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Background: Spinal anesthesia is popular, simple and well accepted reliable technique for below umbilicus surgery. It is frequently used for lower segment section because of its rapid onset, a dense neural block, avoidance of risk of airway, little risk of local anesthetic toxicity and minimal transfer of drug to the fetus, as well as little risk of failure of block. Objectives of this study was to compare incidence and severity of hypotension, dose requirement of mephentermine and maternal bradycardia, shivering, nausea, vomiting. Methods: ASA grade I, II parturients posted for elective cesarean section were randomly allocated in two study groups of 55 each to receive either preload or co-load with Ringers lactate solution, blood pressure, heart rate, mephentermine requirement and other outcomes recorded at regular interval. Results: Hypotension was observed significantly less in co-loading group (37.18%) than preloading group (61.81%). Mean vasopressor requirement was also significantly more in preload group. Heart rate change, nausea, vomiting and fetal outcome remained same across both the groups. Conclusions: Co-loading with crystalloids is more effective strategy than preloading in prevention of spinal induced hypotension. We can save valuable time given for preloading in case of emergency caesarean sections.
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@#In the complications of dental implant treatment, the mechanical complications, such as central screw breakage, are often complex and serious. This article analyzes factors that affect the loosening of the central screw. Understanding relevant risk factors can prompt doctors to take corresponding strategies to reduce the possibility of complications in clinical operations. After encountering broken cases, this paper also gives some ideas and methods of treatment, and finally summarizes clinical suggestions for preventing the central screw fracture.
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Porous titanium alloy scaffold was widely used in treating bone defect caused by traumatic injury and osteomyelitis, which was incapable of self-healing. The implantation of scaffold produced stress shielding thereby forming osteolysis. The objective of this study was to analysis trabecular morphological features of osseointegrated bone. 14 New Zealand rabbits were divided into two groups, surgery group and healthy control group. 7 rabbits in surgery group were selected to perform 3D printed porous titanium alloy scaffold implantation surgery with preload at the defect of femoral condyle for osseointegration. The other 7 rabbits in control group were feed free. After 90 days healing, femoral condyles were extracted to perform micro-CT scanning with hydroxyapatite calibration phantom. Mean bone mineral density (BMD), bone volume fraction (BV/TV), BS/TV (bone surface area ratio), Tb.Th (thickness of trabeculae), Tb.N (number of trabeculae), Tb.Sp (trabecular separation) and DA (degree of anisotropy) were calculated from micro-CT images. The results revealed that osseointegration inside and at the surface of scaffolds worked well from grey values of micro-CT images. After 12 weeks healing, mean bone mineral densities (BMD) in surgery group and healthy control group were calculated as 800±20mg/cm3 and 980±90mg/cm3, respectively. This revealed that the strength of trabeculae in surgery group might lower than that in the healthy group. Trabecular morphological parameters test showed that trabecular morphological parameters at the surface of scaffolds in the surgery group deteriorated significantly. It was found from micro-CT images that ingrowth bone was filled with pores of scaffold. Overall, the effect of osseointegration was promoted through the change of mechanical micro-environment in the scaffold region. Overall, preload could improve osseointegration effect in the long-term after surgery. However, the trabecular morphology in the surgery group was deteriorated, which might bring secondary fracture risk again.
La malla de aleación de titanio poroso se usó ampliamente en el tratamiento de defectos óseos causados por lesiones traumáticas y osteomielitis. El implante de la malla generó una protección contra el estrés, formando así osteolisis. El objetivo de este estudio fue analizar las características morfológicas trabeculares del hueso osteointegrado. Se dividieron 14 conejos (Neozelandeses) en dos grupos, grupo cirugía y grupo control saludable. Se seleccionaron 7 conejos en el grupo de cirugía para realizar una implantación de mallas de aleación de titanio poroso, impresas en 3D con precarga en el defecto del cóndilo femoral para la osteointegración. Los 7 conejos restantes del grupo control se mantuvieron sin alimentación. Después de 90 días de curación, se extrajeron los cóndilos femorales para realizar una exploración por micro-CT con un espectro de calibración de hidroxiapatita. Se calcularon a partir de imágenes de micro-CTDensidad mineral ósea media (DMO), fracción de volumen óseo (BV / TV), BS / TV (relación de área de superficie ósea), Tb.Th (espesor de trabéculas), Tb.N (número de trabéculas), Tb.Sp (trabecular separación) y DA (grado de anisotropía). Los resultados revelaron que la osteointegración dentro y en la superficie de los andamios funcionó bien a partir de los valores grises de las imágenes de micro-CT. Después de 12 semanas de curación, las densidades medias de minerales óseos (DMO) en el grupo cirugía y en el grupo control sano se calcularon como 800 ± 20 mg/cm3 y 980 ± 90 mg/cm3, respectivamente. Esto reveló que la fuerza de las trabéculas en el grupo de cirugía podría ser menor que la del grupo sano. La prueba de parámetros morfológicos trabeculares mostró que en el grupo de cirugía, la superficie de las mallas, se deterioraron significativamente. Se descubrió a partir de imágenes de microCT que el hueso en crecimiento estaba lleno de poros de andamio. En general, el efecto de la osteointegración se promovió mediante el cambio del microambiente mecánico en la región de la malla. En general, la precarga podría mejorar el efecto de osteointegración a largo plazo después de la cirugía. Sin embargo, la morfología trabecular en el grupo de cirugía se deterioró, lo que podría traer un nuevo riesgo de fractura secundaria.
الموضوعات
Animals , Rabbits , Bone Diseases/surgery , Osseointegration/physiology , Tissue Scaffolds/chemistry , Printing, Three-Dimensional , Prostheses and Implants , Titanium/chemistry , Porosity , Alloys , X-Ray Microtomography , Femur/surgeryالملخص
Abstract Introduction: Speckle-tracking echocardiography has shown its usefulness in the evaluation of the right ventricle (RV) in healthy subjects and in pulmonary hypertension. It is unknown whether this technique could be sensitive to assess healthy RV with increases in preload. Methods: Consecutive subjects were studied without evidence of cardiopulmonary disease. They underwent speckle-tracking echocardiography in General Electric Vivid 7® equipment. The "segmental longitudinal strain" (SLS) and "global longitudinal strain" (GLS) of the RV was determined at rest and with an increase in the preload through elevation the legs to 45°. Results: We analyzed 31 subjects, 16 men and 15 women, aged 16-53 years, in which were measured SLS and GLS. Basal of the RV free wall: —29.1 ± 3.3 versus −32.7 ± 5.5%, p = 0.0002. Mid of the RV free wall: —28.6 ± 6.4 versus —31.5 ± 4.9 %, p = 0.001. Apical of the free wall of the RV: —21.9 ± 6.5 versus —23.3 ± 6.1 %, p = 0.118. Basal inferoseptum: —19.40 ± 3.2 versus —18.9 ± 3.0 %, p = 0.204. Mid inferoseptum: —19.3 ± 3.2 versus —19 ± 3.1 %, p = 0.249. Apical septum: —17.1 ± 5.1 versus —17 ± 5.4 %, p = 0.457. GLS of the RV: —23.06 ± 3.4 versus —24.5 ± 2.9 %, p = 0.002. ICC: 0.773, 95 % CI: 0.534-0.890, p < 0.001. Conclusions: This method was sensitive to detect differences in the GLS and SLS basal and mid of the RV free wall.
Resumen Introducción: La ecocardiografía speckle-tracking (EST) ha mostrado su utilidad en la evaluación del ventrículo derecho (VD) en sujetos sanos y en hipertensión pulmonar. Se desconoce si esta técnica es sensible para evaluar el VD en sujetos sanos con aumento en la precarga. Método: Se evaluaron sujetos consecutivos sin evidencia de enfermedad cardiopulmonar. Se realizó EST con equipo General Electric Vivid 7®. La deformación longitudinal segmentaria (DLS) y la deformación longitudinal global (DLG) del VD se determinaron en reposo y con incremento en la precarga mediante la elevación de las piernas a 45°. Resultados: Analizamos 31 sujetos, 16 hombres y 15 mujeres. Edad: 16-53 años. Basal de la pared libre del VD: —29.1 ± 3.3 vs. —32.7 ± 5.5%, p = 0.0002. Medio de la pared libre del VD: —28.6 ± 6.4 vs. —31.5 ± 4.9%, p = 0.001. Apical de la pared libre del VD: —21.9 ± 6.5 vs. —23.3 ± 6.1, p = 0.118. Basal septum inferior: —19.40 ± 3.2 vs. —18.9 ± 3.0%, p = 0.204. Medio septum inferior: —19.3 ± 3.2 vs. —19 ± 3.1%, p = 0.249. Apical septal −17.1% ± 5.1 vs. −17 ± 5.4, p = 0.457. DLG del VD: —23.06 ± 3.4 vs. —24.5 ± 2.9%, p = 0.002. CCI: 0.773, IC 95%: 0.534-0.890, p < 0.001. Conclusiones: El método fue sensible para detectar diferencias en la DLG y DLS basal y media de la pared libre del VD.
الموضوعات
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Echocardiography/methods , Ventricular Function, Right , Heart Ventricles/diagnostic imaging , Patient Positioning , Healthy Volunteers , Legالملخص
Cardiac arrest is one of the leading causes of death all over the world. Despite the progress in the researches of pathopgenesis and management of cardiopulmonary resuscitation,the survival rate of patients with cardiac arrest has remained disappointingly low over the past two decades with only about 7%. On the other hand, in the past decades researchs about CPR mainly focus on the quality of compression. It is largely unknown the relation of preload and flow during cardiac resuscitation, evidence to augment preload during CPR may be one of futher direction to improve the outcome of cardiac arrest patients.
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Bowel obstruction is one of the common acuteabdominal diseases in surgery. The primary task of itstreatment is to replace the effective circulating blood volumelost caused by loss of digestive juice and increased exudationof inflammation through fluid therapy,and stabilize thehemodynamic state of patients. Therefore,optimizing thetiming,amount and composition of fluid therapy according tothe pathophysiological characteristics of fluid loss in patientswith bowel obstruction,and evaluating the effect of fluidtherapy scientifically and reasonably by the cardiac preload,tissue perfusion and oxygen metabolism are the keys to improve fluid therapy for bowel obstruction.
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PURPOSE: The purpose of this finite element analysis study is to introduce the novel Lock screw system and analyze its mechanical property to see if it can prevent abutment screw loosening. MATERIALS AND METHODS: The Lock screw is a component tightened on the inside of the implant abutment which applies compressive force to the abutment screw head. To investigate the effect, modeling was done using CAD program and it was analyzed by finite element analysis under various load conditions. First, the preload was measured according to the tightening torque of the abutment screw then it was compared with the theoretical value to verify the analytical model. The validated analytical model was then divided into those with no external load and those with 178 N, and the tightening torque of the lock screw was changed to 10, 20, 30 Ncm respectively to examine the property of stress distribution on the implant components. RESULTS: Using Lock screw under various loading conditions did not produce equivalent stresses beyond the yield strength of the implant components. In addition, the axial load was increased at the abutment-abutment screw interface. CONCLUSION: The use of Lock screw does not exert excessive stress on the implant components and may increase the frictional force between the abutment-abutment screw interface, thus it is considered to prevent loosening of the abutment screw.
الموضوعات
Finite Element Analysis , Friction , Head , Torqueالملخص
The introduction of left ventricular assist device (LVAD) has improved survival rates for patients with end-stage heart failure. Two categories of VADs exist: one generates pulsatile flow and the other produces nonpulsatile continuous flow. Survival is better for patients with continuous-flow LVADs. With improved survival, more of such patients now present for noncardiac surgery (NCS). This review, written for the general anesthesiologists, addresses the perioperative considerations when the patient undergoes NCS. For best outcomes, a multidisciplinary approach is essential in perioperative management of the patient.
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Resumen: Las Interacciones Cardiopulmonares (ICP) corresponden al conjunto de interrelaciones entre el sis tema respiratorio y el cardiovascular, durante el ciclo respiratorio y cardíaco. Estas interacciones varían dependiendo de si el paciente se encuentra en ventilación espontánea o mecánica, afectando en distintos grados la precarga y postcarga, tanto del ventrículo derecho e izquierdo. El entender estas interacciones, resulta esencial al momento de manejar pacientes críticamente enfermos, en donde las manipulaciones de la precarga y postcarga, son de especial importancia al momento de optimizar el débito cardíaco y la entrega de oxígeno a los tejidos. En este artículo se presentan los principios fisiológicos que permiten entender las interacciones cardiopulmonares en ventilación espontánea y en ventilación mecánica, aplicadas a situaciones clínicas específicas, lo que nos ayudará a utilizarlas como herramientas en el manejo de los pacientes.
Abstract: Cardiopulmonary Interactions (CPI) refer to the interplay between the respiratory and cardiovascu lar systems during the respiratory and cardiac cycle. These interactions vary depending on whether the patient is in spontaneous or mechanical ventilation and affect the preload and afterload of both ventricles at different levels. Understanding CPI is essential to the management of critically ill pa tients, where preload and afterload manipulations are specialy important to optimize cardiac output and oxygen delivery to the periphery. The present article reviews the physiological principles required to understand CPI in patients both in spontaneous and mechanical ventilation using specific clinical scenarios to facilitate its use as part of day to day clinical practice.
الموضوعات
Humans , Respiration, Artificial , Respiratory Physiological Phenomena , Cardiovascular Physiological Phenomena , Critical Illness , Heart/physiology , Heart/physiopathology , Lung/physiology , Lung/physiopathologyالملخص
BACKGROUND AND OBJECTIVE@#Stroke volume variation (SVV) has high sensitivity and specificity in predicting fluid responsiveness. However, sinus rhythm (SR) and controlled mechanical ventilation (CV) are mandatory for their application. Several studies suggest a limited applicability of SVV in intensive care unit (ICU) patients. We hypothesized that the applicability of SVV might be different over time and within certain subgroups of ICU patients. Therefore, we analysed the prevalence of SR and CV in ICU patients during the first 24 h of PiCCO-monitoring (primary endpoint) and during the total ICU stay. We also investigated the applicability of SVV in the subgroups of patients with sepsis, cirrhosis, and acute pancreatitis.@*METHODS@#The prevalence of SR and CV was documented immediately before 1241 thermodilution measurements in 88 patients.@*RESULTS@#In all measurements, SVV was applicable in about 24%. However, the applicability of SVV was time-dependent: the prevalence of both SR and CV was higher during the first 24 h compared to measurements thereafter (36.1% vs. 21.9%; P<0.001). Within different subgroups, the applicability during the first 24 h of monitoring ranged between 0% in acute pancreatitis, 25.5% in liver failure, and 48.9% in patients without pancreatitis, liver failure, pneumonia or sepsis.@*CONCLUSIONS@#The applicability of SVV in a predominantly medical ICU is only about 25%-35%. The prevalence of both mandatory criteria decreases over time during the ICU stay. Furthermore, the applicability is particularly low in patients with acute pancreatitis and liver failure.
الموضوعات
Adult , Aged , Female , Humans , Male , Middle Aged , Analysis of Variance , Blood Pressure , Fluid Therapy , Hemodynamics , Intensive Care Units , Liver Failure , Therapeutics , Monitoring, Physiologic , Methods , Pancreatitis , Therapeutics , Prospective Studies , Respiration, Artificial , Sepsis , Therapeutics , Stroke Volumeالملخص
To investigate the influence of the preload and supporting stiffness on the hearing compensation performance of round window stimulation, a coupling finite model composed of a human ear, an actuator and a support was established. This model was constructed based on a complete set of micro-computed tomography (Micro-CT) images of a healthy adult's right ear by reverse engineering technology. The validity of the model was verified by comparing the model's calculated results with experimental data. Based on this model, we applied different amplitude preloads on the actuator, and changed the support's stiffness. Then, the influences of the actuator's preload and the support's stiffness were analyzed by comparing the corresponding displacements of the basilar membrane. The results show that after applying a preload on the actuator, its hearing compensation performance was increased at the middle and high frequencies, but was deteriorated at low frequencies; besides, compared with using the fascia as the actuator's support in clinical practice, utilizing the titanium alloy to fabricate the support would enhance the hearing compensation performance of the round window stimulation in the whole frequency range.
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The conventional analysis and approach to the physiology of the fluid responsiveness has traditionally been focused mainly on the physiology of heart-lung interactions, and on reviews of the technical, methodological, and epidemiological aspects of the dynamic parameters, which are translated into simple algorithms to assess fluid responsiveness and to guide fluid therapy.However, fundamental features of the dynamics of the peripheral circulation, heart-vasculature interaction, and blood volume distribution, are overlooked and sometimes not accounted for, motivating misconceptions about the cardiovascular system's response to fluid administration and fluid management, such as equating fluid loading with cardiac preload, a predictable interpretation whenever Starling's ventricular function curve is analyzed in isolation. This paper reexamines fluid responsiveness' rationale offering a broadened perspective on the circulatory phenomena involved in the physiological interaction between BV, cardiac preload and output, and stroke volume variation. Finally, implications relevant in physiological and clinical terms are discussed.
El análisis convencional y abordaje actual de la fisiología de la "respuesta a fluidos" (RF) ha estado focalizada principalmente sobre la fisiología de la interacción cardiopulmonar, y sobre aspectos técnicos, metodológicos y, epidemiológicos de los parámetros dinámicos, los cuales son traducidos en algoritmos simplificados para evaluar la RF y guiar la fluidoterapia. Sin embargo, aspectos fundamentales de la dinámica de la circulación periférica, el acoplamiento entre el corazón y la vasculatura, y la distribución del volumen sanguíneo son frecuentemente omitidos, motivando mal interpretaciones sobre la respuesta del sistema cardiovascular a la administración de fluidos, tal como equiparar la carga de fluidos con la precarga ventricular, una consecuencia predecible al interpretar la curva de función ventricular (Starling) de forma aislada. Así, esta revisión reexamina la rationale de la RF, ofreciendo una perspectiva ampliada sobre aquellos fenómenos circulatorios implicados en la interacción entre el volumen sanguíneo, la precarga ventricular, el gasto cardíaco y la variación del volumen sistólico. Finalmente, se analizarán las implicancias prácticas y conceptuales.
الموضوعات
Humans , Fluid Therapy , Hemodynamics/physiology , Stroke Volume , Blood Pressure , Blood Volume , Central Venous Pressure , Homeostasisالملخص
Introduction: Central venous pressure (CVP) measurement is essential in the management of certain clinical situations, including cardiac failure, volume overload and sepsis. CVP measurement requires catheterization of the central vein which is invasive and may lead to complications. The aim of this study was to evaluate the accuracy of measurement of CVP using a new noninvasive method based on near infrared spectroscopy (NIRS) in a group of cardiac surgical Intensive Care Unit (ICU) patients. Methodology: Thirty patients in cardiac surgical ICU were enrolled in the study who had an in situ central venous catheter (CVC). Sixty measurements were recorded in 1 h for each patient. A total of 1800 values were compared between noninvasive CVP (CVPn) obtained from Mespere VENUS 2000 CVP system and invasive CVP (CVPi) obtained from CVC. Results: Strong positive correlation was found between CVPi and CVPn (R = 0.9272, P < 0.0001). Linear regression equation ‑ CVPi = 0.5404 + 0.8875 × CVPn (r2 = 0.86, P < 0.001), Bland–Altman bias plots showed mean difference ± standard deviation and limits of agreement: −0.31 ± 1.36 and − 2.99 to + 2.37 (CVPi–CVPn). Conclusion: Noninvasive assessment of the CVP based on NIRS yields readings consistently close to those measured invasively. CVPn may be a clinically useful substitute for CVPi measurements with an advantage of being simple and continuous. It is a promising tool for early management of acute state wherein knowledge of CVP is helpful.
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Injection pain of propofol remains a common clinical problem. Previous studies demonstrated that propofol injection pain was alleviated by applying nitroglycerin ointment to the skin of injection site, which inspires us to test whether venous vasodilation induced by fluid preload could alleviate the pain. Different types or volumes of fluid preload were compared. 200 ASA I-II adult patients were randomly assigned to five groups of 40 each. A 20 G cannula was established on the dorsum or wrist of the hand. When fluid preload given with Plasma-Lyte A 100 mL (P100 group), 250 mL (P250 group), 500 mL (P500 group), 0.9% saline 500 mL (N500 group) or Gelofusine 500 mL (G500 group) was completed within 30 min, respectively, Propofol (0.5 mg/kg, 1%) was injected at a rate of 0.5 mL/s. A blind investigator assessed the pain using a four-point scale. Incidence of pain in P100, P250, and P500 groups was 87.5%, 57.5% and 35%, respectively (P<0.05). The median pain intensity score was significantly lower in P500 group than that in P250 and P100 groups (P<0.05 and P<0.01, respectively). Comparison of the effect of different types of solution preload indicated that the highest incidence of pain was in N500 group (62.5%) (N500 vs. P500, P=0.014; N500 vs. G500, P=0.007). The median pain intensity score in N500 group was higher than that in P500 group (P<0.05) and G500 group (P<0.05). There was no significant difference between P500 and G500 groups. It is suggested that Plasma-Lyte A or Gelofusine preload with 500 mL before propofol injection is effective in alleviating propofol-induced pain.
الموضوعات
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Electrolytes , Therapeutic Uses , Injections, Intravenous , Methods , Pain , Drug Therapy , Plasma Substitutes , Therapeutic Uses , Polygeline , Therapeutic Uses , Propofolالملخص
Background: Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim of our study was to assess the effect of tidal volume (V T) on PPV and SVV in the context of normal and reduced lung compliance in a piglet model. Material and method: Twenty large-white piglets (5.2 ± 0.4 kg) were anesthetized, paralyzed and monitored with pulse contour analysis. PPV and SVV were recorded during mechanical ventilation with a V T of 6 and 12 mL/kg (low and high V T, respectively), both before and after tracheal instillation of polysorbate 20. Results: Before acute lung injury (ALI) induction, modifications of V T did not significantly change PPV and SVV readings. After ALI, PPV and SVV were significantly greater during ventilation with a high V T compared to a low V T (PPV increased from 8.9 ± 1.2 to 12.4 ± 1.1%, and SVV from 8.5 ± 1.0 to 12.7 ± 1.2%, both P < 0.01). Conclusions: This study found that a high V T and reduced lung compliance due to ALI increase preload dynamic tests, with a greater influence of the latter. In subjects with ALI, lung compliance should be considered when interpreting the preload dynamic tests.
Introducción: Test dinámicos de precarga, variación de presión de pulso (PPV) y variación de volumen sistólico (SVV) han emergido como herramientas poderosas para predecir respuesta a la administración de fluidos. Actualmente la influencia de factores distintos a la precarga en la determinación de los test dinámicos de precarga es pobremente conocida en pediatría. Nuestro objetivo fue medir el efecto del volumen tidal (V T) sobre PPV y SVV en un contexto de compliance pulmonar normal y disminuida en un modelo porcino. Material y método: Veinte cerditos Large-White anestesiados y paralizados (5,2 ± 0,4 kg). PPV y SVV fueron medidos por análisis de contorno de pulso durante ventilación con V T de 6 y 12 mL/kg (V T bajo y alto, respectivamente), ambos previo y posterior a lesión pulmonar aguda (ALI) químicamente inducida con instilación traqueal de polisorbato 20. Resultados: Previo a inducción de ALI, PPV y SVV no tuvieron cambios significativos al modificar el V T. Sin embargo, después de ALI, PPV y SVV fueron significativamente mayores durante ventilación con V T alto, respecto a V T bajo (PPV aumentó de 8,9 ± 1,2 a 12,4 ± 1,1%, y SVV de 8,5 ± 1,0 a 12,7 ± 1,2%, ambos P < 0,01). Conclusiones: Este estudio encontró que un V T alto y una compliance pulmonar disminuida debido a ALI incrementan los test dinámicos de precarga, con una mayor influencia de esta última. En sujetos con ALI la compliance pulmonar debiera ser considerada al interpretar los test dinámicos de precarga.
الموضوعات
Animals , Tidal Volume/physiology , Lung Compliance/physiology , Acute Lung Injury/physiopathology , Fluid Therapy/methods , Respiration, Artificial/methods , Stroke Volume/physiology , Swine , Blood Pressure/physiology , Disease Models, Animalالملخص
Objective To investigate the impact of preload fasting and meal replacement in patients with metabolic syndrome.Methods A total of 92 subjects with metabolic syndrome were enrolled in the study.They were assigned into the preload fasting group (PFG),the meal replacement group (MRG),and the control group (CG) for 12-weeks intervention.Special dietary with 100 kcal was provided 30 min before each meal in the PFG,and while in the MRG the same dietary was taken just before each meal and the amount of meal was reduced appropriately.The subjects in CG took meals as usual.Body mass index,waist circumference,and insulin resistance were assessed.Satiety situation was investigated by the scale.Results After 12 weeks,improvement were found in fasting insulin(-3.29 mU/L) and waist circumference (-4.04 cm) in the PFG and significant difference was shown compared to the CG (P＜0.05).Satiety index in the PFG was the most significant among the three group.Conclusion Preload fasting is helpful in improving insulin resistance,reducing waist circumference,and enhancing satiety.
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PURPOSE: This study evaluated the influence of abutment materials on the stability of the implant-abutment joint in internal conical connection type implant systems. MATERIALS AND METHODS: Internal conical connection type implants, cement-retained abutments, and tungsten carbide-coated abutment screws were used. The abutments were fabricated with commercially pure grade 3 titanium (group T3), commercially pure grade 4 titanium (group T4), or Ti-6Al-4V (group TA) (n=5, each). In order to assess the amount of settlement after abutment fixation, a 30-Ncm tightening torque was applied, then the change in length before and after tightening the abutment screw was measured, and the preload exerted was recorded. The compressive bending strength was measured under the ISO14801 conditions. In order to determine whether there were significant changes in settlement, preload, and compressive bending strength before and after abutment fixation depending on abutment materials, one-way ANOVA and Tukey's HSD post-hoc test was performed. RESULTS: Group TA exhibited the smallest mean change in the combined length of the implant and abutment before and after fixation, and no difference was observed between groups T3 and T4 (P>.05). Group TA exhibited the highest preload and compressive bending strength values, followed by T4, then T3 (P<.001). CONCLUSION: The abutment material can influence the stability of the interface in internal conical connection type implant systems. The strength of the abutment material was inversely correlated with settlement, and positively correlated with compressive bending strength. Preload was inversely proportional to the frictional coefficient of the abutment material.
الموضوعات
Friction , Joints , Titanium , Torque , Tungstenالملخص
Introducción: el uso de vasoconstrictores puede afectar la capacidad de predecir la respuesta a volumen de los índices dinámicos. Objetivo: analizar los efectos del tono vasomotor aumentado sobre los índices dinámicos en un modelo de hemorragia. Métodos: se estudiaron 12 conejos durante normovolemia, luego de extracción de 20% de la volemia (HEM), durante la infusión de fenilefrina (FEN) y luego de la reposición con hidroxietilalmidón (HEA). Se midieron la presión (PAo) y flujo de la aorta (FAo) infradiafragmática, las presiones venosa central y ventricular izquierda, permitiendo estimar la variación de la presión arterial de pulso (VPP), del volumen sistólico (VVS) y la presión diastólica final del ventrículo izquierdo (PDFVI). Se monitorizó la pulsioximetría obteniendo la variación de la onda de pulso oximétrica (VOP) y la variación del índice pletismográfico (VIP). El tono vasomotor fue estimado mediante la resistencia vascular total (RVT=PAo/FAo) y la complacencia (C=SV/PAo pulso). Resultados: durante HEM todos los índices dinámicos aumentaron (p<0,05). La FEN determinó un descenso del FAo (p<0,05) y un aumento del tono vasomotor (p<0,05), seudonormalizando los índices dinámicos. El HEA normalizó el FAo y los índices dinámicos. La PDFVI no se modificó. Hubo correlación significativa entre la VVS y la VPP, VOP y la VIP durante N, HEM y HEA (sin fenilefrina), no habiendo correlación durante la infusión de fenilefrina. Conclusiones: la fenilefrina redujo los índices dinámicos enmascarando la pérdida de volumen posiblemente por el aumento del tono vasomotor. Este debería considerarse durante la optimización de la reposición con fluidos.
Introduction: the use of de vasoconstrictors may affect the ability to predict fluid responsiveness of dynamic indicators. Objective: to analyze the effects of an increased vasomotor tone on dynamic indicators in a model of hemorrhage. Methods: twelve rabbits were studied during normovolemia, after withdrawal of 20% of blood volume (HEM), during phenylephrine infusion (PHE) and after replacement with hydroxyethyl starch (HES). Measurements of blood pressure and flow of infradiaphragmatic aorta (AoP - AoF), central venous (CVP) and left ventricular (LVP) were performed, thus allowing to estimate the variation of pulse arterial pressure (PAP), of sistolic volumen (SVV) and end-distolic pressure of the left ventricle (LVEDP). Pulse oximetry was monitored to obtain the pulse oximetry wave variation (POV) and the plethysmographic variability index (PVI). Vasomotor tone was estimated by calculating the total vascular resistance (TVR=AoP/AoF) and compliance (C=SV/AoP pulse). Results: during HEM there was an increase in all dynamic indicators (p<0.05). PHE determined a decrease in the AoF (p<0.05) and an increase in the vasomotor tone (p<0.05), resulting in a pseudonormalization of the dynamic indicators. The HES normalized the AoF and the dynamic indicators. LVEDP was not modified. There was a significant correlation between the SVV and the PAP, POV and the PVI during N, HEM and HES (without phenylephrine); there was no correlation during phenylephrine infusion. Conclusions: phenylephrine reduced the dynamic indicators and concealed the volume deficit probably due to an increase of vasomotor tone. This should be taken into account during optimization of fluid replacement.
Introdução: o uso de vasoconstritores pode afetar a capacidade de predizer a resposta a volume dos índices dinâmicos. Objetivo: analisar os efeitos do tônus vasomotor aumentado sobre os índices dinâmicos em um modelo de hemorragia. Métodos: estudaram-se 12 coelhos durante normovolemia, após a extração de 20% da volemia (HEM), durante a infusão de fenilefrina (FEN) e logo após a reposição com hidroxietilalmidon (HEA). Mediram-se a pressão (PAo) e o fluxo da aorta (FAo) infradiafragmatica, as pressões venosa central e ventricular esquerda (VI), permitindo estimar a variação da pressão arterial do pulso (VPP), do volume sistólico (VVS) e a pressão diastólica final do VI (PDFVI). Monitorizou-se a oximetria de pulso obtendo a variação da onda de pulso oximetrica (VOP) e a variação do índice pletismografico (VIP). O tônus vasomotor foi estimado mediante a resistência vascular total (RTV=PAo/FAo) e a complacência (C=SV/PAo pulso). Resultados: durante HEM todos os índices dinâmicos aumentaram (p<0.05). A FEN determinou um descenso do FAo (p<0.05) e um aumento do tônus vasomotor (p<0.05), pseudonormalizando os índices dinâmicos. O HEA normalizou o FAo e os índices dinâmicos. O HEA normalizou o FAo e os índices dinâmicos. A PDFVI não se modificou. Houve correlação significativa entre VVS e a VPP,VOP e a VIP durante N, HEM e HEA (sem fenilefrina), não havendo correlação durante a infusão de fenilefrina. Conclusões: a fenilefrina diminui os índices dinâmicos mascarando a perda do volume possivelmente pelo aumento do tônus vasomotor. Este deveria considerar- se durante a otimização da reposição com fluidos.
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Introduction : The mechanical aspects of tightening screws over implants are important to ensure a successful prosthetic rehabilitation. Screw loosening is a common problem that can be avoided with passive adaptation of the components and an increased tensile force developed in the screw, a preload. Objective: This in vitro study evaluated the effect on preload of a carbon lubricant deposited on the surface of titanium alloy prosthetic screws: conventional Ti6Al4V and surface enhanced. Material and methods: Conventional titanium alloy prosthetic (n = 7) and carbon coating surface enhanced screws (n = 7) were compared. Each prosthetic screw supporting a metallic UCLA over an implant was tightened with the manufacturers recommended torque of 32 N.cm. The removal torque values, recorded for ten consecutive cycles of tightening and removal, were used to estimate the preload. Implant blocks were then sectioned and the interfaces were observed by light microscopy.Results: The lowest removal torque, and consequently the highest preload values, was achieved for the lubricated group in most cycles. The contacts between threads were located at the coronal aspect of all observed screw mating threads.Conclusion: Data indicate that the lower coefficient of friction of a carbon lubricant can generate higher preload. The machining precision observed produced the adaptation and regular contact interfaces.
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Próteses implantossuportadas estão sujeitas a diversos tipos de falhas, sendo o afrouxamento do parafuso de retenção a complicação mais frequente, devido à perda da pré-carga inicial. A perda da pré-carga pode ser influenciada por fatores como incidência de cargas oclusais impróprias, diferentes tipos de conexões do sistema implante/prótese e desajustes entre a coroa e o implante. Sendo assim, este estudo teve como objetivo avaliar a manutenção da pré-carga de parafusos de retenção de titânio e a desadaptação vertical de coroas protéticas parafusadas, antes e após a ciclagem mecânica. Para isso, três tipos de conexões implante/pilar foram utilizados: implantes de conexão interna híbrida com pilar do tipo esteticone (grupo CIE); implantes de conexão externa com pilar o tipo esteticone (grupo CEE); e implantes de conexão externa com pilar UCLA (grupo CEU). Para cada grupo, foram confeccionadas 10 coroas metálicas fundidas em liga de CoCrMo para a composição final dos corpos-de-prova. Os parafusos de retenção protéticos receberam torque de 20N.cm nos grupos CIE e CEE e 30N.cm no grupo CEU, e, após três minutos, foi mensurado o valor de destorque inicial, com o auxílio de um torquímetro analógico. Após essa avaliação inicial, as coroas receberam novamente o torque recomendado e foram submetidas ao ensaio de ciclagem mecânica, com carga oblíqua (30°) de 130N ± 10N, a 2Hz de freqüência, totalizando 1x106 ciclos. Após a ciclagem, foi mensurado o destorque final. Além disso, antes e depois da ciclagem mecânica, foi realizada a verificação da adaptação vertical das coroas por meio de um estereomicroscópio, com as coroas parafusadas a um único implante e posicionadas em uma matriz de silicone a fim de padronizar seu posicionamento. Os dados obtidos foram tabulados e submetidos à análise de variância, teste exato de Fisher e correlação linear de Pearson (p<0,05). Todas as mensurações de destorque foram inferiores ao torque de inserção, tanto antes quanto após a ciclagem...
Implant-supported prostheses are prone to several types of fail, and the retaining screw loosening is the most frequent complication, due to the loss of its initial preload. Loss of preload may be caused by different factors such as the incidence of excessive occlusal loading, different types of implant/prosthesis connections systems and vertical misfit between crown and implant. Thus, the aim of this study was to evaluate the preload maintenance of titanium retaining screws and to measure the vertical misfit of implant-supported screwed crowns, before and after mechanical cycling. For this purpose, three types of implant/abutment systems were embedded in polyester resin: internal hybrid connection implants and Estheticone abutments (Group ICE); external connection implants with Estheticone abutments (Group ECE); and external connection implants with UCLA abutments (Group ECU). For each group, 10 metallic crowns were cast in CoCrMo alloy for the final compositions of the specimens. Retaining screws received insertion torque of 20 N.cm in groups ICE and ECE and 30N.cm in group ECU, and, after three minutes, the initial detorque was measured through an analogical torquemeter. After this initial evaluation, crowns were retightened and submitted to cyclic loading test, with an oblique loading (30°) of 130N ± 10N, at 2Hz of frequency, totalizing 1x106 cycles. After cycling, final detorque was measured. Moreover, before and after mechanical cycling, the vertical misfit of the crowns was measured through estereomicroscopy, with the crowns screwed to a single implant and positioned into a silicone matrix. The data obtained were tabulated and submitted to variance analysis, Fishers exact test and Pearsons linear correlation (p<0,05). All detorque values were lower that the insertion torque, both before and after mechanical cycling. When groups were compared, there was no statistically significant difference before mechanical cycling. When groups were compared after...