الملخص
El eritema nodoso (EN) es la forma de paniculitis más común. Este trastorno representa una reacción de hipersensibilidad frente a diferentes antígenos, así como múltiples enfermedades sistémicas y fármacos, aunque en la mayoría de casos se desconoce la causa. Nuevos fármacos se añaden a la lista de involucrados en la etiopatogenia del eritema nodoso conforme van pasando los años, siendo uno de ellos los anticonceptivos hormonales orales combinados. El objetivo de este trabajo es proponer una relación entre los estrógenos de cualquier método anticonceptivo como puede ser el anillo vaginal combinado y la aparición del eritema nodoso.
Erythema nodosum (EN) is the most common form of panniculitis. This disorder represents a hypersensitivity reaction in front of different antigens, as well as multiple systemic diseases and drugs, although in most cases the cause is unknown. New drugs are added to the list of those involved in the etiopathogenesis of erythema nodosum as the years go by, one of them being combined oral hormonal contraceptives. The objective of this study is to propose a relationship between estrogens from any contraceptive method such as the combined vaginal ring and the appearance of erythema nodosum.
الموضوعات
Humans , Female , Young Adult , Contraceptive Devices, Female/adverse effects , Erythema Nodosum/chemically induced , Contraceptive Agents, Hormonal/adverse effects , Panniculitis/chemically induced , Drug Therapy, Combinationالملخص
La lepra es una infección crónica, granulomatosa, producida por Mycobacterium leprae, que afecta piel y nervios periféricos. Se describen dos tipos de reacciones leprosas: tipo I y tipo II, las que corresponden a cuadros agudos que exacerban la enfermedad. Estas leproreacciones pueden ocurrir antes, durante o después del tratamiento. Se presenta el caso de un paciente masculino que acude a consultar con lesiones cutáneas y resultado de biopsia de piel con diagnóstico de lepra. Se inicia tratamiento multidroga OMS-MB1. Posteriormente presenta una leproreacción tipo I, por lo que se le realiza tratamiento con prednisona.
Leprosy is a chronic granulomatous infection of the skin and peripheral nervous system produced by Mycobacterium leprae. Two types of acute leprosy reactions have been described: type I and type II. These reactions can occur before, during or after treatment. We present the case of an adult male patient presenting with skin lesions and skin biopsy diagnostic for leprosy. A multidrug WHO-MB 1 treatment was initiated, after which he presents with type I lepra reaction requiring corticosteroids.
الموضوعات
Humans , Male , Middle Aged , Leprosy, Lepromatous/diagnosis , Leprosy, Lepromatous/drug therapy , Clofazimine/adverse effects , Drug Therapy, Combination/adverse effects , Erythema Nodosum/chemically induced , Rifampin/adverse effects , Biopsy , Dapsone/adverse effects , Leprosy, Multibacillary/pathology , Leprostatic Agents/adverse effectsالملخص
The uneventful response to chemotherapy in leprosy is marked by clinically disturbing episodes encountered in 20-30% of patients and these phenomena are called "reactions". Generally they are classified as reversal reaction (type-1) and erythema nodosum leprosum (type-2). The cutaneous menifestations are: (1) Type-2 reactions in LL, BL types constituting erythema nodosum leprosum, erythema multiforme, erythema necroticans, subcutaneous nodules, lepromatous exacerbation. (2) Type-1 reactions in borderline and tuberculoid leprosy. The other manifestations include: Acute neuritis, lymphadenitis, arthritis, oedema of the hands and feet, ocular lesions, etc. Sequelae of reactions are: Paralytic deformities, non-paralytic deformities, extensive scarring and renal damage. A simple guideline to identify the risk-prone cases has been narrated. Prednisolone in standard dosage schedule as recommended by WHO is now being widely used in control programmes.
الموضوعات
Arthritis/chemically induced , Cicatrix/chemically induced , Clofazimine/adverse effects , Dose-Response Relationship, Drug , Drug Therapy/adverse effects , Edema/chemically induced , Erythema/chemically induced , Erythema Nodosum/chemically induced , Foot/pathology , Glucocorticoids/adverse effects , Hand/pathology , Humans , Hypersensitivity/etiology , Immunosuppressive Agents/adverse effects , Leprosy/drug therapy , Lymphadenitis/chemically induced , Neuritis/chemically induced , Paralysis/chemically induced , Prednisolone/adverse effects , Skin/drug effects , Thalidomide/adverse effects , Treatment Outcomeالملخص
La isotretinoína es una droga efectiva para el tratamiento del acné. Su uso puede acompañarse de diversas reacciones adversas, tales como queilitis, xerodermia, epistaxis, prurito, trastornos oculares y cefalea. Presentamos un paciente de 17 años que desarrolló acné fulminans, eritema nodoso y complejos inmunes circulantes, diez días después de haber comenzado el tratamiento con isotretinoína. Se discuten los aspectos etiopatogénicos del acné fulminans
الموضوعات
Male , Humans , Adolescent , Acne Vulgaris/complications , Erythema Nodosum/chemically induced , Isotretinoin/adverse effects , Acne Vulgaris/diagnosis , Acne Vulgaris/drug therapy , Drug Hypersensitivity/therapy , Erythema Nodosum/etiology , Isotretinoin/pharmacology , Isotretinoin/immunologyالملخص
Foram estudadas quatro crianças com diagnóstico clínico e histopatológico de eritema nodoso. Como fatores citológicos: tuberculose pulmonar (um caso), infecçåo estreptocócica (um caso), Dipirona (um caso); em um caso nåo se detectou a etiologia. Destacam-se a ausência de publicaçöes em nosso meioe o interesse do eritema nodoso no diagnóstico de doenças gerais associadas