الملخص
Cancer immunoediting is crucial to understand the success or failure of a tumor. Immune system plays dual roles in tumor development and progression, promoting or suppressing tumor depending on tumor microenvironment and the events that lead to initiation of carcinogenesis. The immune system has potential to recognize and destroy tumors, and thus function as a primary defense mechanism against cancer. On the other hand, unresolved immune responses can result in the growth and progression of cancer. Objectives: The host immune system determines tumour fate in three phases (Elimination, Equilibrium and Escape) and ac- cording to this theory, it blocks adaptive and innate tumour responses or promotes conditions that favour tumour progression. Conclusion: The purpose of this review is to emphasise the importance of immunity in tumour promotion and suppression.
الملخص
Fibrolipoma is a benign tumor which is classified as a histological variant of conventional lipoma. It rarely occurs in oral and maxillofacial region. When present, it occurs as a soft, smooth surfaced nodular mass that can be pedunculated or sessile. Most of the lesions are less than 3 cm in size, although it may vary. Fibrolipomas mostly affect buccal mucosa and buccal vestibule and cause functional and cosmetic disabilities. Herniation of buccal pad of fat caused by trauma may also mimic lipoma. Hence, accurate histopathological examination of lipomas is important for a correct treatment plan. Here, we present 2 cases of oral fibrolipoma that presented on the retromolar triangle area and alveolar ridge in relation to missing maxillary right first molar.
الملخص
Congenitally missing teeth are not rare. However, their association with other dental anomalies has always been a topic of interest in the profession. Occurrence of peg-shaped incisors in the mandibular arch is a rare finding. Strong association has been suggested between hypodontia and microdontia. Treatment approach has to be case specific and depends on the condition of primary predecessor, number of missing teeth, status of occlusion/occlusal condition and patient/parent’s preferences. This paper reports an unusual case of bilateral agenesis of permanent mandibular canines and unilateral agenesis of mandibular incisors, in association with a rare finding of peg-shaped mandibular lateral incisor in a 7-year-old Indian female.