Screening of Core Prescriptions for Tremors Based on Integrated Strategy of "Empirical Prescriptions in Ancient Books-medical Cases by Prestigious Doctors-computational Analysis" / 中国实验方剂学杂志

ObjectiveBased on the integrated strategy of "empirical prescriptions in ancient books-medical cases by prestigious doctors-computational analysis"， this study aims to explore and analyze the prescriptions and medical cases for treating tremors in traditional Chinese medicine （TCM）， predict their efficacy， and obtain the core prescriptions for treating tremors in TCM， providing references for clinical application and new drug development. MethodThe Chinese Medicine Prescription Database and the China National Knowledge Infrastructure （CNKI） were searched for relevant prescriptions and medical cases for treating tremors in TCM to establish a database of prescriptions for tremors. The Traditional Chinese Medicine Inheritance Computer System （V3.0） was used to analyze and explore the medication rules including drug frequency， properties， flavor， meridian tropism， and pharmacological effects， as well as core drugs and formula associations. A multi-target drug efficacy prediction platform based on network robustness was used to evaluate the predicted efficacy of the core prescriptions obtained. Based on the integration of ancient prescriptions， prestigious doctors' medical cases， and network analysis results， the priority level of the developed prescriptions was determined through comprehensive evaluation. ResultA total of 81 ancient prescriptions were screened， involving 246 drugs， and 171 prescriptions were screened from prestigious doctors' medical cases， involving 278 drugs. The frequently used TCM drugs were mostly warm in nature and sweet in flavor， mainly acting on the liver， spleen， and kidney meridians. In terms of efficacy， they were mainly effective in tonifying deficiency， soothing liver and extinguishing wind， activating blood and resolving blood stasis， clearing heat， and resolving exterior. Through association rules and K-means clustering， the core prescriptions were composed of high-frequency drugs such as Glycyrrhizae Radix et Rhizoma， Ginseng Radix et Rhizoma， Astragali Radix， Atractylodis Macrocephalae Rhizoma， Angelicae Sinensis Radix， Poria， Gastrodiae Rhizoma， and Uncariae Ramulus Cum Uncis. Drug combinations mainly focused on tonifying Qi and nourishing blood， with the additional functions of calming wind and dredging collaterals. Clustering analysis of core prescriptions from ancient prescriptions and prestigious doctors' medical cases， as well as multi-target drug efficacy prediction， showed that Combination 1 had the highest disturbance score on the disease network. Furthermore， comparative analysis revealed consistent results with both the analysis of ancient prescriptions and prestigious doctors' medical cases， indicating its optimal development potential based on theoretical inheritance and empirical practice. In comparison， Combinations 3， 2， and 4 were less utilized in contemporary clinical practice， with lower rankings in network disturbance scores， suggesting that their development value still warranted further exploration. ConclusionTCM clinical treatment of tremors emphasizes the regulation of the liver， spleen， and kidney. In line of syndrome differentiation， drugs potent in soothing liver， extinguishing wind， activating blood， and resolving blood stasis are added based on deficiency-tonifying drugs. The core prescriptions based on Glycyrrhizae Radix et Rhizoma， Angelicae Sinensis Radix， Paeoniae Radix Alba， Astragali Radix， Poria， and Atractylodis Macrocephalae Rhizoma （combination 1） have the highest potential development value. The integrated strategy "empirical prescriptions in ancient books-medical cases by prestigious doctors-computational analysis" can be used for the screening of candidate prescriptions for new TCM drugs.

ZHANG Deying's Cases of Treating Acne from Phlegm / 浙江中医药大学学报

[Objective]To summarize the characteristics and experience of Professor ZHANG Deying in treating acne from the perspective of phlegm syndrome.[Methods]By following the clinical study of Professor ZHANG's clinic,the medical records of acne treatment were sorted out,three typical cases were selected,and combined with the classical theories of traditional Chinese medicine,the unique insights and clinical experience of Professor ZHANG on phlegm syndrome theory were analyzed and summarized.[Results]According to the physical condition of people and the characteristics of acne,Professor ZHANG points out that the etiology and pathogenesis of acne are phlegm heat or phlegm fire invading the head,chest and causing local flesh rot.According to the spleen and stomach of middle-Jiao,the phlegm is a pathogenic factor of soil.In the treatment,the purpose of reducing phlegm can be achieved by reducing soil,multiplying wood to reduce soil and producing metal to eliminate soil,and then using heat-clearing drugs to clear the evil of upper-Jiao phlegm heat and cure acne.At the same time,it should be noted the relationship among the five elements,the phlegm is too excessive,easy to block the kidney water and cause kidney deficiency,the first treatment is reducing phlegm,after the removal of phlegm,tonifying the kidney can be effective,even some patients do not need to be tonified the kidney,and the kidney will slowly recover.[Conclusion]Professor ZHANG has unique understanding of the theory of phlegm syndrome,pointing out that the pathogenesis of acne is mostly phlegm fire or phlegm heat stagnation in the muscle surface,and the flesh rot.The main treatment should be to clear phlegm heat.Phlegm is the pathogenic factor of soil.Besides the method of reducing soil,according to the theory of five elements,there are also methods of multiplying wood to reduce soil and producing metal to eliminate soil.

Professor FAN Yongsheng's Academic Experience in Treating Systemic Juvenile Idiopatic Arthritis from the Latent Pathogens Warm Disease / 浙江中医药大学学报

[Objective]To review and summarize the academic experience of Professor FAN Yongsheng,one of the first session national famous traditional Chinese medicine masters,in the treatment of systemic juvenile idiopathic arthritis.[Methods]Through follow-up study,sorting out and analyzing typical medical records,and referring to relevant literature,combined with Professor FAN Yongsheng's works and clinical practice,Professor FAN Yongsheng's academic experience in the treatment of systemic juvenile idiopathic arthritis was summarized from two aspects of etiology,pathogenesis and treatment ideas,and one proven case was attached for evidence.[Results]Professor FAN Yongsheng believes that the pathogenic process of systemic juvenile idiopathic arthritis conforms to the law of the transformation of warm diseases Wei Qi Ying Xue,which is similar to the pathogenic characteristics of latent pathogenic febrile diseases.It is mostly caused by the deficiency of healthy Qi in the interior,combined with the invasion of external pathogens,hidden in the interior,waiting for opportunities,or triggered by external pathogens.Clinical application of fire stagnation requires dissipation,dispersing and expelling the latent pathogens;protecting the healthy Qi,moderating exorcism;sequential therapy,toxicity reduction and efficacy enhancement and other treatment ideas have achieved satisfactory clinical results in the treatment of this disease.In the test case,the initial manifestation of the patient was the pathogen lurking in Yin phase,dual blaze of Qi and Ying,and the treatment was to clear heat toxin and harmonize Ying,dispel wind and dredge collaterals;after treatment,rash regression and fever relieve,latent pathogens were affected from Yin to Yang and cardinal dysfunction,and the treatment was to reconcile cardinal,clear and expel the stagnant heat;when the pathogenic Qi disappeared gradually,the healthy Qi declined,the treatment was given to disperse and expel the heat,combined with invigorating the spleen and harmonizing the stomach.The whole process of treatment was permeated throughout dispersing latent pathogens,and at the same time reflecting Professor FAN Yongsheng's treatment ideas of flexible drug use,taking care of healthy Qi.[Conclusion]Professor FAN Yongsheng has achieved good clinical results in the treatment of systemic juvenile idiopathic arthritis based on the theory of latent pathogenic warm disease,and his academic experience is worthy of reference and promotion.

Promoting Innovative Development of Traditional Chinese Medicine Case Report Based on China Clinical Cases Library of Traditional Chinese Medicine / 中国实验方剂学杂志

China Clinical Cases Library of Traditional Chinese Medicine is built to promote the establishment of a scientific and technological talent evaluation system oriented on innovative value， ability and contribution in the backgroud of breaking the four only and setting new standards required by the document jointly issued by several national administrations and commissions. In the process of the construction， in order to further consolidate the foundation and ensure the quality and authority of case reports， we need to fully understand the origin and development of Chinese medical cases. Therefore， we clarified the development situation of Chinese medical cases by combing the characteristics of ancient and modern case reports， comparing the differences between Chinese and western medical case reports in terms of content and writing requirements， finally formed the main points of systematic case report norms and quality evaluation system， aiming to fully explore the unique advantages of Chinese medical cases in the fields of discipline development， scientific research innovation， clinical practice and guidance， talent evaluation and training， so as to promote its innovative development in a broader direction.

Analysis of Professor LAO Changhui's Experience in Differentiating and Treating Postinfective Cough / 浙江中医药大学学报

[Objective]To review and summarize the academic experience of Professor LAO Changhui in the treatment of postinfective cough.[Methods]By clinical shadowing,recording medical cases and reviewing literature,the clinical experience of Professor LAO in the treatment of postinfective cough was summarized from three aspects:etiology and pathogenesis,clinical treatment,feeding and nursing.Two medical records were attached to support it.[Results]Professor LAO believes that the postinfective cough belongs to the category of cough in traditional Chinese medicine and the key of differentiation lies in external and internal injury.The treatment should be carried out according to the physiological characteristics of lung"preferring moist,hating dryness and not resistant to cold",and prescription should be based on pathological products and functions of Zang-Fu organs.Xuanfei Huatan Decoction and Shegan Mahuang Decoction were the main prescriptions for patients whose postinfective cough was caused by external factors;while Liujunzi Decoction was the main prescription for patients whose postinfective cough caused by internal injury.This article also discussed dietary therapy for cough after infection.In the first case cited,Professor LAO identified it as phlegmatic hygrosis syndrome,and used Shegan Mahuang Decoction.By warming the lung and evaporating fluid,the lung can restore the function of dispersiveness.In the second case,Professor LAO identified it as liver depression and Qi stagnation,and used Banxia Xiexin Decoction.By soothing the liver and regulating Qi,balancing cold and heat,making the Qi movement normal,all symptoms were relieved.[Conclusion]Professor LAO focuses on the differentiation of external and internal injuries in the treatment of postinfective cough,emphasizes the combination of disease and syndrome differentiation,adds or subtracts drugs according to the pathological products of patients and the function of Zang-Fu organs,pays attention to diet care,and has achieved stable clinical efficacy,which is convenient for clinical application and promotion.

Syndrome and Treatment Rules of Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease Based on Modern Medical Cases / 中国实验方剂学杂志

ObjectiveTo explore the syndrome and treatment rules of traditional Chinese medicine （TCM） in treating chronic obstructive pulmonary disease （COPD） based on the medical literature and cases with the help of TCM inheritance support system platform （V2.5）， thus providing new ideas for TCM to treat COPD. MethodThe medical cases of TCM treating COPD were retrieved from China national knowledge infrastructure （CNKI）， Wanfang Database， and VIP China Science and Technology Journal Database. The medical cases that met the inclusion literature were collected in a new Word document， and then input into the TCM inheritance support system platform （V2.5） after data standardization. With the help of the algorithm carried by this software， the frequency statistics of "symptoms， syndrome types of TCM， Chinese medicine， and meridians of Chinese medicine" in the included COPD medical cases were performed， and the correlation analysis of the "prescription rules" in the included medical cases was carried out， thus excavating the potential core drug pairs and new prescriptions for the treatment of COPD. ResultA total of 103 articles were included with 126 medical cases and 131 diagnoses and treatments. According to statistics， the common symptoms of COPD were cough， expectoration， chest tightness， and asthma， and the common TCM syndromes included phlegm-heat obstructing lung， phlegm and blood stasis blocking lung， and lung-spleen Qi deficiency. The common TCM treatment methods included clearing heat and resolving phlegm， banking up earth to generate metal， and descending adverse and relieving dyspnea， among which the high-frequency Chinese medicines for the treatment of COPD were Pinelliae Rhizoma， Armeniacae Semen Amarum， Ephedrae Herba， Citri Reticulatae Pericarpium， and so on. The commonly used drug pairs included Asari Radix et Rhizoma-Pinelliae Rhizoma， Pinelliae Rhizoma-Schisandrae Chinensis Fructus-Glycyrrhizae Radix et Rhizoma， etc. Twelve new prescriptions for the treatment of COPD were found. ConclusionTCM believes that COPD is a lung disease formed by external evil， phlegm， blood stasis， and other pathological factors， with cough， phlegm， and asthma as the main symptoms. The main syndromes of COPD are phlegm-heat obstructing lung， phlegm and blood stasis blocking lung， and lung-spleen qi deficiency. "Strengthening the upright and dispelling evil" is the basic principle of the treatment COPD. In clinical， TCM methods with dispelling phlegm and removing blood stasis， and tonifying lung， spleen， and kidney should be adopted to treat COPD.

Analysis on Medication Rules of National Medical Masters in Treatment of Stomachache / 中国实验方剂学杂志

Objective: To analyze medication rules of national medical masters in the treatment of stomachache by data mining. Method: Prescriptions were collected from 9 works as well as the first batch of national medical masters' medical cases and prescriptions for stomachache recorded in CNKI. Then, Microsoft Excel 2016 was adopted for analyzing the frequencies, properties, flavors and meridian tropisms of herbs, the Apriori algorithm provided by SPSS Clementine 12.0 software was used to analyze association rules of the herbs, and factor analysis was conducted by SPSS 19.0 software. Result: A total of 175 prescriptions containing 230 herbs were selected. The top five herbs used in frequency ranking were Glycyrrhizae Radix et Rhizoma, Paeoniae Radix Alba, Pinelliae Rhizoma, Atractylodis Macrocephalae Rhizoma, Poria. The medical properties with high usage frequency were warm, mild and slight cold. The flavors were sweet, bitter and pungent. Meridian tropisms were spleen, stomach and lung. Herbs for regulating Qi, tonifying Qi and promoting digestion ranked top three according to the classification of efficacy. The association rules analysis showed that the highest confidence and support of the related drugs was Atractylodis Macrocephalae Rhizoma→Codonopsis Radix-Poria, which reflected treatment characteristics of national medical masters with Sijunzitang as the basic prescription for tonifying Qi. A total of 12 strongly association rules of 2-drug pairs were obtained by association rules, and the most commonly used of which was Paeoniae Radix Alba-Glycyrrhizae Radix et Rhizoma. Nine common factors were respectively extracted by factor analysis. Conclusion: Herbs used in the prescriptions of national medical masters for treatment of stomachache are often with the actions of regulating Qi, invigorating deficiency and benefiting Qi, in addition, Shaoyao Gancaotang is often used to generate Yin and relieve pain.

Deconstruction Study of the Experience of Famous Old Traditional Chinese Medicine Doctors of Jiangsu, Zhejiang and Shanghai in Applying Medicinal Paste / 世界科学技术-中医药现代化

Objective: To study the experience of famous old Traditional Chinese Medicine doctors of Jiangsu, Zhejiangand Shanghai in applying medicinal paste according to the deconstruction analysis of the medical cases formed by miningthe linked data of original cases on the basis of TCM features. Methods: To apply a deconstruction analysis to thesedoctors. medical cases with the quantifiable trend data on the data processing platform of Medcase. Results: This studycollected 472 medical visits, 250 pathogenesis elements, 400 therapies and 529 kinds of herbs. Conclusion: The medicinal pastes are applied by these famous doctors to treat commonly seen consumptive diseases, namely to intervenesub-health status. The chief core indications are lassitude, poor sleep, lumbar soreness and poor appetite; the relatedtongue and pulse conditions are thin or white tongue coating, red or pale tongue proper, and a thready or wiry pulse; thechief pathogenesis elements are deficiency of the liver and kidney, and deficiency of the spleen and kidney; thefrequently used herbs are Radix Astragali seu Hedysari, Rhizoma Atractylodis Macrocephalae, Poria, Radix Angelicae Sinensis, Radix Paeoniae, Radix Glycyrrhizae, Radix Rehmanniae Preparata, etc. The prescriptions for medicinal pastesare made by modifying several basic formulas including Sijunzi Decoction, Siwu Decoction, Bazhen Decoction, DangguiBuxue Decoction, Liuwei Dihuang Pills, and Shengmai Decoction. The common excipients for pastes are Ejiao, rockcandy, Guibanjiao, Lujiaojio, etc. The guide for making the pastes are combined therapies, such as regulating both qi andblood, tonifying both yin and yang, and treating both deficiency and excess.

Summarization of the Experience of Luteinized Unruptured Follicle Syndrome's Treatment by Professor TAN Yong / 浙江中医药大学学报

[Objective] This paper introduces the experience of Professor TAN Yong's treatment of the luteinized unruptured follicle syndrome(LUFS) with a view to provide references for the related study.[Methods]Through studying with Professor TAN, collecting and analyzing clinical case data, researching editorial book and articles. From the etiology, pathogenesis and drug selection of the LUFS, the clinical experience of the teacher was discussed, Professor TAN's academic characteristics on the treatment of LUFS were summarized, and a medical case was provided to support the idea.[Results]Professor TAN believes that the pathogenesis of this disease is mostly due to deficiency of the kidney Yin, the weak Yang qi, Yin and Yang conversion is unfavorable during intermenstrual period, combined with pathological factors such as liver depression, blood stasis, and phlegm dampness. Unsmooth running of Qi and blood, so that the follicular can not be discharged smoothly, the disease occurs. In the treatment of combination of Traditional Chinese Medicine(TCM) and western Medicine, in the intermenstrual period attach importance to the function of the heart and brain, to tonifying kidney and blood circulation as a method, the use of "Tonifying Kidney Stimulating Ovulation" medicine treatment, combined with western medicine, in the clinically achieved good results. The medical case was based on the "Tonifying kidney Stimulating Ovulation" medicine as the basis for the successful pregnancy after the treatment, which fully proved the above mentioned dialectical thinking and treatment experience. [Conclusion]It is worthwhile to learn and promote the treatment of LUFS with tonifying kidney and blood circulation therapy.

The Clinical Experience of Professor HE Ruoping in the Treatment of Perimenopausal Syndrome / 浙江中医药大学学报

[Objective] To summarize the academic views and clinical experience of Professor HE Ruoping in the treatment of peri menopausal syndrome by using traditional Chinese medicine. [Method] From the clinical treatment, collecting the clinical information of the teacher, research and discuss the traditional Chinese medicine academic ideas and clinical experience of teacher HE in the treatment of perimenopausal syndrome, to summarize the traditional Chinese medicine of perimenopausal syndrome in dialectical characteristic.And further explain the characteristics of the treatment of teacher HE through case analysis. [Result] Teacher HE thinks that the main pathogenesis of perimenopausal syndrome is the deficiency of kidney Yin, and divides the patients into stagnation of liver-qi type, Qi stagnation and blood stasis, disharmony between heart and kidney, heart and spleen deficiency type, yin-yang deficiency type, a total of five kinds of syndrome types, according to their clinical manifestation.When confronted with such patients, teacher HE often chooses Liuwei Dihuang Pills to tonify kidney-yin and relieve liver for smooth Qi, promoting qi to activate blood, restoring normal coordination between heart and kidney, invigorating heart and spleen, tonify both Yin and Yang, gives patients more grooming solution at the same time to adjust their physical and mental state as a whole, so the patients could receive remarkable effect and avoid the potential risks of hormone replacement therapy.The case in this article has obtained good treatment results. [Conclusion] Teacher HE treats perimenopause syndrome by tonifying kidney-yin and taking accompanied symptoms and signs into account meanwhile, which has significant clinical effect and the value of popularization and application.

Professor HAN Xinmin's Treatment of Pediatric Sigh / 浙江中医药大学学报

[Objective]The paper summarizes Professor HAN Xinmin's experiences on treating pediatric sigh by using Gualou Xiebai Banxia decoction.[Methods] By learning from Professor HAN Xinmin, recording the relevant cases and analyzing typical cases, to sum up the academic thoughts and effective prescription, as well as list one proved case. [Results] Professor HAN Xinmin holds that most children with sigh have syndromes of deficiency and excess. This is the case of Qi deficiency of the spleen and lung, the insufficiency of the chest Yang and with phlegm evil. Using Gualou Xiebai Banxia decoction with the method of clearing Yang Qi and removing phlegm and activating blood stasis can achieve a satisfactory clinical curative effect by treating based on syndrome differentiation. [Conclusion] Professor HAN Xinmin has unique clinical experience for treating pediatric sigh. Gualou Xiebai Banxia decoction has significant effect, which has the value of popularization and application.

CHENG Zhiqing’s Experience in Treating Chest Stuffiness and Pains by Soothing-liver Regulating Qi and Activating Stagnated Yang / 浙江中医药大学学报

Objective]To sum up Pro.CHENG Zhiqing’s clinical experience in treating coronary heart disease.[Method] By following and studying Pro. CHENG Zhiqing’s clinical experienced cases in treating coronary heart disease, Pro. CHENG Zhiqing’s academic viewpoints and characterizes were summed up from soothing liver and activating stagnated Yang, with one case for detailed explanation. [Result]Pro. CHENG obtains that liver-qi invasion and thoracic yang obstruction are both main traditional Chinese medicine(TCM) syndrome types. In clinical practice, Pro. CHENG emphasizes that the liver qi should be recuperated to treatment of heart diseases,and activating stagnated Yang be paid attention while removing blood stasis and eliminating the phlegm.The good curative effect relies on her ingenious flexible selection of traditional Chinese medicine,as verified by the cited case.[Conclusion] The methods of soothing liver and activating stagnated Yang have good clinical effect in treating coronary heart disease, which worthy of peer reference.

Clinical Experience of Professor SHEN Hong for Treating Ulcerative Colitis by Enema / 浙江中医药大学学报

Objective]To summarize professor SHEN Hong’s clinical experience in treating ulcerative colitis with enema prescription.[Method] By following the teacher clinic and sorting out the related cases, the author summarizes professor SHEN Hong’s academic experience of treatment of ulcerative colitis with enema prescription, and for proven cases. [Result]On the base of disease stage, Professor SHEN Hong uses the advantages of external therapy of Chinese medicine, and combines the syndrome differentiation and disease differentiation by the reference to the treatment of abscess,carbuncle. On the acute stage, he uses the elimination method to relieve heat and toxic material, cool blood and eliminate carbuncle. On the remission stage, he uses reinforcing method to support sore and drainage of pus and heal wound and promote tissue regeneration in case of recrudescence. Meantime, he focuses on the different locations of lesions by reasonable enema ways. The medication he uses is concise and the prescription changes flexibly with permitted addition and subtraction. The clinical curative effect is satisfactory. [Conclusion] Professor SHEN Hong’s experience is effective and worthy of inheritance and promotion.

"Pro. SUN Zhi's Experience of""Purge Stomach and Tonify Spleen""Treatment of Acupuncture on Type-2 Diabetes Mellitus" / 浙江中医药大学学报

[Objective] Analyze the academic thought ofpurge stomach and tonify spleentreatment used by Professor SUN Zhi in acupuncture on type-2 diabetes mellitus during his clinical experience.[Method] According to new recognition of type-2 diabetes mellitus pathogenesis, study of acupuncture theory, clinical manipulation, conclude acupuncture point choices and needling methods ofpurge stomach and tonify spleentreatment, studying its characteristics. [Result] Type-2 diabetes mellitus belonging toXiaokecategory which features excessive discharge of urine and persistent thirst in Chinese medicine, but their pathogenesis is not the same, Professor SUN Zhi based on years of clinical observation found that patients with type-2 diabetes mellitus commonly manifested obese, polyorexia and accompanied by fatigue, summarized asstrong stomach and weak spleen. Tonify the deficiency and purge sthenia, using acupuncture manipulation, regulating spleen and stomach function, by reducing method of acupuncture Zhongwan, Zusanli and Neiting to inhibt stomach and control appetite, reinforcing method of acupuncture Sanyinjiao, Taibai, Pishu to enhance the transport of the spleen, meaning purging stomach and tonifying spleen. This treatment of type-2 diabetes mellitus in clinic achieved good results. [Conclusion]Purge stomach and tonify spleentreatment offers a new way of acupuncture to treat diabetes, deserving further exploration, popularization and application.

Professor SHI Yanping's Experience of the Treatment of Adenomyosis / 浙江中医药大学学报

[Objective] To introduce the Professor SHI Yanping's experience in treating adenomyosis with traditional Chinese medicine. [Methods]Through clinical learning with the teacher and systematic reading literatures about adenomyosis, the author summarized the teacher 's academic thoughts and clinical treating experience of the disease from the etiology and pathogenesis,fundamental law of treatment ,and medication characteristics,and one proven case was presented respectively.[Result] Professor SHI thinks the basic pathogenesis of adenomyosis is deficiency of kidney and blood stasis, accompanied by phlegm dampness, the proof is vacuity, treatment should be staged in terms of different periods:non menses-paying attention to eliminating mass and strengthening the body resistance, creatingNei Yi Ting Fang;menses-paying attention to regulating qi and blood by warming drugs, makingXin Gui Zhi Tong Fang;and at the same time,we have to pay attention to the adjustment of life style.All those lead to a good clinical effect. [Conclusion] The rich experience of Professor SHI in treating this disease might be worthy of promotion and learning,which has a good effect on relieving the discomforts and improving the quality of life in patients.

The Introducion of Professor YE Jin's Experience in Treating Infantile Recurrent Abdominal Pain / 浙江中医药大学学报

[Objective]The paper was designed to introduce the Professor YE Jin's personal clinical experience which can provide an effective means for other pediatrician.[Method]By introducing the Professor YE Jin's personal clinical experience,we summarize the effective therapies about the infantile recurrent abdominal pain(RAP). [Result]According to the Professor YE Jin, the pathomechanism of RAP includes mainly cold stagnation, the indigestion, parasite and Qi stagnancy. RAP caused bycoldcan be treated from warming the middle-energizer and fending off the cold,RAP resulting from retention of food can be cured by removing the retention and invigorating the stomach, RAP incurred by ascaris can be cured by relieving ascariasis,expelling parasite and purgation simultaneously,and RAP resulting from Qi stagnation can be cured by soothing liver, regulating qi activity, rather than relieving pain merely. Based on the above-mentioned theory,she tends to use Liquorice and prefers Paeonia a lot in curing the disease, that is always effective in clinic as a result.The recurrence rate is also lower.One case was provided for verification.[Conclusion]Professor YE Jin thinks that warming the middle-energizer and fending off the cold, removing the retention and invigorating the stomach, the RAP can be improved the curative effect,and that can provide another idea for other clinicians.

Professor and National Physician Master GUO Chengjie's Malt Clinical Application Experience / 浙江中医药大学学报

[Objective] To summarize the clinical experience of the national physician master professor GUO Chengjie application of malt, provide reference for clinical application. [Methods] By following GUO Lao clinical practice study and consulting GUO Lao of previous clinical cases, collection, analysis, summarize the experiences of application of malt of GUO Lao and features, case example is given. [Results] Guo Lao clinical application of this product, FaGu and innovation, to create, dosage, many decoction is exquisite, in prescription compatibility, such as liver and qi, clearly purging liver and gall, disinhibiting dampness and relieving jaundice shall use raw product, lactation most appropriate for raw and fry, back to milk needs fry and large dosage, the food is fried with appropriate medium doses, good clinical results will often begot. [Conclusion] GUO Lao unique method of clinical application of malt, clinical each fine effect, is worth learning to imitate.

Relationship Between Syndromes and Prescriptions of Damp Disease: a Neural Network-based Study on Cases from Lin Zheng Zhi Nan Yi An Shi / 中国中医药信息杂志

Objective Taking medical cases in Lin Zheng Zhi Nan Yi An Shi as examples to analyze the network relationship between the syndromes and prescriptions through building a medical case model forecasting medication via artificial neural networks for the syndromes and prescriptions in medical cases. Methods The study screened medical cases in Lin Zheng Zhi Nan Yi An Shi, and standardized and entered the data with Python language programming. PyBrain module was used to build and train a network model. The MatPlotLib module drew the error curve and the predicted fit curve, and evaluated the sensitivity and specificity. NetworkX module realized the visual expression of the network relationship between the syndromes and prescriptions, and analyzed the medicine within the prescriptions and compatibility relationship and the relationship between the pathogenesis and pathology. Results The sensitivity of the constructed medical case network model was 96.15% and the specificity was 75.00%. The visual mapping of the network relationship between the syndromes and prescriptions and the analysis on single, single group, and multi-angle were realized. Conclusion Neural network is capable to simulate the relationship between syndromes and prescriptions of medical knowledge. The visual combination and manifestation of network can provide a feasible solution for the knowledge discovery in medical literature.

Diagnosis and Treatment Experience on Bile Reflux Gastritis of Professor / 浙江中医药大学学报

[Objective] To investigate professor SHAN Zhaowei's experience of diagnosing and treating bile reflux gastritis(BRG). [Method] The experience of Professor SHAN Zhaowei on recognition of etiology and pathogenesis, treatment principle, characteristics of prescription selection and administration of BRG is summarized and studied. Besides his academic ideas and clinical medication experience are shown with typical cases. [Result] In his view, emotional disorder is the most common etiology, and liver-stomach disharmony is the basic pathogenesis. He puts forward that we should pay attention to dispersing the stagnated liver Qi, regulating the stomach to lower the adverse flow of Qi when we treat it, and emphasizes the combination of disease differentiation and syndrome differentiation. Meanwhile, herbs of protecting gastric mucosa are compatibly used to improve the curative effect. And the case in this article has obtained good treatment results. [Conclusion] Pro. SHAN Zhaowei thinks that emotional regulation to patency for patients is very important. The dispersing the stagnated liver Qi, regulating the stomach and protecting gastric mucosa treatment proposed by SHAN Zhaowei is smart, simple and effective, which embodies the characteristic of his healing and MengHe Medicine.

A Preliminary Study on the San Jiao Theory of ZHENG Qin'an / 浙江中医药大学学报

[Objective] To guide the clinical application of Fuyang medicine through the study of San Jiao Theory of ZHENG Qin'an [Method] To study the foundation theory of ZHENG Qin'an and correlate the evidence with the concept of original yang, San Jiao, Emporer fire, Minister fire and middle earth. To explain the unity and inter-relation of San Jiao and the symptons of yang deficiency of San Jiao and the approach of the use of medicine with the support of case studies. [Result] Zheng Qin'an suggested that three Jiaos are of one Jiao. The yang of upper jiao is governed by Emperor fire while that of lower Jiao by Minister fire. The two fires are of one fire. The circulation of the two fires generates the middle earth. When the middle yang fails on circulating the upper and lower Jiaos cannot communicate. The root of original yang is the kidney which is nourished by the spleen. The unity of San Jiao, the use of lower yang as the root of upper and middle yang and the use of the circulation and root nourishing action of middle yang are the keys to application of medicine. [Conclusion] The use of medicine of ZHENG strongly adhered to the qi circulation of San Jiao. It showed to the later generations a simple but comprehensive thought of Chinese medicine. It was an important guidance for the use of Fuyang medicine.