الملخص
Objective@#Schizophrenia is a common mental disorder, and mitochondrial function represents a potential therapeutic target for psychiatric diseases. The role of mitochondrial metabolism-related genes (MRGs) in the diagnosis of schizophrenia remains unknown. This study aimed to identify candidate genes that may influence the diagnosis and treatment of schizophrenia based on MRGs. @*Methods@#Three schizophrenia datasets were obtained from the Gene Expression Omnibus database. MRGs were collected from relevant literature. The differentially expressed genes between normal samples and schizophrenia samples were screened using the limma package. Venn analysis was performed to identify differentially expressed MRGs (DEMRGs) in schizophrenia. Based on the STRING database, hub genes in DEMRGs were identified using the MCODE algorithm in Cytoscape. A diagnostic model containing hub genes was constructed using LASSO regression and logistic regression analysis. The relationship between hub genes and drug sensitivity was explored using the DSigDB database. An interaction network between miRNA-transcription factor (TF)-hub genes was created using the Network-Analyst website. @*Results@#A total of 1,234 MRGs, 172 DEMRGs, and 6 hub genes with good diagnostic performance were identified. Ten potential candidate drugs (rifampicin, fulvestrant, pentadecafluorooctanoic acid, etc.) were selected. Thirty-four miRNAs targeting genes in the diagnostic model (ANGPTL4, CPT2, GLUD1, MED1, and MED20), as well as 137 TFs, were identified. @*Conclusion@#Six potential candidate genes showed promising diagnostic significance. rifampicin, fulvestrant, and pentadecafluorooctanoic acid were potential drugs for future research in the treatment of schizophrenia. These findings provided valuable evidence for the understanding of schizophrenia pathogenesis, diagnosis, and drug treatment.
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Objective To evaluate the impact of standardized health management and treatment on asthma control and the quality of life of the patients.Methods One hundred asthma patients were recruited in our hospital and were assigned to the health management (n=50) or the control group (n=50).The control group subjects were treated with conventional therapy,while those of the heahh management group received standardized asthma management and health education.The control of asthma and the quality of life were evaluated at baseline and six months after the intervention.Student's t test and Chisquare test were used for data analysis.Results At 6 months treatment,the rate of effective control of asthma of the health management group (56％) was higher than that of the control group (22％) (x2=12.15,P＜0.05).In the control group,the activity limitation,asthma symptoms,mentality asthma,the stimulus response,the personal health concerns and the total score of Quality of life were (47.4±5.8),(35.3±6.2),(28.2±4.3),(22.7±3.5),(17.6±3.9),(151.2±14.7),and they were (38.2±4.5),(27.1±4.8),(23.1±5.7),(18.3±4.3),(13.7±4.2),(121.4± 12.6) in the control group,they were all significantly higher in the management group than that of control group(t values were 6.17,4.42,4.98,5.76,5.43 and 6.35,all P＜0.05).Conclusion The standardized health management and the health education can effectively control asthma and significantly improve the quality of the patient's life.
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Objective To evaluate the impacts of health management on quality of life of patients with chronic obstructive pulmonary disease (COPD).Methods Ninety COPD in-or out-patients were assigned to two groups according to visit date.The control group was treated with conventional therapy,and the observation group obtained conventional therapy + standard health management for 6 months.Cigarette smoking,6 MWT/m and The St George's Respiratory Questionnaire (SGRQ) were evaluated before and after the intervention.Results At 6 months,the ratio of current cigarette smoking of the observation group was much lower than that at baseline (x2=4.464,P＜0.05),6 MWD/m was significantly increased (337.2±82.6 vs 372.0±76.3,t=-7.14,P=0.00),and the scores of respiratory symptoms,limitation of motion and influence of disease and total score of SGRQ were significantly reduced (t values were 6.15,5.18,4.70 and 5.07,respectively; all P＜0.05).Conclusion Standard health management could decrease the rate of current cigarette smoking and improve exercise tolerance and the quality of life of COPD patients.
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Objective To explore the effect of health education and comprehensive nursing intervention on quality of patients with lung cancer.Methods One hundred lung cancer patients who were treated with chemotherapy from February 2010 to February 2013 in our hospital were selected and assigned to the intervention group (n=50) and the control group (n=50).The participants in the control group received conventional anti-cancer drug and routine primary care,however those of the intervention group additionally obtained health education and comprehensive nursing intervention.The Zung Anxiety Scale (SAS),Depression Rating Scale (SDS) and the core quality of life questionnaire (QLQ-C30) were used to evaluate the quality of life of the patients.Paired samples t test and ANOVA were used for data analysis.Results Differences of age,gender,disease duration,SAS,SDS score and EORTC QLQ-C30 score were not statistically significant between the two groups (all P＞0.05).After the intervention,SAS and SDS scores of the control subjects were 58.8±7.6 and 49.5±10.1 respectively,and SAS and SDS scores of the intervention group were 46.5±7.8 and 37.4±9.2 respectively (t velues were 5.347 and 6.215,respectively; both P＜0.05).Quality of life scores in the intervention group were as followed:general condition 57.2± 18.3,physical fitness 63.0±25.9,mutual affection 67.3±23.3,cognitive score 75.4±28.2,social role 67.7±24.8 and function scores 58.5±22.3.Quality of life scores in the control group were as followed:general condition 47.3±23.0,physical fitness 54.9±26.6,mutual affection 60.4±19.1,cognitive score 66.2±25.8,social role 54.1±26.2 and function scores 49.4±21.5 (t values were 5.725,6.144,5.021,5.702,7.137 and 6.357,respectively; all P＜ 0.05).Conclusion Health education and comprehensive nursing intervention for lung cancer patients may reduce their anxiety and depression symptoms and improve the quality of life.
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ObjectiveTo investigate the impact of health education and psychological intervention on quality of life of patients with asthma.MethodsNinety-six patients with bronchial asthma were assigned to the treatment group and the control group. The participants in the treatment group were treated with routine therapy and health education and psychological intervention.Results The awareness of bronchial asthma,self monitoring of health condition,and simple strategies to treat acute or serious asthma were improved in the treatment group. The overall effective rate of the treatment group was significantly higher than that of the control group (93.75％ vs 62.5％,P ＜0.01 ),and forced expiratory volume in one second (FEV1),peak expiratory flow (PEF) and ACT score were significantly improved (all P ＜ 0.01 ).Moreover,episode of bronchial asthma was significantly reduced after the combined intervention (P ＜0.01 ).ConclusionHealth education and psychological intervention may contribute to effective prevention and treatment of asthma,improved quality of life of patients,and reduced family and social economic burden.
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Objective To analyze the psychological characteristics of stroke patients and the effects of psychological interventions on their functional rehabilitation.Methods A total of 180 stroke patients with hemiplegia were randomly assigned to the control group ( n =90) or the treatment group ( n =90 ).Those of the control group received conventional drug therapy and rehabilitation programme,and those of the treatment group were additionally given psychological intervention.Symptom checklist (SCL-90) and the WHO QOL-100 checklist were used to assess the effect of psychological intervention on mental health of the participants.Results Before the treatment,the difference of SCL-90 results was not statistically significant between the two groups ( P ＞ 0.05 ).At 3 months,SCL-90 results of the treatment group was lower in comparisou with the baseline level ( 120.3 ± 21.2 vs 133.1 ± 34.1 ) and the control group ( P ＜ 0.05 ).However,there was no statistical significance in the control group before and after the treatment ( P ＞ 0.05 ).SCL-90 and the WHO QOL-100 checklist results in the treatment group were significantly different before and after the treatment ( P ＜ 0.05 ).The SCL-90 showed no significant difference in the control group before and after the treatment (P ＞ 0.05 ).Conclusion Timely and appropriate psychological intervention could improve the functioning,reduce disability and improve the quality of life of stroke patients.
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Objective To explore the effects of psychological intervention on negative emotion and quality of life of the patients with chronic obstructive pulmonary disease (COPD). Methods A total of 80 patients with COPD were divided into the psychological intervention group and the control group. The psychological intervention group received routine treatment + psychological intervention; the control group only received routine treatment. SCL-90 symptom checklist and St George'S Respiratory Questionnaire (SGRQ) scores before and after the treatment were assessed. Results There was no significant difference in each score between the 2 groups at baseline ( P ＞ 0. 05 ). After 3 months' treatment, the scores of the 2 groups was declined; somatization, obsession, anxiety, and depression were significantly improved compared with baseline. There was no significant difference in SGRQ respiratory symptoms, disease impact and the SGRQ indicators at baseline ( P ＞ 0. 05 ). After the invention, there showed significant difference in the treatment group in SGRQ respiratory symptoms, disease impact and the SGRQ indicators compared with baseline (P ＜0. 05 ). Conclusion Psychological intervention could improve negative mood and the quality of life of patients with COPD.