الملخص
Abstract: Sulfur mustard is one of the chemical warfare agent. It rapidly reacts with the cutaneous tissues and other tissues, leading to various devastating long-term effects on human health. Mustard-exposed veterans suffer from its chronic skin problems, including itching, burning sensation, and eczema. We aimed to evaluate the protective effects of Myrtus communis L. (myrtle) on chronic skin lesions and quality of life of sulfur mustard-exposed veterans. In this randomized, double-blind clinical trial, 60 sulfur mustard-exposed patients were evaluated. Thirty patients received myrtle essence 5% cream (case group) and 30 patients received Eucerin cream (placebo group) twice in a day for one month. Then, We assessed the chronic skin problems and itching-related parameters (such as the itching time, severity, distribution, frequency, and calculated itching score), duration of sleep, number of waking up at night, and quality of life in the both groups. Our analysis of data revealed that application of myrtle cream effectively decreased skin problems including; itching and burning sensation. Additionally, myrtle markedly decreased skin lesion symptoms such as excoriation in the case group as compared with before treatment. Noticeably, myrtle cream significantly improved quality of life of the patients in the case group. The present study provides more in-depth information regarding the protective role of myrtle on the sulfur mustard-induces skin complication. Also, myrtle effectively improved quality of life of the sulfur mustard-exposed veterans.
الموضوعات
Humans , Middle Aged , Skin Diseases/chemically induced , Plant Extracts/therapeutic use , Chemical Warfare Agents/toxicity , Myrtus communis/therapeutic use , Phytotherapy , Mustard Gas/toxicity , Pruritus/chemically induced , Quality of Life , Veterans , Indicators of Quality of Life , Eczema/chemically induced , War Exposure/adverse effects , Iranالملخص
We report a case of a 42 year-old female, who came to a leishmaniasis reference center in Rio de Janeiro, Brazil, presenting a cutaneous leishmaniasis lesion in the right forearm. Treatment with low-dose intramuscular meglumine antimoniate (MA) (5 mg Sb5+/kg/day) was initiated, with improvement after 28 days, although with the development of generalized eczema. After 87 days, the lesion worsened. Patient refused treatment with amphotericin B. MA was then infiltrated in the lesion, in two sessions, resulting in local eczema, with bullae formation; however, twenty days after, both the ulcer and eczema receded. Intralesional administration of MA should be used carefully when previous cutaneous hypersensitivity is detected.
Relatamos caso de paciente de 42 anos atendida em centro de referência em leishmanioses no Rio de Janeiro, Brasil, apresentando lesão de leishmaniose cutânea no antebraço direito. Iniciado tratamento com baixa dose de antimoniato de meglumina (AM) intramuscular (5 mg Sb5+/kg/dia), houve melhora após 28 dias, porém com desenvolvimento de eczema generalizado. Após 87 dias, notou-se piora da lesão. A paciente recusou o tratamento com anfotericina B. Infiltrou-se AM na lesão em duas sessões, resultando em eczema local com bolhas. Entretanto, 20 dias depois, tanto a úlcera quanto o eczema regrediram. A administração intralesional do AM deve ser utilizada com cautela em pacientes com hipersensibilidade cutânea a este fármaco.
الموضوعات
Adult , Female , Humans , Antiprotozoal Agents/adverse effects , Drug Eruptions/drug therapy , Eczema/chemically induced , Leishmaniasis, Cutaneous/drug therapy , Meglumine/adverse effects , Organometallic Compounds/adverse effects , Antiprotozoal Agents/administration & dosage , Eczema/drug therapy , Injections, Intralesional , Injections, Intramuscular , Meglumine/administration & dosage , Organometallic Compounds/administration & dosageالملخص
Vários tipos de complicaçöes podem ocorrer com tatuagem. O autor relata um caso de reaçäo por sensibilizaçäo ao "Cinnabar" (pigmento vermelho) em tatuagem realizada na regiäo deltóidea. Esta reaçäo foi do tipo eczematosa. Ocorreu o clareamento progressivo do pigmento vermelho, seguido da completa reduçäo do processo eczematoso