الملخص
Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosis and both patients were treated with high leucovorin doses and management of associated complications. In one patient, pregnancy continued, giving birth to a newborn with cranial, face and limb malformations. The second patient had a late rescue with leucovorin and was discharged with a persistent sensory motor neuropathy. Considering the severity of complications and that patients may deny its use, when there is reasonable clinical suspicion of methotrexate intoxication, leucovorin treatment should be started
الموضوعات
Humans , Female , Pregnancy , Adolescent , Adult , Poisoning/drug therapy , Methotrexate/poisoning , Leucovorin/administration & dosage , Pancytopenia/chemically induced , Dermatitis, Exfoliative/chemically induced , Abortion, Induced/adverse effects , Transaminases/blood , Infant, Newborn, Diseases/chemically inducedالملخص
Se presenta una serie clínica de tres casos de quiste ovárico fetal diagnosticado en el período antenatal. Se realiza una revisión de la literatura, se discute el diagnóstico diferencial y el manejo perinatal
الموضوعات
Humans , Female , Pregnancy , Infant, Newborn , Adult , Pregnancy Complications , Ovarian Cysts , Ultrasonography, Prenatal/methods , Cholestasis, Intrahepatic/etiology , Diagnosis, Differential , Labor, Induced , Pregnancy Complications/therapy , Pregnancy Outcome , Ovarian Cysts/complications , Ovarian Cysts/diagnosisالملخص
Se presenta un caso clínico de ureterocele diagnosticado a las 37 semanas de gestación. Se discute el manejo perinatal y revisión de la literatura