Your browser doesn't support javascript.
loading
تبين: 20 | 50 | 100
النتائج 1 - 1 de 1
المحددات
إضافة المرشحات








اللغة
النطاق السنوي
1.
Zhongguo yi xue ke xue yuan xue bao ; Zhongguo yi xue ke xue yuan xue bao;(6): 728-731, 2008.
مقالة ي صينى | WPRIM | ID: wpr-259093

الملخص

<p><b>OBJECTIVE</b>To investigate the expressions of prostate stem cell antigen (PSCA) and Claudin-4 in human pancreatic carcinoma and to discuss its role in the ontogenesis of pancreatic cancer.</p><p><b>METHODS</b>Pancreatic carcinoma tissue microarray was constructed, containing 100 cores of 10 normal adult pancreas tissues, 12 chronic pancreatitis tissues, and 78 pancreatic carcinomas. The expressions of PSCA and Claudin-4 were detected using immunohistochemical method and the relationship between PSCA and Claudin-4 and the pancreatic carcinoma was analyzed.</p><p><b>RESULTS</b>The positive expression rates of PSCA and Claudin-4 protein in pancreatic carcinoma were 79. % and 88. % respectively. PSCA and Claudin-4 staining were more intense in malignant cells than in chronic pancreatic tissues and normal adult pancreas tissues. No evidence was found for an association between expressions of PSCA and Claudin-4 and other variables, including gender, age at surgery, and tumor grade.</p><p><b>CONCLUSIONS</b>The expressions of PSCA and Claudin-4 are related to the pancreatic carcinomas. PSCA and Claudin-4 play a role in the development of pancreatic cancer, but PSCA and Claudin-4 are not correlated with the clinical pathology of tumor.</p>


الموضوعات
Adult , Aged , Female , Humans , Male , Middle Aged , Antigens, Neoplasm , Carcinoma , Genetics , Metabolism , Pathology , Claudin-4 , GPI-Linked Proteins , Gene Expression Regulation, Neoplastic , Membrane Glycoproteins , Genetics , Metabolism , Membrane Proteins , Genetics , Metabolism , Neoplasm Proteins , Genetics , Metabolism , Pancreatic Neoplasms , Genetics , Metabolism , Pathology , Up-Regulation
اختيار الاستشهادات
تفاصيل البحث