody was seen in serum and CSF in 1 case. The time interval from the onset to treatment was 10-37 d (18.8±9.8 d). IVIG was used in all of the 5 cases, glucocoticoid in 4 cases, and plasma exchange in 3 cases. One case with Vogt-Koyanagi-Harada syndrome, having a long time before diagnosis and treatment, died, while the other 4 cases had good prognosis, and had no relapse.@*Conclusions@#Mental and behavior disturbance is common at onset of anti-NMDAR encephalitis. The radiological and lab examination may be normal. It may be accompanied with HSV-1 or EBV infection, anti-MOG antibody may be positive in this disease. Active treatment is important.
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The basic pathogenesis of hypersalivation syndrome is the deficiency of spleen and kidney, which results in the imbalance of water metabolism and intake disorder. There are two different characters included in polysialia and profuse spittle. Therefore, dialectics should start from the spleen and kidney, and warming yang and resolving dampness, strengthening spleen and reinforcing kidney should be the treatment. Two medical cases for the treatment of hypersalivation syndrome were illustrated in this article. Lizhong Decoction and Linggui Zhugan Decoction were the basic prescriptions, and combined with the Chinese materia medica with the function of reinforcing kidney andintaking the saliva, with obvious efficacy.
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To study the visual magnocellular deficit in alphabetic and Chinese developmental dyslex?ia from behavioral,neural mechanism and intervention studies,critical words in Chinese and English (de?velopmental dyslexia and magnocellular pathway or dorsal stream or contrast sensitivity or coherent mo?tion ) were searched in Chinese and English databases(CNKI,PubMed,ScienceDirect,etc.) from Septem?ber to December,2015. Forty?three relevant articles which aimed to investigate the visual magnocellular defi?cit in developmental dyslexia were selected among 75 articles according to the searching result and the objec?tive of the present study. The results showed that alphabetic studies consistently consistently manifested the magnocellular deficit in developmental dyslexia from the aspects of behavioral performance,neural activities and intervention effects. However,whether the deficit was the cause or the consequence of dyslexia remains controversial. In Chinese,most of studies on magnocellular deficit of developmental dyslexia were behavioral. There were few studies from aspects of neural mechanism and intervention. Alphabetic and Chinese studies consistently manifested magnocellular deficit in developmental dyslexia,suggesting the consistency across lan?guages. However,more comprehensive studies are required to further explore the causal relationship between magnocellular deficit and developmental dyslexia.
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Objective To study on the neural mechanism of deficits in Chinese developmental dyslexia from the aspects of the phonological processing,orthographic skills,visual magnocellular function and cerebellum function.Methods Critical words in Chinese and English (e.g.dyslexia,reading development,Chinese,neural) and formula (e.g.Chinese and (reading development) and (neural or neuroimage or fMRI or ERP or brain area) related with the present topic were searched among the article abstracts in Chinese and foreign databases (e.g.CNKI,Pubmed,Sciencedirect) from July to December,2014.Results Fifty-two relevant articles were gained access to the database.Referring to the present topic,research on the neural mechanism of dyslexia with neuroimaging technique was reserved,while the studies in which the reading impairment of the participants was caused by acquired factors were eliminated.Finally,thirty-three valid articles were retained.Conclusion According to previous studies,although there might be similarities in cognitive deficits of dyslexia between alphabetic languages and Chinese,it was still found that the Chinese children with developmental dyslexia exhibited abnormal neural activities and impaired brain structures in areas associated with Chinese phonology (i.e.left middle frontal gyrus,which was different from the left inferior fiontal gyrus always related with phonological processing in alphabetic languages) and orthographic skills (right occipitotemporal areas which was responsible for the visuospatial processing),revealing language specificity of Chinese to some extent.However,some other studies reported the similarities in neural mechanisms of dyslexia across languages.Therefore,more studies were required to further examine the crosscultural mechanism of the neural activity regarding the developmental dyslexia.Meanwhile,researches on the aspects of general perception showed Chinese dyslexic individuals had deficits in visual magnocellular function,and cerebellum.Future studies were required to explore the relationship between the linguistic and non-linguistic deficits.
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Developmental dyslexia is a specific learning disability. The cerebral mechanism of development dyslexia is an important topic that has fascinated many researchers. With the introduction of brain imaging in studies of cerebral mechanism of development dyslexia, many achievements have been made. Studies of developmental dyslexia structure image found that development dyslexia showed brain structure abnormal in the parietotemporal region, occipitotemporal cortex, inferior frontal gyrus, and cerebellum et al, manifesting either in one specific area or by the asymmetry of one area; the functional image studies revealed that development dyslexia showed activity abnormal in most regions that proved to display structure abnormality; studies of brain functional connectivity demonstrates that the abnormality of development dyslexia happened not only in the connection between front-back part in one cerebral hemisphere, but also in the connection between the two hemispheres. In addition, some studies indicate Chinese development dyslexia has different brain mechanisms compared to that of alphabetic languages. These findings provide valuable insight for future developmental cerebral mechanisms research and for the expansion of Chinese development dyslexia research.
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@#ObjectiveTo investigate the clinical feature peripheral neuropathy and vasculopathy after acrylamide toxication. Methods2 young male patients with peripheral neuropathy who had exposed to acrylamide for job more than one year were reported.ResultsNeuroelectrophysiological examination showed marked abnormalities in both peripheral and central nerve conduction in both patients. Sural nerve biopsies revealed axonal degeneration, Wallerian degeneration and giant axon with accumulated neurofilaments. Additonally, vasculopathies including prominant thickness of arterial intesma and basal membrane of capillary as well as apoptosis of vascular pericyte, were evident. ConclusionAxonal degeneration and vascular involvement has been found in acrylamide toxication. Vascular impairment maybe plays an important role in the pathogenesis of neuropathy.
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Neurolymphomatosis(NL) is characterized by lymphomatous infiltration of the peripheral nervous system. We report a case of neurolymphomatosis(NL) which was confirmed by sural nerve biopsy. Sural nerve specimen from a 49-year-old female patient with weakness of limbs was examined with routine histochemical and immunohistochemistry staining, in which the first antibodies against CD3, CD20, CD45, CD45RO and CD68 were used. Numerous T-lymphoma cells invaded in the adipose tissue of epineurium of sural nerve. The nerve biopsy showed marked axonal degeneration of myelinated fibers. The clinical and histopathologic findings confirmed the diagnosis of neurolymphomatosis.