Serum concentrations of lipids and apolipoprotein E in angiographically defined coronary artery disease patients.

Apolipoprotein (apo) E is an important component of plasma lipoproteins and influences lipoprotein metabolism through its action as a receptor ligand. The association of serum apo E concentrations and coronary artery diseases (CAD) was investigated in 100 CAD patients (71 men, 29 women, mean age 62.0 years) and 155 healthy volunteers (87 men, 68 women, mean age 50.6 years). Patients with CAD had lower serum apo E concentrations (5.1+1.3 mg/dL) than the healthy volunteers (5.9+1.8 mg/dL, p <0.001). There were no significant differences between the number of disease vessels and the concentration of serum apo E. Serum apo E concentrations may have an anti-atherosclerotic effect and the serum apo E levels could be a useful parameter for defining cardiovascular risk factor.