الملخص
Despite the evolution of modern medicine, traditional medicine remains widespread in developing countries and its use continues to increase in industrialized countries.It is the same way that the effectiveness of the hydroalcoholic extract of Terminalia ivorensis was tested on the feet fungus disease of volunteers. Objective: The present work is oriented in the preparation of an antimicrobial hydroalcoholic extract of Terminalia ivorensis, a medicinal plant in order to enhance it. Materials and Methods: One hundred (100) grams of powder from trunk bark’s Terminalia ivorensis were extracted by homogenisation in a solvent mixture of 70% ethanol and 30% distilled water in a blender. After six grinding cycles, the homogenate obtained in each case was first wrung out in a clean white cloth square and then successively filtered twice on cotton wool and on Whatman 3 mm filter paper. The filtrate obtained was dried in a Venticell oven. The powder obtained constitutes the hydroalcoholic extract (or The 70% hydroethanolic extract). The 70% hydroethanolic extract of Terminalia ivorensis obtained was mixed with water to obtain a pasty liquid form before being tested on feet fungus disease using a cotton ball. Results: The extract had activity on these different shapes of feet fungus disease with a marked improvement. The volunteers who finished their treatment have been cured of feet fungus disease. Conclusion: The treatment results obtained revealed that the hydroalcoholic extract has good antimicrobial activity. The hydroalcoholic extract can be an undeniable source for the development of Improved Traditional Medicines (ITM) against feet fungus disease.
الملخص
Bites of Bitis Rhinoceros (Viperidae) usually cause a hemorrhagic syndrome in the victims. This is a medical emergency. Antivenom immunotherapy remains effective. However, its availability and cost still limiting its use in Africa in general and in Côte d'Ivoire particularly. The roots of a plant of the Annonaceae family (Annona senegalensis) are used in Côte d'Ivoire to treat cases of envenomations by Viperidae. The objective of this work is to study the modulation of the effect of Bitis rhinoceros venom on coagulation parameters by the hydroethanol extract of Annona senegalensis leaves. The phytochemical study of the plant was carried out by monitoring effect of the venom on three blood coagulation parameters (PT, APTT, Fibrinogen) from healthy individuals in the presence and absence of the hydro-ethanolic extract. Phytochemistry revealed the presence of saponins, tannins, and polyphenolic compounds including flavonoids in this plant. The study of the effect of the venom showed that at the concentration of 10-2 mg/mL the venom of Bitis rhinoceros modifies some coagulation parameters by the decrease of half of the prothrombin rate, the increase of the coagulation time. It has no effect on the fibrinogen level. The effect of this venom is inhibited by 1 mg/mL of the hydroethanol extract. The leaves of Annona senegalensis contain molecules that could neutralize the action of the venom in the coagulation disorder.
الملخص
This study aims to improve the nutritional quality of traditional porridge intended for young children with moderate malnutrition. The biochemical and nutritional characteristics of three supplement porridges enriched with dried leaves Corchorus olitorius and Anacardium occidental were determined according to standard methods. The results revealed that enrichment with these two ingredients significantly improved the proportion of dry matter of porridges enriched with high contents in those containing only Western Anacardium BC2 (17.33 ± 0.83%) and that enriched with both Corchorus olitorius and Anacardium occidental BC4 (18.0 ± 0.5%) compared to the traditional non-enriched porridge BC1 (13.23 ± 0.41%) and that enriched with Corchorus olitorius only BC3 (14.63±0.56%). With regard to fat, the three enriched porridges showed significantly high levels: 16.00±0.00% (BC2); 13.75±0.25% (BC3); 19.25±0.35% (BC4) compared to porridge BC1 (12.75±0.25%). As for carbohydrates, enrichment did not lead to a significant increase in levels. On the other hand, the levels of proteins experienced a significant increase between 2.66 ± 0.08% (BC3) and 3.08 ± 0.05% (BC4). All the porridges showed high energy densities with values ranging between 463.43±1 Kcal/100 g (BC1) and 488.21±1 Kcal/100 g (BC4). Regarding micronutrients, the results indicated a significant increase in trace elements with higher mineral values in the porridge BC4 (Zinc: 05.05±0.06) and BC3 (Calcium: 60.91±0.07 mg /100 g; Iron: 21.80±0.20 mg/100 g; Copper: 01.57±0.04 mg/100 g; Phosphorus: 280.41±0.48 mg/100 g). The contents of fat-soluble vitamins, in particular vitamin A (BC2: 25.10±0.14 µg/100 g; BC3: 41.00±0.45 µg/100 g; BC4: 33.59± 0.12 µg/100 g) and water-soluble vitamins B2 (BC2: 12.39±0.01 mg/ 100g; BC3: 10.81±0.01 mg/100 g; BC4: 15.01±0.01 mg/100 g) and B9 (BC2: 23.05±0.25 mg/100 g; BC3: 27.13±0.29 mg/100 g; BC4: 35.16±0.36 mg/100 g) experienced a significant increase in the enriched porridge compared to the control. There is also a significantly high content of essential amino acid (leucine) with values between (37.78±0.05 and 78.31±0.9 g/100 g) in the enriched porridge compared to the control (18.51±0. 05 g/100 g). All the porridges are very rich in essential fatty acids, linoleic acid (Ω6) with contents between 19.73±0.01 and 22.59±0.01 g/100 g and linolenic acid (Ω3) with contents between 01.20±0.00 and 07.95±0.00 g/100 g, and this in accordance with the recommended values for moderate acute malnutrition (MAM). This nutritional supplementation also significantly improved their antioxidant properties with DPPH values varying between 47.52±3 and 56.91±1.55% compared to the control (41.58±4.34%). Enriching these porridges with Corchorus olitorius and Anacardium occidental improved their nutritional quality in accordance with the recommended dietary intakes for my moderately malnourished for most essential nutrients. These enriched porridges could then be recommended not only for the nutritional rehabilitation of MAMs and also to prevent certain chronic diseases such as obesity and cardiovascular diseases.