الملخص
@#Abstract: As the scale and volume of China-African cooperation continue to expand, the opportunities inherent in China-African public health cooperation are also on the rise. Malaria prevention and control is one of the primary domains of China-African public health cooperation. Especially after China's elimination of malaria, incorporating China's experience into the local context to accelerate the control and elimination of malaria in Africa, is a critical scientific problem. This article retrospectively analyses the historical China-African cooperative projects on malaria prevention and control such as the artemisinin compound project for rapid clearance of malaria, the China-UK-Tanzania pilot project, and the institution-based network of China-Africa cooperation on malaria elimination (INCAM), cooperation with the World Health Organization, and the contribution of domestic non-governmental organizations. The article also examines the challenges faced in the China-African cooperation for controlling and eliminating malaria and envisions future cooperation directions.
الملخص
Kruppel-like factor 6 (KLF6) was reported as tumor suppressor in multiple cancers.However,loss of chromosomal locus spanning KLF6 is relatively infrequent in previous published studies.To explore the role of KLF6 in hepatocellular carcinoma (HCC),we examined the gene for expression change,loss of heterozygosity (LOH) and mutation in 26 HCC samples.The expression levels of KLF6 were significantly down-regulated in HCCs,as detected by qRT-PCR.LOH occurred in 11 (52%) of 21 tumors,and all the samples with LOH showed KLF6 down-regulation.The mutational frequency was 24%,and sequence changes located in activation domain of KLF6.Furthermore,MTT assay showed a significant antiproliferative effect of the wt KLF6 transfected in HepG2 hepatoblastoma cells.Fluorescence-activated cell sorting analysis revealed that KLF6 could induce apoptosis.These findings indicate that deregulation of KLF6,together with genetic abnormalities of allelic imbalance and mutations,may play a role in HCC pathogenesis.