الملخص
Resumen El tumor desmoplásico de célula redonda y pequeña (TDCRP) es una patología neoplásica maligna agresiva y poco común. Afecta predominantemente a hombres entre la segunda y tercera década de la vida. Los pacientes que la padecen tienen un pronóstico pobre, con una supervivencia global a 5 años de hasta el 30%. Por lo general se presenta como una masa en la cavidad abdominal, frecuentemente multifocal. Para su tratamiento se recomienda un enfoque multimodal con cirugía, quimioterapia y radioterapia. Poco más de 20 casos de TDCRP a nivel testicular/paratesticular se han reportado en la literatura. A continuación, se presenta un caso ilustrativo en esta localización, se discute el caso y se realiza revisión de la literatura.
Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive and rare malignant neoplasm. It mainly affects young men in their twenties and thirties. Patients with it have a poor prognosis, with a 5-year survival rate of up to 30%. It generally presents as a mass in the abdominal cavity, often multifocal. A multimodal approach is recommended for its treatment, with surgery, chemotherapy, and radiotherapy. Just over 20 cases of testicular/paratesticular DSRCT have been reported in the literature. Below, we present an illustrative case in this location, we discuss the case and review the literature.
الموضوعات
Humans , Male , Adult , Retroperitoneal Neoplasms/diagnosis , Retroperitoneal Neoplasms/therapy , Desmoplastic Small Round Cell Tumor/diagnosis , Desmoplastic Small Round Cell Tumor/therapy , Genital Neoplasms, Male/diagnosis , Genital Neoplasms, Male/therapy , Testicular Neoplasms/diagnosis , Testicular Neoplasms/therapy , Gangliaالملخص
Background: Information is scarce about the presence of molecular alterations related to human papillomavirus (HPV) infection in squamous cell carcinomas of the genital skin and about the effect of this infection in the number of Langerhans cells present in these tumors. Aims: To determine the presence of HPV in genital skin squamous cell carcinomas and to see the relationship between HPV infection and changes in the expression of Ki-67 antigen (Ki-67), p53 protein (p53), retinoblastoma protein (pRb) and E-cadherin and to alterations in Langerhans cell density, if any. Methods: A descriptive, comparative, retrospective and cross-sectional study was performed with all the cases diagnosed as squamous cell carcinomas of the genital skin at the Dermatopathology Service from 2001 to 2011. The diagnosis was verified by histopathological examination. The presence of HPV was examined using chromogenic in situ hybridization, and protein expression was studied via immunohistochemical analysis. Results: The 34 cases studied were verified as squamous cell carcinomas and 44.1% were HPV positive. The degree of expression of pRb was 17.50% ±14.11% (mean ± SD) in HPV-positive cases and 29.74% ±20.38% in HPV-negative cases (P = 0.0236). The degree of expression of Ki-67 was 47.67% ±30.64% in HPV-positive cases and 29.87% ±15.95% in HPV-negative cases (P = 0.0273). Conclusion: HPV infection was related to lower pRb expression and higher Ki-67 expression in comparison with HPV negative samples. We could not find a relationship between HPV infection and the degree of expression of p53 and E-cadherin or with Langerhans cell density.
الموضوعات
Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/genetics , Cross-Sectional Studies , DNA Fingerprinting/methods , Female , Genital Neoplasms, Female/diagnosis , Genital Neoplasms, Female/genetics , Genital Neoplasms, Male/diagnosis , Genital Neoplasms, Male/genetics , Humans , Langerhans Cells/pathology , Male , Middle Aged , Papillomavirus Infections/diagnosis , Papillomavirus Infections/genetics , Retrospective Studies , Skin Neoplasms/diagnosis , Skin Neoplasms/genetics , Young Adultالموضوعات
Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/genetics , Cross-Sectional Studies , DNA Fingerprinting/methods , Female , Genital Neoplasms, Female/diagnosis , Genital Neoplasms, Female/genetics , Genital Neoplasms, Male/diagnosis , Genital Neoplasms, Male/genetics , Humans , Langerhans Cells/pathology , Male , Middle Aged , Papillomavirus Infections/diagnosis , Papillomavirus Infections/genetics , Retrospective Studies , Skin Neoplasms/diagnosis , Skin Neoplasms/genetics , Young Adultالملخص
Metastatic tumour of spermatic cords, epididymis and seminiferous duct from gastric carcinoma has been recently reported but rarely seen. A case of metastatic tumour from gastric carcinoma in a 50-year old man is herein reported. The initial diagnosis was thickening of both spermatic cords. Needle biopsy of the spermatic cord, testicle and epididymis was performed. Pathological findings showed a gastric signet ring cell carcinoma. Thus, double radical orchiectomy was performed and metastatic signet ring cell carcinoma of the spermatic cord and testis was diagnosed through histological examination and immunohistochemistry. Physicians should be aware that gastric carcinoma is one of the possibilities for metastasis to the seminal duct.
El tumor metastásico de los cordones espermáticos, el epidídimo y el conducto seminífero a partir de un carcinoma gástrico ha sido reportado recientemente, pero pocas veces visto. En este trabajo se reporta el caso de un tumor metastásico a partir de un carcinoma gástrico en un hombre de 50 año de edad. El diagnóstico inicial fue el engrosamiento de los dos cordones espermáticos. Se realizó una biopsia con aguja del cordón espermático, testículos y epidídimo. Los resultados patológicos mostraron un carcinoma de células en anillo de sello. Por consiguiente, se realizó una orquiectomía radical doble, y el carcinoma metastásico en anillo de sello del cordón espermático y el testículo, fue diagnosticado mediante examen histológico e inmunohistoquímico. Los médicos deben tener presente que el carcinoma gástrico es una de las posibilidades de metástasis en los conductos seminales.
الموضوعات
Humans , Middle Aged , Spermatic Cord/pathology , Stomach Neoplasms/pathology , Carcinoma/pathology , Genital Neoplasms, Male/secondary , Biopsy, Needle , Orchiectomy , Genital Neoplasms, Male/surgery , Genital Neoplasms, Male/diagnosisالملخص
Primary lymphomas of the spermatic cord are extremely rare. To date, only 15 cases have been reported in the international literature. Herein, we report a new case of a primary lymphoma of the spermatic cord. A 73-year-old patient presented at the Urology Department, complaining of bilateral painful masses at the inguino-scrotal region. A computed tomography scan revealed spermatic cord tumor. A right inguinal orchidectomy was performed in order to establish a definitive diagnosis. Macroscopically, the tumor was restricted to the spermatic cord area, leaving unaffected the testis and the epididymis. The histopathological and immune-histological evaluation has indicated a diffuse large B-cell lymphoma. Postoperatively, the patient was investigated thoroughly but no further signs of the disease were found.
الموضوعات
Aged , CD79 Antigens/analysis , Genital Neoplasms, Male/diagnosis , Genital Neoplasms, Male/pathology , Histocytochemistry , Humans , Immunohistochemistry , Lymphoma/diagnosis , Lymphoma/pathology , Male , Microscopy , Radiography, Abdominal , Spermatic Cord/pathology , Tomography, X-Ray Computedالملخص
Seminal vesicle tumor is a rare disease with unclear origin. Generally, it is presented as a pelvic mass that can be detected by sonography and digital rectal exam. The authors report a 25-year-old patient with a pelvic mass which the magnetic resonance and surgical specimen reveal a seminal vesicle tumor. Immunohistochemical findings favored a primitive neuroectodermal tumor of the seminal vesicle. Herein, the treatment, histological and histochemical findings of this entity are discussed.
الموضوعات
Humans , Male , Adult , Genital Neoplasms, Male/diagnosis , Neuroectodermal Tumors, Primitive, Peripheral/diagnosis , Seminal Vesicles/pathology , Antineoplastic Combined Chemotherapy Protocols , Chemotherapy, Adjuvant , Follow-Up Studies , Genital Neoplasms, Male/drug therapy , Genital Neoplasms, Male/surgery , Immunohistochemistry , Magnetic Resonance Imaging , Neuroectodermal Tumors, Primitive, Peripheral/drug therapy , Neuroectodermal Tumors, Primitive, Peripheral/surgery , Seminal Vesicles/surgery , Treatment Outcomeالملخص
Adenomatoid tumours are neoplasms of male and female genital tract with the epididymis being the most common site. They also occur in uterus, fallopian tube, and ovary. These benign tumours are asymptomatic or cause mild symptoms and a palpable mass. Fine needle aspiration of these tumours is very useful to differentiate malignant from benign lesions and helps to avoid unnecessary aggressive surgical procedures. FNAC of these benign epididymal tumours is diagnostic, rapid, reliable, conclusive and cost effective. We are reporting a case of adenomatoid tumour of epididymis in a 41 year old male patient, diagnosed by FNAC and confirmed by histopathology.
الموضوعات
Adenomatoid Tumor/diagnosis , Adult , Biopsy, Fine-Needle , Diagnosis, Differential , Epididymis , Female , Genital Neoplasms, Male/diagnosis , Humans , Maleالموضوعات
Angiolipoma/diagnosis , Child, Preschool , Genital Neoplasms, Male/diagnosis , Humans , Male , Scrotumالملخص
Malignant fibrous histiocytoma (MFH) of the spermatic cord is rare. However, owing to its location it is diagnosed early and has a better prognosis. A case of MFH of the spermatic cord is reported in a 50-year-old male along with review of the literature, discussing the recommended management and prognosis of this condition and emphasising upon its clinical recognition since the prognosis and management are different from the MFH, in general.
الموضوعات
Genital Neoplasms, Male/diagnosis , Histiocytoma, Benign Fibrous/diagnosis , Humans , Male , Middle Aged , Spermatic Cord/pathologyالموضوعات
Aged , Aged, 80 and over , Genital Neoplasms, Male/diagnosis , Humans , Liposarcoma, Myxoid/diagnosis , Male , Spermatic Cordالملخص
Spindle cell haemangioendothelioma (SCH) is a low grade, slowly progressive angiosarcoma of multifocal nature with local recurrences being common. It is histologically marked by cavernous blood spaces and a spindle cell stroma. Its importance lies in recognising its relatively benign nature and differentiating it from the ominous Kaposi's sarcoma. Our case reiterates the characteristics of this recently described disease, probably the first reported from India.
الموضوعات
Abdominal Muscles , Aged , Diagnosis, Differential , Genital Neoplasms, Male/diagnosis , Hemangioendothelioma/diagnosis , Humans , Male , Neoplasms, Multiple Primary/diagnosis , Sarcoma, Kaposi/diagnosis , Scrotum , Thighالملخص
Os tumores de testiculo representam uma forma rara de neoplasia no sexo masculino. No periodo de 12 anos, foram atendidos 234 individuos portadores de tumor germinativo do testiculo, e destes, 173 foram seguidos no periodo pos-operatorio. Do total analisado, 137 eram seminomas que responderam satisfatoriamente ao tratamento e com sobrevida de 96 por cento em 3 anos, e 38 tumores nao-seminomatosos, cuja taxa de sobrevida foi de 84 por cento , no mesmo periodo. Dois pacientes apresentaram tumores em ambos os testiculos, de forma assincronica. O acompanhamento pos-operatorio medio foi de 36 meses